Purpose: While there are no clear indications of whether central lymph node dissection is necessary in patients with T1-T2, non-invasive, clinically uninvolved neck nodes papillary thyroid carcinoma (PTC), this study seeks to develop and validate models for predicting the risk metastasis (CLNM) these based on machine learning algorithms. Methods: This a retrospective comprising 1,271 T1-T2 stage, negative (cN0) PTC who underwent surgery at Department Endocrine Breast Surgery The First...

Abstract Purpose To comprehensively investigate the implications of lymph node dissection (LND) and prognostic impact number (LN) metastases on survival in intrahepatic cholangiocarcinoma (ICC) using a large‐scale study. Methods Patients who underwent surgical resection for ICC between 2004 2018 were identified from Surveillance, Epidemiology, End Results (SEER) registries. The Kaplan–Meier log‐rank tests used to compare cancer‐specific (CSS) overall (OS) different groups. Propensity score...

Mutations of BRAFV600E and TERT promoters are associated with thyroid cancer development. This study further investigated association these mutations clinicopathological characteristics from patients papillary carcinoma (PTC).Tumor tissues 342 PTC were obtained for DNA extraction polymerase chain reaction amplification to detect the mutation using amplification-refractory system-polymerase reaction. promoter assessed Sanger sequencing. The gene was then statistically analyzed.Two hundred...

Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central (CLN) dissection or lateral (LLN) dissections to prevent still controversial. This study aimed retrospectively investigate the risk factors LLN in clinical node-negative (cN0) PTC patients. We studied 783 patients who underwent total thyroidectomy plus CLN and dissection. The rates metastases were 68.2 47.4%, respectively. Large tumor size (> 20 mm) had a fourfold...

Increasing evidence indicates that angiogenesis is crucial in the development and progression of gastric cancer (GC). This study aimed to develop a prognostic relevant angiogenesis-related gene (ARG) signature nomogram. The expression profile 36 ARGs clinical information 372 GC patients were extracted from Cancer Genome Atlas (TCGA). Consensus clustering was applied divide into clusters 1 2. Least absolute shrinkage selection operator (LASSO) Cox regression analyses used identify survival...

Abstract Ferroptosis is a new form of regulated cell death (RCD), and its emergence has provided approach to the progression drug resistance breast cancer (BRCA). However, there still great gap in study ferroptosis-related genes BRCA, especially luminal-type BRCA patients. We downloaded mRNA expression profiles corresponding clinical data patients from Molecular Taxonomy Breast Cancer International Consortium (METABRIC) The Genome Atlas (TCGA) databases. Then, we built prognostic multigene...

<title>Abstract</title> <bold>Introduction</bold>: Early-stage breast cancer treated with adjuvant radiotherapy two different techniques, Tomotherapy (TOMO) and intensity-modulated radiation therapy (IMRT) their acute adverse events in terms of skin toxicity, localized edema, sore throat, tracheal mucositis, nausea, mucositis oral, esophagitis pneumonitis outcomes are compared. <bold>Material/methods</bold>: A retrospective cohort study was conducted on comparing IMRT TOMO early-stage...

To identify a prognostic significant gene signature for predicting colorectal cancer (CRC) recurrence.Traditional risk assessment in stage II/III CRC patients remains controversial. Epithelial-mesenchymal transition is thought to be closely related the malignant progression of tumors. Thus, it promising establish model based on epithelial-mesenchymal transition-related (ERG) signature.We retrospectively analyzed transcriptome profiles and clinical information 1780 from 15 public datasets....

A combination of pegylated interferon-alpha (peg-IFN-α) and nucleos(t)ides analogue (NA) therapy can effectively reduce hepatitis B surface antigen (HBsAg), especially in NA-experienced chronic (CHB) patients. However, the immune mechanism this is unclear. Forty CHB patients were enrolled into study. The frequencies peripheral blood natural killer (NK) cells, dendritic cells (DCs), CD4+ T CD8+ helper (Th) regulatory (Treg ), follicular (Tfh) evaluated by flow cytometry. Seven 40 converted to...

Breast cancer patients show significant heterogeneity in overall survival. Current assessment models are insufficient to accurately predict patient prognosis, and for predicting treatment response lacking. We evaluated the relationship between various immune cells breast confirmed association infiltration progression. Different bioinformatics statistical approaches were combined construct a robust infiltration-related gene signature prognosis responses immunotherapy chemotherapy. Our...

Bladder cancer (BCa) is a common urothelial malignancy. The Cancer Genome Atlas (TCGA) database allows for an opportunity to analyze the relationship between gene expression and clinical outcomes in bladder patients. This study aimed at identifying prognosis-related genes microenvironment.Immune scores stromal were calculated by applying ESTIMATE algorithm. We divided patients into high low groups based on their immune/stromal scores. Then, differentially expressed (DEGs) identified TCGA...

Background: As is known, identifying risk factors precisely for lymph node metastasis (LNM) plays a vital role in initial treatment papillary thyroid carcinoma (PTC). Nonetheless, whether Delphian (DLN) has value predicting LNM remains an open question. This study covered sample of 1,575 patients, which the largest group so far, aiming to assess predictive validity DLN PTC. Methods: retrospective cohort was conducted with eligible PTC patients who underwent operation between July 2013 and...

BACKGROUND:Stromal and immune cells play essential roles in the development of breast cancer (BC). This study was conducted to identify prognosis-related genes from tumor microenvironment. MATERIAL AND METHODS:The gene expression profiles 622 BC samples were downloaded TCGA (The Cancer Genome Atlas) database. Stromal scores calculated by using ESTIMATE (Estimation STromal Immune MAlignant Tumours Expression data) algorithm. Then, differentially expressed (DEGs) between high score group low...

Sarcomas are a heterogeneous group of rare mesenchymal tumors. The migration immune cells into these tumors and the prognostic impact tumor-specific factors determining their interaction with remain poorly understood. current risk stratification system is insufficient to provide precise survival prediction treatment response. Thus, valid models needed guide treatment. This study analyzed gene expression outcome 980 sarcoma patients from seven public datasets. abundance response immunotherapy...

The incidence of papillary thyroid carcinoma (PTC) is higher in females than males, but it remains unclear whether gender associated with the aggressiveness this disease. We aimed to clarify influence on risk developing lymph node metastasis (LNM) and prognosis PTC patients. Study Design. Retrospective cohort study. Setting. Academic tertiary care center. Clinical data patients who were admitted Department Endocrine Breast Surgery, First Affiliated Hospital Chongqing Medical University,...

We aimed to establish a prediction model based on preoperative clinicopathologic features and intraoperative frozen section examination for precise of metastatic involvement lymph nodes posterior the right recurrent laryngeal nerve (LN-prRLN) in patients with papillary thyroid carcinoma (PTC).Clinicopathologic data pertaining PTC who underwent initial surgery between July 2015 December 2017 were collected from electronic medical records. Multivariate logistic regression analysis was...

Abstract Background Colorectal cancer (CRC) is the third most common malignancy worldwide, but key driver to distant metastases still unknown. This study aimed elucidate link between immunosurveillance and organotropism of in CRC by evaluating different gene signatures pathways. Material methods patients undergoing surgery at Department General, Visceral Transplantation Surgery Ludwig-Maximilian University Hospital Munich (Munich, Germany) were screened categorized into M0 (no metastases),...

BACKGROUND:The anti-inflammatory drug sulfasalazine (SAS) has been confirmed to inhibit the growth of triple-negative breast cancer (TNBC), but mechanism is not clear. The aim this study was use network pharmacology find relevant pathways SAS in TNBC patients. MATERIAL AND METHODS:Through screening GeneCards, CTD, and ParmMapper databases, potential genes related were identified. In addition, gene ontology Kyoto Encyclopedia Genes Genomes analyses performed using R programming language....

Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by spread thus it imperative to understand its key drivers develop biomarkers for risk stratification, follow-up protocols and personalized therapy. Thus, this study aimed identify genes route CRC.CRC patients resected at our clinic from 2005 2014 a minimum 5-year were included analysis grouped into CRC hepatic (HEP), peritoneal (PER) or without distant metastases...