A5068674125- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Breast Cancer Therapies
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Tumors and Oncological Cases
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Pediatric health and respiratory diseases
Ludwig-Maximilians-Universität München
2017-2025
LMU Klinikum
2016-2025
German Cancer Research Center
2017-2025
Heidelberg University
2017-2025
University Hospital Heidelberg
2025
Deutschen Konsortium für Translationale Krebsforschung
2018-2024
Institute of Clinical Cancer Research
2024
German Marine Research Consortium
2021
Maastricht University
2021
Taipei Institute of Pathology
2021
PURPOSE The FIRE-4 study randomly assigned patients with first-line RAS wild-type ( wt) metastatic colorectal cancer to either flourouracil (FU), folinic acid, and irinotecan (FOLFIRI) plus cetuximab until progression or intolerable toxicity (standard arm) FOLFIRI followed by a switch maintenance treatment using FU bevacizumab (experimental arm). Here, we investigate the relevance of liquid biopsy (LB) BRAF testing compared tissue-based analyses. PATIENTS AND METHODS LBs were taken at...
Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated their ability to detect eight cell lines and 18 FFPE tissue samples carrying a variety known fusions. Four RNA-based one DNA-based assay compared; two hybrid capture-based, TruSight Tumor 170 Assay (Illumina) SureSelect XT HS Custom Panel (Agilent), three...
NTRK fusions involving three neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2, and NTRK3 a variety of fusion partners were identified as oncogenic drivers across many cancer types. Drugs that target the chimeric protein product require identification underlying gene fusion. This advocates diagnostic use molecular assays ranging from fluorescence in situ hybridization (FISH) reverse transcription polymerase chain reaction (RT-PCR)/Sanger approaches to targeted next-generation...
The necrotic core partly formed by ineffective efferocytosis increases the risk of an atherosclerotic plaque rupture. Microribonucleic acids contribute to formation regulating and macrophage apoptosis. Atherosclerotic rupture occurs at increased frequency in early morning, indicating diurnal changes vulnerability. Although circadian rhythms play a role atherosclerosis, molecular clock output pathways that control composition susceptibility are unclear.Circadian gene expression, size,...
In pancreatic cancer, systemic treatment options in addition to chemotherapy remain scarce, and so far only a small proportion of patients benefit from targeted therapies.The with cancer discussed the CCCMunichLMU Molecular Tumor Board were reviewed gain better real-world understanding challenges chances precision oncology this hard-to-treat cancer.Patients who received comprehensive genomic profiling interdisciplinary between May 2017 July 2022 included. These patients' medical charts,...
Advances in molecular tumor diagnostics have transformed cancer care. However, it remains unclear whether precision oncology has the same impact and transformative nature across all malignancies. We conducted a retrospective analysis of patients with human papillomavirus (HPV)-related gynecologic malignancies who underwent comprehensive profiling subsequent discussion at interdisciplinary Molecular Tumor Board (MTB) University Hospital, LMU Munich, between 11/2017 06/2022. identified total...
Abstract Purpose: Patients with estrogen receptor– and/or progesterone receptor–positive, early breast cancer benefit from hormonal treatment, yet high global death burdens due to prevalence and long-term recurrence risk call for biomarkers guide additional treatment approaches. Experimental Design: From a prospective, observational study of postmenopausal patients treated tamoxifen or aromatase inhibitors, gene expression analyses 612 tumors was performed using the NanoString Breast Cancer...
Gene fusions involving the three neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2, or NTRK3 were identified as oncogenic drivers in many cancer types. Two small molecule inhibitors have been tested clinical trials recently and require detection of a NTRK fusion gene prior to therapeutic application. Fluorescence situ hybridization (FISH) targeted next-generation sequencing (tNGS) assays are commonly used for diagnostic profiling fusions. In presented study we applied an external...
With the rising importance of precision oncology in biliary tract cancer (BTC), aim this retrospective single-center analysis was to describe clinical and molecular characteristics patients with BTC who underwent comprehensive genomic profiling (CGP) were discussed CCCMunichLMU tumor board (MTB).In observational study, we included intrahepatic cholangiocarcinoma (iCCA), extrahepatic CCA (eCCA), gallbladder (GB), had been institutional MTB from May 29, 2017, July 25, 2022. Patients followed...
Abstract Although initially assumed to be similar, immune checkpoint inhibitor (ICI)-induced autoimmunity can differ from spontaneous autoimmune disease regarding clinical presentation, pathogenesis and therapy. Despite limited pathogenetic understanding, ICI-induced colitis (irColitis), a common adverse event during ICI therapy, is treated analogously its counterpart, ulcerative (UC). Thus, there tremendous need characterize immunophenotypes in both forms of colonic inflammation ultimately...
Background: In the era of precision medicine, cancer treatment is increasingly tailored according to tumor-specific genomic alterations. The analysis tumor-derived circulating nucleic acids in cerebrospinal fluid (CSF) by next generation sequencing (NGS) may facilitate medicine field CNS cancer. We therefore evaluated whether NGS from CSF neuro-oncologic patients reliably detects alterations and this help guide management with clinical practice. Patient methods: samples 27 various primary...
While childhood asthma prevalence is rising in Westernized countries, farm children are protected. The mitogen-activated protein kinase (MAPK) pathway with its negative regulator dual-specificity phosphatase-1 (DUSP1) presumably associated development.We aimed to investigate the role of MAPK signaling and environment-mediated protection, including a representative selection 232 out 1062 from two cross-sectional cohorts one birth cohort study.Peripheral blood mononuclear cells (PBMC)...
Brain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung bone no biomarkers exist to identify patients at risk. This study aimed gene expression signature associated BM.
Abstract The aim of the study was to investigate predictive impact extracranial metastatic patterns on course disease and survival in patients with colorectal cancer (CRC) brain metastasis (BM). A total 228 (134 male [59%], 94 female [41%]) histologically proven CRC BM were classified into different groups according patterns. Time intervals events times from initial diagnosis, intracranial analyzed. Extracranial organs mostly affected liver (102 [44.7%]) lung (96 [42.1%]). Liver metastases...
Head and neck squamous cell carcinoma remains a substantial burden to global health. Despite evolving therapies, 5-year survival is <50% unlike in other cancers, reliable molecular biomarkers guide treatment do not exist.We performed targeted panel next-generation sequencing analyse somatic variants from primary recurrent tumour tissue, corresponding resection margins cell-free DNA intra-operatively collected plasma samples eight patients with human papillomavirus-negative head carcinoma....
Epithelial-mesenchymal transition (EMT), angiogenesis, cell adhesion and extracellular matrix (ECM) interaction are essential for colorectal cancer (CRC) metastasis. Low grade mucinous neoplasia of the appendix (LAMN) its advanced state low pseudomyxoma peritonei (lgPMP) show local aggressiveness with very limited metastatic potential as opposed to CRC. To better understand underlying processes that foster or impede spread, we compared LAMN, lgPMP, CRC respect their molecular profile...
Lung cancer is a paradigm for genetically driven tumor. A variety of drugs were developed targeting specific biomarkers requiring testing tumor genetic alterations in relevant biomarkers. Different next-generation sequencing technologies are available library generation: 1) anchored multiplex-, 2) amplicon based- and 3) hybrid capture-based-PCR. Anchored multiplex PCR-based was investigated routine molecular within the national Network Genomic Medicine Cancer (nNGM). Four centers applied...