A5026117937- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Cancer therapeutics and mechanisms
- Cellular transport and secretion
- Congenital heart defects research
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Zebrafish Biomedical Research Applications
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Radiopharmaceutical Chemistry and Applications
- Cancer and Skin Lesions
- Meningioma and schwannoma management
- Genetics and Neurodevelopmental Disorders
- Chromosomal and Genetic Variations
- Microtubule and mitosis dynamics
- Mosquito-borne diseases and control
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
Memorial Sloan Kettering Cancer Center
2016-2025
Kettering University
2017-2025
Cornell University
2015-2020
Tri-Institutional PhD Program in Chemical Biology
2017-2020
Massachusetts General Hospital
2009-2017
Neurological Surgery
2015-2017
The University of Texas Southwestern Medical Center
2017
New York Stem Cell Foundation
2017
NewYork–Presbyterian Hospital
2015
First Hospital of Jilin University
2013
Microtubules are essential components of axon guidance machinery. Among β-tubulin mutations, only those in TUBB3 have been shown to cause primary errors guidance. All identified mutations TUBB2B result polymicrogyria, but it remains unclear whether can dysinnervation as a phenotype. We novel inherited heterozygous missense mutation that results an E421K amino acid substitution family who segregates congenital fibrosis the extraocular muscles (CFEOM) with polymicrogyria. Diffusion tensor...
Abstract BACKGROUND Maximizing extent of resection (EOR) improves outcomes in adults with World Health Organization (WHO) grade II low-grade gliomas (LGG). However, recent studies demonstrate that LGGs bearing a mutation the isocitrate dehydrogenase 1 (IDH1) gene are distinct molecular and clinical entity. It remains unclear whether maximizing EOR confers an equivalent benefit IDH mutated (mtIDH) wild-type (wtIDH) LGGs. OBJECTIVE To assess impact on malignant progression-free survival (MPFS)...
Molecular controls over the development of exceptional neuronal subtype diversity cerebral cortex are now beginning to be identified. The initial fate decision early in life a neuron, and malleability this when balance key postmitotic signals is modified, reveals not only that neuron deterministically set on general developmental path at its birth, but also program must precisely executed during differentiation. Here, we show callosal projection neurons (CPN) subcerebral (subcerebral PN)...
The mammalian neocortex is parcellated into anatomically and functionally distinct areas. establishment of area-specific neuronal diversity circuit connectivity enables neocortical regions to control diverse specialized functional outputs, yet underlying molecular controls remain largely unknown. Here, we identify a central role for the transcriptional regulator Lim-only 4 (Lmo4) in establishing subtypes within rostral mouse motor cortex, where projection neurons have particularly...
Survival duration and prognostic factors in adult high-grade glioma have been comprehensively analyzed, but less is known about contributing to overall survival (OS) progression-free (PFS) pediatric patients.To identify these the population.We retrospectively reviewed institutional databases evaluating all patients ≤21 years with treated between 1988 2010. Kaplan-Meier curves log-rank statistics were used compare groups univariately. Multivariate analyses completed using Cox proportional...
OBJECTIVE The authors of this study aimed to identify the incidence and risk factors for preoperative deep venous thrombosis (DVT) in patients undergoing surgical treatment spinal metastases. METHODS Univariate analysis patient age, sex, ethnicity, laboratory values, comorbidities, ambulatory status, histopathological classification, level, details was performed. Factors significantly associated with DVT univariately were entered into a multivariate logistic regression model. RESULTS...
Abstract Background Contemporary outcomes and relapse patterns in primary CNS lymphoma (PCNSL) are lacking. We analyzed factors associated with a large cohort extensive follow-up. Methods T1-post-contrast-enhancing disease was characterized immunocompetent PCNSL (diffuse B-cell) patients from 1983 to 2020. Patients were stratified by response induction consolidation (complete/unconfirmed [CR/CRu], partial, stable, progression [POD]). Refractory POD during (or ≤3 months of) induction. Initial...
This cohort study examines the risk of radiation-associated sarcoma in patients with breast cancer harboring germline TP53 variants.
Abstract Despite the litany of pathogenic variants linked to neurodevelopmental disorders (NDD) including autism (ASD) and intellectual disability 1,2 , our understanding underlying mechanisms caused by risk genes remain unclear. Here, we leveraged a human pluripotent stem cell model uncover consequences mutations in ZMYND11 newly implicated gene 3,4 . ZMYND11, known for its tumor suppressor function, encodes histone-reader that recognizes sites transcriptional elongation acts as...
Spine and nonspine skeletal metastases occur in more than 80% of patients with prostate cancer.To examine the characteristics patient population undergoing surgery for treatment cancer metastatic to spine.A retrospective chart review was performed on all treated at our institution from June 1993 August 2014 surgical management spine disease cancer.During study period, 139 157 lesions underwent disease. Decompression high-grade epidural spinal cord compression required 126 143 lesions....
Patel, Toral R MD; Bander, Evan D Venn, Rachael A; Avila, Tiffany L Powell Cederquist, Gustav Y; Schaefer, Peter M; Puchi, Luis Akhmerov, Akbarshakh; Ogoupilvie, Shahiba MPH; Reiner, Anne; Moussazadeh, Nelson Tabar, Viviane S MD