A5043958511- Pregnancy and Medication Impact
- Infant Nutrition and Health
- Gut microbiota and health
- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Pediatric Urology and Nephrology Studies
- Pregnancy and preeclampsia studies
- Urinary Tract Infections Management
- Tuberculosis Research and Epidemiology
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Cardiac Imaging and Diagnostics
- Heavy Metal Exposure and Toxicity
- Fecal contamination and water quality
- Digestive system and related health
- Infant Health and Development
- Obesity and Health Practices
- Connective tissue disorders research
- Electrolyte and hormonal disorders
- Health Sciences Research and Education
- Gun Ownership and Violence Research
- Preterm Birth and Chorioamnionitis
Pennsylvania State University
2021-2024
Icahn School of Medicine at Mount Sinai
2016-2023
Hershey (United States)
2022
Penn State Milton S. Hershey Medical Center
2022
Mount Sinai Hospital
2019
Pediatrics and Genetics
2016
Background and aims Prenatal early life bacterial colonisation is thought to play a major role in shaping the immune system. Furthermore, accumulating evidence links exposures risk of developing IBD later life. We aimed assess effect maternal on composition microbiome during pregnancy offspring’s microbiome. Methods prospectively examined diversity taxonomy pregnant women with without their babies at multiple time points. evaluated diagnosis, mode delivery, antibiotic use feeding behaviour...
Crohn's disease (CD), a type of inflammatory bowel (IBD), is chronic condition the gastrointestinal tract that caused by loss mucosal tolerance towards commensal bacteria resulting in responses. It has long been postulated gut microbiota, complex and dynamic population microorganisms, plays key role pathogenesis IBD. Maternal diagnosis IBD identified as greatest risk factor for offspring increasing odds developing >4.5-fold. Moreover, babies born to mothers with have demonstrated reduced...
Herein we analysed the influence of early life factors, including breast milk composition, on development intestinal microbiota infants born to mothers with and without IBD.
Monitoring IBD activity during pregnancy is challenging because clinical and laboratory markers may be altered due to the physiological adaptation that occurs, endoscopy use limited. Fecal Lactoferrin (FL) a non-invasive biomarker of gut inflammation used for diagnostics management IBD; however, little known about its in pregnant women. Herein, we investigated FL concentrations control women, participating MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through Microbiome)...
There is an increased risk of IBD in children born to mothers with IBD. We previously showed that babies had evidence gut microbiota dysbiosis at birth persisted up 3 months life. Herein, we investigated FC concentrations as a biomarker inflammation or without during their first year life, participating the MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through Microbiome) study. 243 infant stool samples obtained 2 weeks (2w), (2m) and 1 (1y) from 122 (33 IBD) were analysed...
Background: New evidence suggests that the GI tract of newborns starts to become colonised in utero.The source these microbiota is continued interest as initial colonisation bacteria believed play a crucial role development immune system.Yet, no data exist on effect IBD gut pregnant women and they pass their newborns.Methods: The MECONIUM Study prospective study aimed investigate pregnancy baby's microbiome.Clinical data, stool, saliva samples were collected from with without during...
Background: Human studies have demonstrated changes in the diversity and abundance of microbiome during pregnancy coinciding with maternal immune status. Furthermore, accumulating evidence suggests that health may influence newborn's development. These balancing acts be even more complicated pregnant women IBD, who exhibit a variety immunological gut microbiota alterations. Yet, no data exist on effect IBD pregnancy, its role infant composition. Methods: The “Exploring MEChanisms Of disease...
of ECCO -European Crohn's and Colitis Organisation S087Conclusions: Tollip promotes colitis-associated carcinogenesis despite being protective against colitis.Our data suggest that favours leukocytes infiltration in the colonic mucosa, potentially via regulation inflammatory migration
Environmental factors are thought to play a major role in the pathogenesis of inflammatory bowel disease (IBD). Importantly, increasing epidemiological evidence suggests that exposures occurring during early life may be determinant development. However, studying this window susceptibility is challenging, and very little has been elucidated about environmental preceding onset. Teeth develop an incremental manner, storing information on compounds such as metals organics we age. The study...
Abstract Background Breastmilk (BM) is a complex fluid that contributes to shaping the immune system of offspring. BM composition depends on stage lactation, maternal health status and diet, environment, genetics. Limited data exists from women with IBD its potential impact newborn’s microbiome composition. Methods The MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through Microbiome) study prospective cohort including pregnant IBD, healthy control (HC), their samples were...
Abstract Background IBD often affects women during their reproductive years; however, the effect of pregnancy on disease course remains poorly understood. We aimed to assess intestinal inflammation in patients compared with controls as measured by faecal calprotectin (FC). also investigated whether maternal diagnosis was associated altered FC offspring and if there were particular bacterial taxa that correlated levels. Methods Pregnant or without infants prospectively enrolled MECONIUM study...
IBD patients experience greater stress, anxiety and depression which impair quality of life increase disease burden. It is not known whether women with have more stress than healthy controls (ctl) during pregnancy or how these psychosocial factors influence their pregnancy. We investigated measures affecting pregnant without participating in the MECONIUM (Exploring MEChanisms Of traNsmission In Utero through Microbiome) Study. 34 (median age = 33, 62%CD, 88%white, median parity 2) 145...