A5083076498- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin and Cellular Biology Research
- Craniofacial Disorders and Treatments
- Urticaria and Related Conditions
- Cleft Lip and Palate Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Orthopedic Surgery and Rehabilitation
- Acute Myeloid Leukemia Research
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Hair Growth and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Genetic and rare skin diseases.
- Antibiotics Pharmacokinetics and Efficacy
- HIV Research and Treatment
- Autoimmune Neurological Disorders and Treatments
- Pleural and Pulmonary Diseases
- Orthodontics and Dentofacial Orthopedics
- Mitochondrial Function and Pathology
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
Nagoya Ekisaikai Hospital
2024-2025
Toho University
2014-2024
Tottori University
2024
Fukushima Medical University
2014-2022
Toho University Omori Medical Center
2021
Sunagawa City Medical Center
2020
Nakamura Memorial Hospital
2019
Hokkaido University
2019
Kagoshima University
2019
Japan Community Healthcare Organization
2017
In attempting to produce a mutant mouse with embryonic stem cells, the critical step is efficient isolation of homologous recombinants; frequency recombination usually low and potency cells differentiate into germ unstable in culture. Here, we report an efficacious method for such which diphtheria toxin A-fragment gene used negatively select nonhomologous recombinants. contrast use herpes simplex virus thymidine kinase gene, selection can be made singly by neomycin analog G418 without using...
High mobility group box 1 protein (HMGB1) is a chromatin that has dual function as nuclear factor and an extracellular factor. Extracellular HMGB1 released by damaged cells acts chemoattractant, well proinflammatory cytokine, suggesting tightly connected to the process of tissue organization. However, role in bone cartilage undergo remodeling during embryogenesis, repair, disease largely unknown. We show here stage-specific secretion regulates endochondral ossification. analyzed skeletal...
Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic class II molecules, such as human HLA-DQ8 and mouse I-Ag7, typically have a small, uncharged amino acid residue at position 57 of their beta chain (beta57); this results in the absence salt bridge between beta57 Argalpha76, which adjacent P9 pocket peptide-binding groove. However, influence Argalpha76 on selection TCR repertoire remains unknown, particularly when molecule binds peptide...
Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features nails. The aim this study was to clarify psoriasis identify those that reflect activity. During biologic treatment psoriasis, six with nails twice underwent examination, an interval 17-42 weeks. We used modified Nail Psoriasis Severity Index score Area assess features. identified 10 findings, which disappearance...
OBJECTIVE To compare the morphology of masseter muscle in patients with mandibular prognathism that normal subjects. METHODS Three-dimensional X-ray computed tomography (CT) was performed on 69 and compared 91 The angle direction relation to Frankfurt horizontal plane area ratio length short long axes (s/l ratio) section perpendicular were measured. RESULTS mean angle, s/l 76.6 degrees (s.d. 4.4 degrees), 318.3 mm2 77.2 mm2) 0.312 0.049), respectively. Those subjects 65.1 368.3 97.2 0.393...
We previously constructed a risk prediction model of vancomycin (VCM)-associated nephrotoxicity for use when performing initial therapeutic drug monitoring (TDM), using decision tree analysis. However, we could not build to be used at the time administration due insufficient sample size. Therefore, performed multicenter study four hospitals in Japan. investigated patients who received VCM intravenously standard dose from first day until TDM November 2011 March 2019. Acute kidney injury (AKI)...
The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This was applied AML modifier loci by association with microsatellite markers. region chromosome (chr) 18 strong identified confirmed backcross analysis. Additional chrs 8 13 show significant association. key candidate gene Rbbp8...
Diagnostic criteria were prepared for hypersensitivity pneumonitis (HP) and a nationwide survey was conducted to investigate epidemiological clinical characteristics of HP in Japan. The results are presented with special focus on occupational the key diagnosis HP.A questionnaire completed by 185 doctors from hospitals (response rate 89.5%). All cases verified according diagnostic criteria; 835 classified as (653 definite 182 probable). These (total HP) 99 possible diagnosed during 1980s...
To identify mutations in vacuolar protein sorting 13A (VPS13A) for Japanese patients with suspected chorea-acanthocytosis (ChAc).We performed a comprehensive mutation screen, including sequencing and copy number variation (CNV) analysis of the VPS13A gene, chorein Western blotting erythrocyte ghosts. As results analysis, 17 were molecularly diagnosed ChAc. In addition, we investigated distribution gene clinical symptoms total 39 ChAc, 22 previously reported cases.We identified 11 novel...
Abstract A case of hypersensitivity pneumonitis caused by a smut fungus Ustilago esculenta is presented.
Abstract α‐Taxilin has been identified as a binding partner of syntaxin family members and thus proposed to function in syntaxin‐mediated intracellular vesicle trafficking. However, the lack detailed information concerning cellular subcellular localization α‐taxilin impedes an understanding role this protein. In present study, we characterized α‐taxilin‐expressing cells rat CNS with specific antibody. During embryonic development, was prominently expressed nestin‐positive neural stem vivo...
Background Recently, cases of overlapping encephalitis caused by anti-N-methyl-D-aspartate receptor (anti-NMDAR) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been reported, their clinical characteristics are gradually becoming clear. Acute-phase treatment typically involves the use steroids, although some studies suggested that steroids can be effective, extent efficacy has not yet fully explored. Case presentation We present case a 25-year-old man with anti-NMDAR...
Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions autoantibodies and associated with relatively good prognosis. Pathological findings NMDAR usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report patient small cell lung cancer (SCLC)-related paraneoplastic antibodies, cytotoxic T-cell-mediated pathology the brain, rapid clinical course. This case highlights that...