A5074874156- Spine and Intervertebral Disc Pathology
- Spinal Hematomas and Complications
- Dermatologic Treatments and Research
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Hip and Femur Fractures
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Hematopoietic Stem Cell Transplantation
- Laser Applications in Dentistry and Medicine
- Tracheal and airway disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Alkaloids: synthesis and pharmacology
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Nasal Surgery and Airway Studies
- RNA modifications and cancer
- Artificial Intelligence in Healthcare and Education
- Circular RNAs in diseases
- Wound Healing and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Psychedelics and Drug Studies
- Protease and Inhibitor Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
Taihe Hospital
2016-2023
Shanxi Medical University
2015-2023
Sun Yat-sen University
2021-2023
Sun Yat-sen University Cancer Center
2021-2023
Hubei University of Medicine
2016-2023
State Key Laboratory of Oncology in South China
2023
Yuncheng University
2023
Army Medical University
2023
Qilu Hospital of Shandong University
2017
Zhejiang Sci-Tech University
2017
Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain, the treatment of IDD costly relatively ineffective. Dysregulation microRNAs (miRNAs) has been reported be involved in IDD. The purpose our study illustrate potential that miR-143-5p targeting eEF2 gene mediates Following establishment rat models, expression miR-143-5p, eEF2, Bcl-2, Bax, AMPK, mTOR, cyclinD, COL2, ACAN, DCN was detected. NP cells isolated from degenerative intervertebral (IVD)...
Emerging data have highlighted the importance of long noncoding RNAs (lncRNAs) in exerting critical biological functions and roles different forms brain cancer, including gliomas. In this study, we sought to investigate role lncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) glioma cells. First, used sphere formation assay flow cytometry select U251 stem cells (GSCs). Then, quantified expression FOXD2-AS1, TATA-box binding protein associated factor (TAF-1) NOTCH1 tissues GSCs, as well...
BACKGROUND:The myosin heavy chain 10 or MYH10 gene encodes non-muscle II B (NM IIB), and is involved in tumor cell migration, invasion, extracellular matrix (ECM) production, epithelial-mesenchymal transition (EMT). This study aimed to investigate the effects of on normal human glial cells glioma lines vitro, by silencing, determine signaling pathways involved. MATERIAL AND METHODS:The line HEB, lines, U251, T98G, SHG44 were studied. Plasmid transfection silenced gene. The counting kit-8...
Purpose . To evaluate the effects of different placements mesial implants and angles distant in maxillary edentulous jaws on stress implant surrounding bone tissue under dynamic loading. Materials Methods Cone beam computed tomography was used to acquire images jaws. Using Mimics 17.0, Geomagic, Unigraphics NX8.5 software, three-dimensional models were established: two placed vertically anterior region maxilla (bilateral central incisor, lateral canine), obliquely bilateral second premolar...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Concerns regarding data integrity were raised by National Science Library Chinese Academy Sciences, which based a PubPeer thread showing potentially hand-drawn flow cytometry histograms and western blots devoid background with sausage-shaped bands (https://pubpeer.com/publications/E73F538F46E201FF3575C965B5147E). The editors...
Purpose: To optimize the extraction conditions for ultrasound-assisted of polysaccharides from T. mongolicum (PTM) and investigate their anti-tumor effect on human breast cancer MCF-7 cells.Methods: PTM, response surface methodology (RSM) was performed. The effects temperature, liquid-solid ratio time yield PTM were investigated using a Box-Behnken design (BBD). in vitro cells by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay, while mechanism PTM-induced apoptosis assessed...
Abstract Maintaining the homeostasis of skin's immune microenvironment is crucial for health. In inflammatory skin conditions (like psoriasis), dysregulated, including reactive oxygen species (ROS) accumulation and T cell overactivation. addition to promoting inflammation excessive keratinocyte proliferation, ROS upregulation in psoriasis also induces glucocorticoid resistance, which poses a significant challenge effectiveness treatment (e.g., dexamethasone, Dex) psoriasis. To conquer this...
necrosis and apoptosis of the hypertrophic scar fibroblasts.Given our results, HMME might be an effective sound-sensitive agent for SDT as it has a significant lethal effect on fibroblasts rabbit ear cultured in vitro.HMME-SDT may therefore provide new method treatment formation.
Abstract Objective Endoscopic nasopharyngectomy (ENPG) with en bloc resection has been well accepted in resectable localized recurrent nasopharyngeal carcinoma (rNPC), but it is a difficult technique to master for most otorhinolaryngology head and neck surgeons. Ablation surgery new simplified method remove tumors. We designed novel using low‐temperature plasma radiofrequency ablation (LPRA) evaluated the survival benefit. Methods A total of 56 rNPC patients were explained detail...
To discuss clinical outcomes of accordion operation for the Ilizarov technique in treating tibial bone defects.From January 2014 to June 2016, 22 patients with defects were treated by bone-transport technique, including 19 males and 3 females an average age 44.04 years old ranging from 23 60 old;the length before transport was 5 11 cm 7.68 cm; Cause injury invlved traffic accidents 14 cases, fall 3, smashing 4, high drop 1; 6 cases on left 16 right. The divided into two groups: group...
Objective: To investigate the effect of aspirin on osseointegration around titanium implants in ostoeporotic rats and to provide evidence for future researches clinical application. Methods: A total 60 female SD rats, aged 3-4 months, were divided into ovariectomy group (Ovx group, n=48) sham-ovariectomy (Sham n=12). The Ovx received those Sham underwent sham-ovariectomy. Twelve weeks later, six each randomly selected confirm osteoporosis models. was 4 subgroups with 12 namely (OP group),...
Objective To explore the relationship between T-cell acute lymphoblastic leukemia and Notch signaling pathway. Methods Human SupT1 cells were infected with lentiviral vector made up specific Notch1-shRNA gene nonspecific gene.The inhibitive rate of was detected by CCK-8. The rates early apoptotic (Annexin V+/7-AAD-) late V +/7-AAD +) analyzed flow cytometry expression levels Notch1 receptor downstream target genes assessed quantitative reverse transcription polymerase chain reaction...
Abstract The immune system is constantly replenished by a rare population of hematopoietic stem cells (HSC) residing in the bone marrow adult organisms. E-proteins, widely expressed basic helix-loop-helix (bHLH) transcription factors, appear to contribute HSC activity, but their specific cell intrinsic functions remain undefined. In contrast recent report, we show that E47 dispensable for short-term myeloid differentiation HSCs. our quantitative assays, deficient progenitors competent...
Objective To investigate the mechanism of effect HMME-SDT on proliferation hypertrophic scar fibroblasts (Fb). Methods Fibroblast suspensions rabbit ear with were divided into four groups: control group, ultrasound HMME group and group. The survival fibroblast suspension determined by MTT assay method. mitochondrial membrane potential, cellular reactive oxygen, concentration changes calcium ion also investigated flow cytometry correspondingly. Nucleolar morphology was observed 33258...
Abstract Objectives: Endoscopic nasopharyngectomy (ENPG) with en bloc resection has been well accepted in resectable locally recurrent nasopharyngeal carcinoma (rNPC), but it is difficult to master the technique and disseminate. We designed a novel method using low-temperature plasma radiofrequency ablation (LPRA) piece evaluated survival benefit. Materials Methods: A total of 56 rNPC patients were retrospectively analyzed, following factors assessed: ratio R0 margin, overall rate (OS),...