A5003642094- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Intracerebral and Subarachnoid Hemorrhage Research
- CAR-T cell therapy research
- Allelopathy and phytotoxic interactions
- Functional Brain Connectivity Studies
- Sperm and Testicular Function
- Neonatal and fetal brain pathology
- Connective tissue disorders research
- Plant Stress Responses and Tolerance
- Biofuel production and bioconversion
- Bone and Dental Protein Studies
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Plant Parasitism and Resistance
- Ferroptosis and cancer prognosis
- Enzyme Production and Characterization
- Reproductive System and Pregnancy
- Ginkgo biloba and Cashew Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Vitamin K Research Studies
Xiamen University
2019-2024
Nanjing Tech University
2024
First Affiliated Hospital of Xiamen University
2022-2023
Central South University
2014-2023
Second Xiangya Hospital of Central South University
2014-2023
Cornell University
2023
Weill Cornell Medicine
2023
Nanjing Agricultural University
2014-2021
Hebei University of Engineering
2016
Fujian Agriculture and Forestry University
2014-2015
Abstract A multiple xylanase system with high levels of activity produced from Penicillium oxalicum GZ-2 using agricultural waste as a substrate has been previously reported. However, the eco-physiological properties and origin multiplicity xylanases remain unclear. In present study, eight active bands were detected zymography all identified putative MALDI-TOF-MS/MS. These are encoded by six different genes. To evaluate functions genes, xyn10A , xyn11A xyn10B xyn11B expressed in Pichia...
Endo-1,4-β-mannanase is an enzyme that can catalyze the random hydrolysis of β-1, 4-mannosidic linkages in main chain mannans, glucomannans and galactomannans has a number applications different biotechnology industries. Penicillium oxalicum powerful hemicellulase-producing fungus (Bioresour Technol 123:117-124, 2012); however, few previous studies have focused on cloning expression endo-1,4-β-mannanase gene from oxalicum. A encoding acidophilic thermostable (E.C. 3.2.1.78) GZ-2, which...
Protein nanocages are promising multifunctional platforms for nanomedicine owing to the ability decorate their surfaces with multiple functionalities through genetic and/or chemical modification achieve desired properties therapeutic and diagnostic purposes. Here, we describe a model antigen (OVA peptide) that was conjugated surface of naturally occurring hepatitis B core protein nanocage (HBc NC) by modification. The engineered OVA-HBc (OVA-HBc NCs), displaying high density repetitive array...
Abstract Advancing the integration of nonliving and living components relies heavily on functional hydrogel materials with biocompatibility customizability. In this study, an enzyme‐assisted surface activation method is developed to produce reactive microparticles (HMPs) comprising thiolated hyaluronic acid hyperbranched poly(β‐hydrazide esters). Fluorescence labeling analysis reveals over six‐fold increase in surface‐active group density hydrogels three‐fold HMPs after enzyme activation....
Abstract Rice allelopathy is a hot topic in the field of allelopathy, and behaviour donor allelopathic rice has been well documented. However, few study addresses response receiver barnyardgrass ( BYG ). We found that expression mi RNAs relevant to plant hormone signal transduction, nucleotide excision repair peroxisome proliferator‐activated receptor p53 signalling pathways was enhanced co‐cultured with cultivar PI 312777, levels these RNA s plants were positively correlated potential...
Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due to range genetic variants that prominently include mutations in genes encoding type I collagen. While it well known OI reflects defects the activity bone-forming osteoblasts, currently unclear whether also many other cell types comprising bone, including skeletal vascular endothelium or stem populations give rise osteoblasts correcting these broader could have therapeutic utility. Here, we find...
Glioma, a primary malignant tumor of the central nervous system, remains formidable challenge despite advancements in treatment. Immunotherapies hold promise, but their efficacy is hindered by blood-brain barrier (BBB) and immunosuppressive microenvironment (TME). The nose-to-brain transport pathway offers potential solution for bypassing BBB avoiding systemic absorption issues. In this study, we developed calcium phosphate (CaP)-covered nanovaccine (NV) based on hepatitis B core antigen...
To perform their antiviral and antitumor functions, T cells must integrate signals both from the cell receptor (TCR), which instruct to remain quiescent or become activated, cytokines that guide cellular proliferation differentiation. In mature CD8 + cells, Themis has been implicated in integrating TCR cytokine signals. We investigated whether plays a direct role signaling cells. was required for IL-2– IL-15–driven mice vitro. Mechanistically, we found promoted activation of transcription...
Psoriasis is a chronic inflammatory disease whose etiology directly related to the dysregulation of cutaneous immune homeostasis. However, how finely modulate skin microenvironment restore homeostasis remains an important challenge. Inspired by natural attribute tumor exosomes in escape, tumor-derived as active targeting nanoplatform for effective treatment disorder were first reported. As keratinocytes and cells express high PD-1 during onset psoriasiform inflammation, PD-L1-positive...
Abstract Aims Acute kidney injury (AKI) has been associated with a variety of neurological problems, while the neurobiological mechanism remains unclear. In present study, we utilized resting‐state functional magnetic resonance imaging (rs‐fMRI) to detect brain at an early stage and investigated impact microglia on neuropathological AKI. Methods Rs‐fMRI data were collected from AKI rats control group 9.4‐Tesla scanner 24, 48, 72 h post administration contrast medium or saline. The amplitude...
Molecular pathways controlling emigration of mature thymocytes from thymus to the periphery remain incompletely understood. Here, we show that T cell–specific ablation glycogen synthase kinase 3 (GSK3) led severely impaired thymic egress. In absence GSK3, β-catenin accumulated in cytoplasm, where it associated with and activated Akt, leading phosphorylation degradation Foxo1 downregulation Klf2 S1P1 expression, thereby preventing thymocytes. A cytoplasmic membrane-localized excluded nucleus...
Abstract Background: Psoriasis is a chronic and readily recurrent inflammatory skin disease. To date, there no cure for psoriasis significant challenges remain in developing more safe efficacious novel targeted therapies. characterized by abnormal activation of the immune system, hyperproliferation aberrant differentiation keratinocytes. Psoriatic keratinocytes death also recently recognized as major amplifier to initiation cascade. Given that both cells express high PD-1 psoriasis, which...
Abstract SHP-1 (Src homology region 2 domain-containing phosphatase 1) is a well-known negative regulator of T cells, whereas its close homolog SHP-2 the long-recognized main signaling mediator PD-1 inhibitory pathway. However, recent studies have challenged requirement in signaling, and follow-up further questioned alternative idea that may replace absence. In this study, we systematically investigate role alone or jointly with CD8+ cells series gene knockout mice. We show although...
Berberine, which is a traditional Chinese medicine can inhibit tumorigenesis by inducing tumor cell apoptosis. However, the immunoregulatory of effects berberine on T cells remains poorly understood. Here, we first examined whether prolong allograft survival regulating recruitment and function cells. Using major histocompatibility complex complete mismatch mouse heterotopic cardiac transplantation model, found that administration moderate doses (5 mg/kg) significantly prolonged heart to 19...
Abstract Maintaining the homeostasis of skin's immune microenvironment is crucial for health. In inflammatory skin conditions (like psoriasis), dysregulated, including reactive oxygen species (ROS) accumulation and T cell overactivation. addition to promoting inflammation excessive keratinocyte proliferation, ROS upregulation in psoriasis also induces glucocorticoid resistance, which poses a significant challenge effectiveness treatment (e.g., dexamethasone, Dex) psoriasis. To conquer this...
Previous studies have shown that Lycium barbarum polysaccharides (LBPs) serve an important role in antioxidant activity to protect the cells and tissues. However, specific mechanism of LBPs prevention endometrial damage remains be elucidated. Using morphological observation, cell proliferation assay, detection superoxide dismutase (SOD) content malondialdehyde (MDA) culture supernatant fluid, by western blot analysis reverse transcription-quantitative polymerase chain reaction mRNA protein...
The relationship between pregnancy and autoimmune diseases is unclear. This study investigated the possible role of local immune changes activation state HMGB1/TLR4/Nf-κB/IL-6 pathway at maternal–fetal interface during in pathogenesis acute disseminated encephalomyelitis (ADEM). Clinical data blood samples a patient with ADEM were collected to observe dynamic lymphocyte populations after an abortion. expression HMGB1, TLR4, Nf-κB, AQP4, IL-2, IL-4, IL-6, TNF-α fetal membrane placenta was...