A5102964849- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Concrete and Cement Materials Research
- Advancements in Semiconductor Devices and Circuit Design
- Nanowire Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Virology and Viral Diseases
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Neuroblastoma Research and Treatments
- Tailings Management and Properties
- Animal Virus Infections Studies
- Polymer Surface Interaction Studies
- Bauxite Residue and Utilization
- Analytical Chemistry and Sensors
- Ferroptosis and cancer prognosis
- Advanced Physical and Chemical Molecular Interactions
- Nanocomposite Films for Food Packaging
- Magnesium Oxide Properties and Applications
Weifang University of Science and Technology
2024-2025
Shanghai Normal University
2023-2025
Ocean University of China
2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
Jinan Institute of Quantum Technology
2024
Sichuan University
2019-2024
Chinese Academy of Sciences
2015-2024
Weifang University
2022-2024
Suzhou Institute of Biomedical Engineering and Technology
2021-2024
Glioblastoma (GBM) remains one of the most malignant primary tumors in adults, with a 5-year survival rate less than 10% because lacking effective treatment. Here, we aimed to explore whether B7-H3 could serve as novel therapeutic target for GBM chimeric antigen receptor (CAR) T cell therapy. In this study, CAR targeting was constructed and transduced into cells by lentivirus. Antitumor effects B7-H3-specific CAR-T were assessed lines both vitro vivo. Our results indicated that positively...
Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized combinatorial targeting two tumor-associated would lessen this problem enhance the antitumor activity T cells. Methods:The co-expression level CD70 B7-H3 was analyzed in multiple tumor tissue samples.Further, putative were identified The Cancer Genome Atlas Gene Expression Profiling Interactive Analysis...
Recently, B7-H3 was frequently reported to be overexpressed in various cancer types and has been suggested a promising target for immunotherapy. In the present study, we analyzed mRNA expression of The Cancer Genome Atlas (TCGA) database validated its across multiple types. We then generated novel B7-H3-targeted chimeric antigen receptor (CAR) tested antitumor activity both
Overcoming tumor antioxidant defenses remains a critical challenge for reactive-oxygen-species-mediated therapies. To address this problem, herein, theranostic nanomedicine designated as CCM@MIB has been elaborately constructed. Homologous cancer cell membrane (CCM) camouflage significantly enhances the selective accumulation of at sites. In response to microenvironment (TME), controllably releases Mn ions and sulfur dioxide (SO2) molecules. The released catalyze self-oxidation isoniazid...
A cold atmospheric-pressure plasma, which has been widely used for biomedical applications, may potentially affect the cell cycle and cause apoptosis. In this paper, a human hepatocellular carcinoma (HepG2) is treated by single-electrode plasma jet device. Further investigation using flow cytometric analysis demonstrates that treatment increases percentage of apoptotic cells being associated with arrest at G2/M phase. Moreover, reverse transcription polymerase chain reaction assay shows...
Patients with mild cognitive impairment (MCI) are at high risk of dementia, but early identification and active intervention can reduce its morbidity the incidence dementia. There is currently no suitable neuropsychological assessment scale to effectively identify MCI in neurological outpatient departments China. The Mini-Mental State Examination (MMSE) often used screen for China.To compare value Mini-Cog MMSE screening patients a department, determine differences different ages educational...
Abstract Objective We conducted a first‐in‐human study to evaluate the bioactivity and safety of B7‐H3‐targeted chimeric antigen receptor (CAR) autologous T cells for treating recurrent anaplastic meningioma. Methods Tumor tissues from patient with meningioma were evaluated B7‐H3 expression. CAR‐T delivered into intracranial tumor resection cavity using an Ommaya device at maximum dose 1.5 × 10 7 cells. Magnetic resonance imaging (MRI) screening multiple serum indexes regularly monitored....
Chemotherapy works against tumors by inducing cell apoptosis; however, evasion of apoptosis is recognized to result in resistance anticancer therapy. Ferroptosis an iron-dependent death pathway that differs from morphological, biochemical, and genetic levels. Combined ferroptosis may shed light on strategies for cancer treatment. Therefore, we have designed a nanoparticle (NP) can simultaneously cause tumor ferroptosis. This NP composed epigallocatechin gallate (EGCG) Fe3+ through simple...
Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents cause severe systemic toxicity. Here, we have developed dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which achieve controlled release of clinical levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant P. aeruginosa. Benefiting from the...
Triple-negative breast cancer (TNBC) comprises lethal malignancies with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy is an effective immunotherapeutic strategy that has demonstrated unprecedented efficacy in the of hematological but shown success management some solid tumors. Many malignant tumors are related to increased expression intercellular adhesion molecule-1 (ICAM1), providing a rationale for ICAM1-specific immunotherapies cancer. Here, we validated...
Traditional microtubule inhibitors fail to significantly enhance the effect of colorectal cancer; hence, new and efficient strategies are necessary. In this study, a supramolecular nanoreactor (DOC@TA-Fe3+) based on tannic acid (TA), iron ion (Fe3+), docetaxel (DOC) with inhibition, reactive oxygen species (ROS) generation, glutathione peroxidase 4 (GPX4) is prepared for ferroptosis/apoptosis treatment. After internalization by CT26 cells, DOC@TA-Fe3+ escapes from lysosomes release payloads....
Abstract Background Chimeric antigen receptor (CAR) T cells and immune checkpoint blockades (ICBs) have made remarkable breakthroughs in cancer treatment, but the efficacy is still limited for solid tumors due to tumor heterogeneity microenvironment. The restrained treatment prompted us seek new potential therapeutic methods. Methods In this study, we conducted a small molecule compound library screen human BC cell line identify whether certain drugs contribute CAR killing. Signaling...
A novel NaOH modified eggplant straw biochar supported green nanoscale zerovalent iron (P-nZVI/ESBC) composite was synthesized and its removal performance reaction mechanism for tetracycline (TC) in water were investigated. Multiple characterizations showed that the prepared P-nZVI/ESBC contained oxygen-containing functional groups (hydroxyl, carbonyl, carboxyl groups) Fe species (nZVI oxides). The dosage of composite, temperature, solution pH significantly affected capacity TC. Avrami...
Craniopharyngioma (CP) is a common refractory tumor of the central nervous system. However, little known about expression and clinical significance B7 family ligands/receptors in CP patients. Thus, we conducted present study to address this issue cohort 132 cases.We mapped quantified molecules programmed cell death ligand 1 (PD-L1), B7-H3, B7-H4 V-domain Ig-containing suppressor T activation (VISTA) 89 adamantinomatous-type 43 papillary-type samples using immunohistochemistry...
Utilizing aluminosilicate-rich mine tailings via geopolymerization provides a desirable solution for decreasing the inventory when limitation of low activity is addressed with cost-effective technology. Alkali-hydrothermal pretreatment can effectively enhance at temperature ~200 °C, much lower than traditional activation methods such as high-temperature calcination and alkali fusion. However, only geopolymers prepared from activated high NaOH concentrations during process show satisfactory...