Background: The optimal antithrombotic strategy for patients with atrial fibrillation (AF) undergoing drug-eluting stent (DES) implantation is unknown. Methods and Results: 622 consecutive AF DES were prospectively enrolled. Among them, 142 (TT group) continued triple therapy comprising aspirin, clopidogrel warfarin after discharge; 355 (DT had dual antiplatelet therapy; 125 (WS discharged a single agent. Target INR was set as 1.8-2.5 regularly monitored discharge. TT group significant...

To evaluate the effects of dulaglutide vs placebo on liver and glycaemic/metabolic measurements in a population with Type 2 diabetes subgroup non-alcoholic fatty liver/non-alcoholic steatohepatitis.A total 1499 participants from AWARD-1, AWARD-5, AWARD-8 AWARD-9 clinical trials were included this analysis (dulaglutide 1.5 mg, n=971 placebo, n=528). Thresholds alanine aminotransferase levels ≥30 IU/l men ≥19 women used to determine who had steatohepatitis. Objectives changes baseline 6 months...

Aims To evaluate the efficacy and safety of dulaglutide 1.5 0.75 mg in elderly patients (aged ≥65 years) with type 2 diabetes ( T2D ) six phase III clinical trials. Methods Patients were grouped into two age groups: <65 years. Pooled analysis for glycated haemoglobin HbA1c change from baseline, percentage achieving targets, gastrointestinal tolerability evaluated at 26 weeks each dose. Change weight baseline rates hypoglycaemia individual study. Results A total 958 5171 (18.5%) aged The...

Aims To compare treatment satisfaction among people with type 2 diabetes receiving dulaglutide 1.5 mg and 0.75 (a once‐weekly, long‐acting, glucagon‐like peptide‐1 receptor agonist) those either exenatide or placebo ( AWARD ‐1 study) metformin ‐3 over 52 weeks. Methods The D iabetes T reatment S atisfaction Q uestionnaire status version DTSQs ) change DTSQc were used to evaluate total perceived frequency of hyperglycaemia hypoglycaemia. Results In the study, significant improvements from...

Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study date has directly examined effect obesity on cardiovascular thrombotic events after stent implantation.To evaluate in patients undergoing PCI with drug-eluting stents.We studied 4972 between January 2004 and December 2006. Patients were divided into three groups according index: normal (BMI <24.9 kg/m(2), n = 1284),...

Abstract Aims To test the hypothesis that glycaemic control achieved when switching sitagliptin to exenatide twice daily plus metformin is non‐inferior adding and metformin. Methods Patients with Type 2 diabetes inadequately controlled were randomly assigned 20 weeks of treatment twice‐daily placebo (SWITCH, n = 127) or (ADD, 128). Results Non‐inferiority (0.4% margin) SWITCH ADD treatment, measured by change in HbA 1c from baseline week 20, was not shown {between‐treatment difference...

We evaluated patient‐reported outcome ( PRO ) measures from the Assessment of Weekly AdministRation LY2189265 (dulaglutide) in Diabetes AWARD clinical trial programme for dulaglutide (1.5 mg and 0.75 mg) patients with type 2 diabetes T2D ). The Impact Weight on Self‐Perception IW‐SP ), Ability to Perform Physical Activities Daily Living APPADL Quality Life‐Lite, EQ‐5D , Treatment Satisfaction Questionnaire DTSQ Symptom Checklist‐Revised Adult Low Blood Sugar Survey were administered analysed...

We evaluated reduced back pain in a multiethnic population treated with teriparatide and/or antiresorptives real-life clinical settings over 12 months. METHODSThis prospective observational study comprised 562 men and postmenopausal women (mean age 68.8 years) receiving either (n = 230), (raloxifene or bisphosphonates; n 322), both 10) for severe osteoporosis.The primary endpoint was the relative risk of new/worsening at six RESULTSAt baseline, higher proportion teriparatide-treated than...

Insomnia is a common prevalent sleep disorder. Difficulty maintaining or poor in quality insomnia caused by disrupted misaligned circadian rhythms may play an important role the development of atherosclerosis. This study aimed to examine association between and subclinical atherosclerosis Chinese steelworkers.A total 3240 subjects from large enterprise located northern China were included this study. The Athens Scale (AIS) was used assess status insomnia. Subclinical evaluated using...

Abstract Non-alcoholic fatty liver disease (NAFLD) is replacing hepatitis B as the leading cause of chronic in China. The purpose this study to select good tools identify NAFLD from body composition, anthropometry and related routine clinical parameters. A total 5076 steelworkers, aged 22–60 years, was included study. Body fat mass measured via bioelectrical impedance analysis (BIA) index (FMI) derived. Ultrasonography method used detect hepatic steatosis. Random forest classifier best...

The aim of this study was to evaluate the associations rotating night shift work with body fat percentage (BF%) and mass index (FMI). A cross-sectional conducted among 435 female steelworkers, aged 26–57 years in Tangshan, China. BF% assessed via bioelectrical impedance analysis FMI calculated. Different exposure metrics were used examine effects on FMI. duration (years), cumulative number (nights), length shifts (hours) positively correlated BF%, these relationships independent (BMI)....

Occupational exposure to heat stress and noise at the workplace are widespread physical hazards have been associated with an increase in both morbidity mortality. This study aims examine association between occupational carotid atherosclerosis Chinese steelworkers. A total of 3471 subjects were included this study. Carotid plaque was measured using ultrasonography. The information collected by face-to-face personal interviews all reported verified company's records. Workers divided into...

Many studies have indicated that metabolic disorders are positively correlated with idiopathic venous thromboembolism (VTE), whereas the risk factor serum uric acid (SUA) for VTE has yet to be investigated. In this retrospective case-control study, 276 patients and 536 gender- age-matched control subjects were included. The in case groups exhibiting common known factors a first onset one month excluded. For group, primary secondary High‑density lipoprotein cholesterol (HDL-C), low-density...

This study aimed to investigate the association between metabolically healthy obesity (MHO) and carotid plaque. In this cross-sectional survey, 3467 steelworkers in North China were surveyed. There are two criteria for defining a plaque: (1) lesion structure exceeds 50% of peripheral intima-media thickness value or invades arterial lumen by at least 0.5 mm; (2) > 1.5 mm from intima−lumen interface media−adventitia interface. Metabolic health was defined as nonexistence one metabolic syndrome...

The purpose of this study was to determine whether neck circumference (NC) is associated with subclinical atherosclerosis among Chinese steelworkers in North China. A cross-sectional survey conducted northern China (n = 3467). Carotid intima-media thickness (CIMT) measured at the distal wall common carotid artery proximal bifurcation point along a plaque-free segment 10 mm long on each side by B-ultrasound. mean CIMT used bilaterally study. In analysis, large NC presence abnormal CIMT....

To examine whether obesity has a similar effect on long-term prognosis between men and women undergoing percutaneous coronary intervention (PCI).We separately examined 3926 2157 PCI with drug-eluting stents January 2004 December 2006. All the patients were categorized according to BMI: normal weight (<25 kg/m(2)), overweight (25-29.9 obese (≥30 kg/m(2)). The primary endpoint was major adverse cardiovascular events (MACE), defined as composite of cardiac death nonfatal myocardial infarction....

To examine the association and potential mediators between rotating night shift work serum lipid profiles in Chinese steelworkers.Different exposure metrics of shifts collected through face-to-face personal interviews. Serum were measured using an automatic biochemical analyzer. Generalized linear models mediation analyses used to analyze main associations.Compared with day workers, total cholesterol level night-shift workers increased those 13 20 years average frequency four or more per...

This study aims to investigate the association between metabolically healthy obesity (MHO) and early stages of renal dysfunction whether systemic inflammation affects study's outcome. Male steelworkers in northern China were investigated this cross-sectional survey (n = 6309). A decrease estimated glomerular filtration rate (eGFR) was used as primary outcome, which defined an eGFR ≤89 mL/min/1.73 m2. BMI ≥ 25 kg/m2 determine obesity. In definition metabolic health, absence syndrome...

The research examined the antioxidative impact of astragalosides (AST) on experimental acute pancreatitis (AP) in mice. This study aims to assess correlation between varying doses and superoxide dismutase (SOD) activity an mouse model. By examining interplay astragaloside's protective effects its antioxidant properties, we aim deepen our understanding therapeutic potential pancreatitis.

We propose and experimentally demonstrate a MAC-assisted DSP for tri-rate upstream reception of 50G PON, which greatly reduces preamble time achieves requirements power budget C+ class BTB 20km transmission.

This study aimed to investigate the changes in bioactive peptides (BPs) of buffalo milk cheese (BMC) within 15 days storage. A total 3605 were identified BMC, with 260 remaining stable for days. Among these, peak intensities all reported BPs (9 peptides) increased on 15th day. Additionally, two novel antioxidant peptides, AYF (IC