A5041316228- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Stress Responses and Cortisol
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Respiratory Support and Mechanisms
- Eating Disorders and Behaviors
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Retinal Imaging and Analysis
- Eicosanoids and Hypertension Pharmacology
- Traditional Chinese Medicine Studies
- Health and Lifestyle Studies
- Cancer, Lipids, and Metabolism
- Cardiovascular Issues in Pregnancy
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Cardiac Health and Mental Health
- Shoulder and Clavicle Injuries
- Connexins and lens biology
- Delphi Technique in Research
- Physical Activity and Health
- Global Health Workforce Issues
Thomas Jefferson University
2015-2022
Bryn Mawr Hospital
2022
University of Toronto
2014-2021
National Institute of Diabetes and Digestive and Kidney Diseases
2015-2016
National Institutes of Health
2015-2016
American Physical Therapy Association
2014
Center for Translational Molecular Medicine
2014
New York University
2011-2013
Lipid-laden macrophages, or "foam cells," are observed in the lungs of patients with fibrotic lung disease, but their contribution to disease pathogenesis remains unexplored. Here, we demonstrate that fibrosis induced by bleomycin, silica dust, thoracic radiation promotes early and sustained accumulation foam cells lung. In bleomycin model, show arise from neighboring alveolar epithelial type II cells, which respond injury dumping lipids into distal airspaces lungs. We oxidized phospholipids...
Objectives Obesity is on the rise in US and linked to development of type 2 diabetes cardiovascular disease. Emerging evidence over last decade suggests that obesity may also adversely affect executive function brain structure. Although a great deal research focuses how diet affects cognitive performance, no study food choice be associated with integrity. Here we investigated lean overweight/obese (o/o) adults differed their choices structure cognition those choices. Design As part an...
Abstract Obesity is a risk factor for the development of acute respiratory distress syndrome (ARDS) but mechanisms mediating this association are unknown. While obesity known to impair systemic blood vessel function and predisposes vascular diseases, its effects on pulmonary circulation largely We hypothesized that chronic low grade inflammation impairs homeostasis primes lung injury. The endothelium from obese mice expressed higher levels leukocyte adhesion markers lower cell-cell...
OBJECTIVE Slowing the diabetes epidemic in Africa requires improved detection of prediabetes. A1C, a form glycated hemoglobin A, is recommended for diagnosing The proteins, fructosamine and albumin (GA), are hemoglobin-independent alternatives to but their efficacy Africans unknown. Our goals were determine ability fructosamine, GA detect prediabetes U.S.-based value combining A1C with either or GA. RESEARCH DESIGN AND METHODS Oral glucose tolerance tests (OGTT) performed 217 self-identified...
Abstract BACKGROUND Following immigration to the US, many Africans transition from a low-normal high-normal or overweight body mass index (BMI). This weight change is associated with high rate of prediabetes in nonobese. Studies East Asians reveal that glycated albumin effective identifying nonobese Asians. Whether this true African immigrants unknown. Therefore, we evaluated ability hemoglobin A1c (Hb A1c) and detect (BMI <30 kg/m2) obese ≥30 immigrants. METHODS Oral glucose...
Chronic alcoholism impairs pulmonary immune homeostasis and predisposes to inflammatory lung diseases, including infectious pneumonia acute respiratory distress syndrome. Although has been shown alter hepatic metabolism, leading lipid accumulation, hepatitis, and, eventually, cirrhosis, the effects of alcohol on metabolism remain largely unknown. Because both liver actively engage in synthesis, we hypothesized that chronic would impair metabolic ways similar its liver. We reasoned...
Introduction: Allostatic load score (ALS) summarizes the physiological effect of stress on cardiovascular, metabolic and immune systems. As immigration is stressful, ALS could be affected. Objective: Associations age immigration, reason for unhealthy assimilation behavior with were determined in 238 African immigrants to United States (US) (age 40±10, mean±SD, range 21-64y). Methods: was calculated using ten variables from three domains; cardiovascular (SBP, DBP, cholesterol, triglyceride,...
Endothelial dysfunction in childhood obesity may precede cerebrovascular damage and cognitive impairment adulthood. A noninvasive proxy of microvascular health is required to identify the risk for obese children.The associations hippocampal volumes global cerebral atrophy were assessed with retinal vessel caliber 40 normal BMI controls 62 age-matched nondiabetic adolescents contribution inflammation, obesity, insulin resistance was evaluated.Compared controls, had smaller arterioles (8.3%...
To develop and evaluate a preliminary clinical decision-making tool (CDMT) to assist physiotherapists in titrating oxygen for acutely ill adults Ontario.A panel of 14 experienced cardiorespiratory was recruited. Factors relating titration were identified using modified Delphi technique. Four rounds questionnaires conducted, during which the goals (1) generate factors, (2) reduce factors debate contentious (3) finalize CDMT, (4) usability context.The reached consensus on total 89 compiled...
Previous works on experience-dependent brain plasticity have been limited to the cortical structures, overlooking subcortical visual structures such as lateral geniculate nucleus (LGN). Animal studies shown substantial experience dependent and using fMRI, human demonstrated similar properties in patients with cataract surgery. However, neither animal nor LGN has not directly assessed, mainly due its small size, tissue heterogeneity, low contrast/noise ratio, spatial resolution.Utilizing a...
Levels of physical activity (PA), an important risk factor for cardiometabolic disease, may decline in Africans after immigration and it is unknown whether PA type differs by sex. To determine profile perceived African immigrants, we examined intensity using the self-report Multi-Ethnic Study Atherosclerosis (MESA) Typical Week Physical Activity Survey (TWPAS). levels were defined as time spent total moderate-vigorous 80 immigrants living DC metro area, who self-identified healthy (66% male;...
As both diabetes and pre-diabetes are common in Africa, screening tests must be rapid, simple, accurate. Hemoglobin A1C (A1C), fructosamine, glycated albumin (GA) of long term glycemia which only require one blood sample obtained any time day without consideration recent nutrient intake. is already recommended as a test for by the American Diabetes Association International Federation, but fructosamine GA under active evaluation. Fructosamine measure circulating protein. subfraction...
Introduction: Immigration from Africa to the United States is stressful. Stress causes cardiovascular (CV), metabolic and immune dysregulation. Allostatic load score (ALS) quantifies effect of dysregulation in these 3 systems. Objective: Our goal was determine influence age immigration, reason for immigration unhealthy assimilation behavior on ALS 238 African immigrants (AI) (age 40±10, mean±SD, range 21-64y). Methods: calculated using 10 variables, 6 were CV (SBP, DBP, triglyceride,...
African immigrants living in the United States are exposed to stress of changing continents and cultures. Therefore two types environmental stress; first, related navigating new social economic realities; second, due work, education a sedentary lifestyle States. To evaluate effect these stressors on health, we calculated allostatic load score groups Africans: childhood who came before 18 years age, adulthood at age or older. Allostatic is measure influence physiological function. It for each...