A5030242093- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Nanoplatforms for cancer theranostics
- Sports injuries and prevention
- Lower Extremity Biomechanics and Pathologies
- Hip and Femur Fractures
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Orthopaedic implants and arthroplasty
- Venous Thromboembolism Diagnosis and Management
- Foot and Ankle Surgery
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Nerve injury and regeneration
- Cardiac, Anesthesia and Surgical Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Bone Tissue Engineering Materials
- Advanced Photocatalysis Techniques
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2025
Third Hospital of Hebei Medical University
2020-2023
Hebei Medical University
2020-2023
Wuhan University of Science and Technology
2022-2023
Nankai University
2020-2022
Hospital of Hebei Province
2022
East China Normal University
2022
Southwest Medical University
2021
Affiliated Hospital of Southwest Medical University
2018-2021
The immune microenvironment extensively participates in tumorigenesis as well progression osteosarcoma (OS). However, the landscape and dynamics of cells OS are poorly characterized. By analyzing single-cell RNA sequencing (scRNA-seq) data, which characterize transcription state at resolution, we produced an atlas OS. results suggested that a cluster regulatory dendritic (DCs) might shape immunosuppressive by recruiting T cells. We also found major histocompatibility complex class I (MHC-I)...
This study aimed to describe the epidemiologic characteristics of fracture in elderly during COVID-19.This was a retrospective multi-centre study, which included patients who sustained fractures between 20 January and 19 February 2020. The collected data patients' demographics (age gender), injury-related (injury type, location, injury mechanism, places where occurred), treatment modality. SPSS 23.0 used perform some analysis.A total 436 with 453 were included; there 153 males 283 females,...
Abstract Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains largely unknown. Accumulating evidence indicates that central nervous system (CNS) plays a pivotal role in regulating immune and skeletal homeostasis. However, impact of CNS on hematopoiesis commitment was overlooked. Here, we found dramatically elevated sympathetic tone accompanied with TBI-accelerated healing; chemical sympathectomy blocks TBI-induced healing. hypersensitivity...
Abstract Skeletal muscle loss is a common clinical disease, whose long treatment period and expensive costs bring heavy burden to patients. Currently, the use of piezoelectric materials generate in situ efficient electrical stimulation has been proven significantly promote wound healing other defects. However, skeletal requires repaired with high elastic deformation accompany its reciprocating movement during process. Therefore, developing biocompatible that combine piezoelectricity...
Abstract Tendon stem/progenitor cells (TSPCs) therapy is a promising strategy for enhancing cell matrix and collagen synthesis, regulating the metabolism of tendon microenvironment during injury repair. Nevertheless, barren gliding shear cause insufficient nutrition supply, damage, aggregation injected TSPCs around tissues, which severely hinders their clinical application in tendinopathy. In this study, delivery system developed by encapsulating within DNA hydrogel (TSPCs‐Gel) as offers an...
Background: Although systemic chemotherapy is a standard approach for osteosarcoma (OS) treatment, its efficacy limited by the inherent or acquired resistance to apoptosis of tumor cells. Ferroptosis considered as an effective strategy capable stimulating alternative pathways cancer cell demise. The purpose this study develop novel boosting ferroptotic cascade synergistic therapy. Methods and Results: A nanovehicle composed arginine-glycine-aspartate (RGD) modified mesoporous silica-coated...
The oxidative stress microenvironment and mitochondrial dysfunction in chondrocytes are key mechanisms the development of osteoarthritis (OA). Metformin (Met) has demonstrated multiple effects on mitochondria is regarded as a potential therapeutic agent for OA. low blood flow characteristics joint cavity make targeted local delivery metformin crucial its clinical application. In this study, tannic acid (TA), with natural antioxidant anti-inflammatory properties, was used to prepare...
The synergistic effects of photothermal therapy (PTT) and photodynamic (PDT) has attracted considerable attention in the field cancer because its excellent anti-tumor effect. This work provides a novel pH/NIR responsive therapeutic nanoplatform, IrO2@ZIF-8/BSA-FA (Ce6), producing effect PTT-PDT treatment osteosarcoma. Iridium dioxide nanoparticles (IrO2 NPs) with exceptional catalase-like activity PTT were synthesized by hydrolysis method decorated zeolitic imidazolate framework-8 (ZIF-8)...
Chronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) inflammation is a major contributing factor difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel composed ε-polylysine grafted (EPL) with caffeic acid (CA) hyaluronic (HA) phenylboronic (PBA). Before gelation process, mixture CaO2@Cur-PDA (CCP) consisting calcium peroxide (CaO2) coated polydopamine...
Abstract Background Although lower temperature (< 45 °C) photothermal therapy (LPTT) have attracted enormous attention in cancer therapy, the therapeutic effect is still unsatisfying when applying LPTT alone. Therefore, combining with other therapies urgently needed to improve of LPTT. Recently reported oxygen-irrelevant free radicals based thermodynamic (TDT) exhibit promising potential for hypoxic tumor treatment. However, overexpression glutathione (GSH) cells would potently scavenge...
Currently, the use of piezoelectric materials to provide sustainable and noninvasive bioelectric stimulation eradicate tumor cells accelerate wound healing has raised wide attention. The development a multifunctional elastomer with ability perform in situ therapy as well repair is paramount importance. However, current have large elastic modulus limited stretchability, making it difficult match dynamic curvature changes wound. Therefore, by copolymerizing lactic acid, butanediol, sebacic...
Abstract Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental defects through autologous transplantation often encounters challenges such as axonal mismatch suboptimal functional recovery. These issues may stem from limited regenerative capacity proximal axons subsequent Wallerian degeneration distal axons. To achieve integration functions, a spatially differential plasmid DNA (pDNA) dual‐delivery nanohydrogel...
Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, therapeutic efficacy current protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance severe side effects. Amplification intracellular oxidative stress considered as an effective strategy to induce cancer cell death. The purpose this study was develop a novel that can amplify synergistic cascade therapy.A nanocomposite, composed folic acid (FA) modified mesoporous silica-coated...
The TFAB NPs integrate photothermal, chemodynamic, and thermodynamic therapies, effectively enhancing tumor treatment by generating reactive oxygen species controlling intracellular environments.
Critical peripheral nerve deficiencies present as one of the most formidable conundrums in realm clinical medicine, frequently culminating structural degradation and derangement neuromuscular apparatus. Engineered extracellular vesicles (EVs) exhibit potential to ameliorate impairments. However, advent Wallerian degeneration (WD), an inexorable phenomenon that ensues post injury, serves insurmountable impediment direct therapeutic efficacy EVs. In this investigation, we have fashioned a...
Abstract Background Limited information exists on the incidence of postoperative deep venous thromboembolism (DVT) in patients with isolated patella fractures. The objective this study was to investigate and locations thrombosis lower extremity who underwent fractures identify associated risk factors. Methods Medical data 716 hospitalized collected. had acute were admitted at 3rd Hospital Hebei University between January 1, 2016, February 31, 2019. All met inclusion criteria. collected using...
The purpose of this study was to evaluate the clinical and radiographic outcomes after medial patellofemoral ligament (MPFL) reconstruction combined with supracondylar biplanar femoral derotation osteotomy (FDO) in recurrent patellar dislocation (RPD) increased anteversion angle (FAA) genu valgum.Between January 2017 December 2020, a total 13 consecutive patients (13 knees, 4 males 9 females, mean age 18.7 (range, 15-29 years) RPD FAA (FAA > 25°) valgum (mechanical axis deformity ≥5°) who...
Abstract Phase fraction is one of important indexes to characterize multiphase flow. In order measure each phase oil–gas–water three-phase flow, liquid level height detected by time-of-flight—TOF reflected ultrasound at gas – interface, while oil in reflection path calculated according the attenuation. By studying interactions between flow and propagation certain patterns, a prediction model for measurement proposed based on transmission attenuation TOF process horizontal with actual...