A5066020683- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Genetic and Kidney Cyst Diseases
- Esophageal and GI Pathology
- Mycobacterium research and diagnosis
- Gallbladder and Bile Duct Disorders
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Breast Cancer Treatment Studies
- Congenital Diaphragmatic Hernia Studies
- Advanced Breast Cancer Therapies
Asan Medical Center
2014-2025
University of Ulsan
2014-2025
Ulsan College
2014-2025
Yahoo (United Kingdom)
2025
Seoul Medical Center
2024
Catholic University of Daegu
2019-2021
Daegu Catholic University Medical Center
2019
Eastern Hepatobiliary Surgery Hospital
2018
Second Military Medical University
2018
The large volume of adult living donor liver transplantations (ALDLTs) at our center affords a unique opportunity to examine the impact acute-on-chronic failure (ACLF) among high-Model for End-Stage Liver Disease MELD score patients. From February 1998 March 2010, 1958 cirrhotic recipients were analyzed study relationship between scores and ALDLT outcomes. A total 327 high-MELD categorized into ACLF non-ACLF groups, their outcomes compared. 5-year graft patient survival in group 75.2% 76.4%,...
Abstract Hepatitis B Virus (HBV) infection significantly elevates the risk of hepatocellular carcinoma (HCC), with HBV X protein (HBx) playing a crucial role in cancer progression. Sorafenib, primary therapy for advanced HCC, shows limited effectiveness HBV‐infected patients due to HBx‐related resistance. Numerous studies have explored combination therapies overcome this Sodium diethyldithiocarbamate (DDC), known its anticancer effects and inhibition superoxide dismutase 1 (SOD1), is...
Compared to overall survival, conditional survival is a more relevant measure of prognosis in surviving patients over time. This study developed and validated nomogram-based dynamic prognostic model predict the estimates with hepatocellular carcinoma (HCC) through an analysis nationwide cancer registry. retrospective cohort included 2492 HCC registered Korea Liver Cancer Registry. Patients underwent hepatic resection (HR) from 2008 2017, were followed up until December 2019, divided into...
Split-liver transplantation (SLT) should be cautiously considered because the right trisection (RTS) graft can a marginal in adult recipients. Herein, we analyzed outcomes of RTS-SLT Korea, where >75% liver transplantations are performed with living donor transplantation. Among 2462 patients who underwent deceased (DDLTs) from 2005 to 2014, retrospectively reviewed 86 (3.5%) received RTS (RTS-SLT group). The group were compared those 303 recipients whole (WL; WL-DDLT Recipient age,...
Pelvic lymph node (LN) status after preoperative chemoradiotherapy (CRT) is an important indicator of oncologic outcome in patients with locally advanced rectal cancer. The purpose this study was to develop a nomogram predict LN CRT cancer patients. developed training cohort (n=891) using logistic regression analyses and validated validation (n=258) from prospectively registered tumour registry at Asan Medical Center. model internally externally for discrimination calibration bootstrap...
Both sorafenib and mammalian target of rapamycin inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence. We performed a laboratory using mTORi subsequently validated survival benefit clinical LT setting. In the study, HepG2.2.15 tumor cell line 5 patient‐derived graft HCC lines were used for vitro cytotoxic studies. After treatment everolimus sorafenib, viability apoptosis...
Objective: This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) open (ODRH). Background: Donor recipient have not been sufficiently reported in large-scale comparisons PLDRH ODRH. Methods: retrospective reviewed 3348 who underwent (n=329) ODRH (n=3019) their corresponding (n=3348) between January 2014 August 2023. complications biliary within 90 days were evaluated before 1:3 propensity score mathcing (PSM)....
Background. Acquired diaphragmatic hernia (DH) is a rare and potentially fatal complication after living donor hepatectomy (LDH). This study aimed to assess the incidence clinical outcomes of DH LDH. Methods. Four thousand fourteen donors who underwent LDH at Asan Medical Center, Seoul, between September 2013 August 2023 were retrospectively reviewed. We analyzed before introduction bipolar irrigated sealer (BIS). Multivariate logistic regression analysis was used identify risk factors for...
Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) account for 5%-10% of liver cystic diseases. In this study, we analysed the clinical presentation surgical management patients with BCA BCAC.We retrospectively medical records 23 7 BCAC cases diagnosed between January 2007 December 2013.There was a statistically significant difference in age (p=0.044) sex (p=0.048) groups. group, 17 showed no symptoms (74%), 5 had abdominal pain (22%) 1 distension (4%). two were without any...
Background/Aim: We investigated metformin-induced cytotoxic effects in vitro and assessed the chemopreventive of metformin patients undergoing hepatic resection (HR) for hepatocellular carcinoma (HCC). Materials Methods: This study consisted laboratory clinical studies. Results: In using HCC cell lines revealed noticeable metformin, that were largely weaker than those sorafenib. study, no statistical differences found tumor recurrence or overall survival between control groups. contrast,...
ABO-incompatible (ABOi) dual-graft (DG) adult living donor liver transplantation (ALDLT) is not commonly performed due to its inherently intricate surgical technique and immunological complexity. Therefore, data are lacking on the short- long-term clinical outcomes of ABOi DG ALDLT. We a retrospective study by reviewing medical records patients who underwent ALDLT between 2008 2014. Additionally, computed tomography volumetric analysis was conducted assess graft regeneration rate. The mean...
Backgrounds/Aims Model for End-stage Liver Disease (MELD) score was adopted in June 2016 Korea. Methods We analyzed changes volumes and outcomes of deceased donor liver transplantation (DDLT) 1 year before after introduction MELD scoring at Asan Medical Center. Results There were 64 cases DDLT 106 introduction, an increase 65%. The volume DDLTs abruptly increased during first 3 months, but then returned to its usual level which indicated 3-month depletion accumulated recipient pool with high...
Pancreaticoduodenectomy (PD) is associated with various surgical complications including healing failure of the pancreaticojejunostomy (PJ). This study intended to ensure blood supply pancreatic stump through extended transection (EPT).This assessed whether EPT reduces PJ-associated and harmful on remnant function. The group included 19 patients undergoing PD, pylorus-preserving PD (PPPD) or hepatopancreaticoduodenectomy. propensity score matched control 45 who had undergone PPPD. Pancreatic...
Purpose: Gastroschisis and omphalocele are major anterior abdominal wall defects. The purpose of this study was to analyze the clinical differences mortalities gastroschisis in Asan Medical Center. Methods: A retrospective review medical records conducted 103 cases from September 1989 February 2013 Center Korea. Results: There were 43 (41.7%) 60 (58.3%) omphalocele. a female predominance both (60.5%) (58.3%). average gestational age at delivery 36.7±0.4 weeks for groups. mean birth weights...
Intrahepatic cholangiocarcinoma (ICC) of the left liver often shows left-sided lymph node (LN) metastasis. If gastric lesser curvature is extensively dissected, it can induce an iatrogenic injury to extragastric vagus nerve branches that control motility pyloric sphincter and lead stasis. To cope with such LN dissection-associated stasis, we performed pyloroplasty preemptively. The objective this study was analyze our 20-year experience preemptive in 10 patients.We investigated clinical...
Background: Salvage living donor liver transplantation (LDLT) is technically challenging due to adhesions caused by previous resection (LR). The purpose of this study was assess the technical feasibility LDLT after major hepatectomy and determine whether there a difference in surgical outcome according type LR received previously. Methods: We retrospectively reviewed medical records 83 patients who underwent from December 2004 June 2022, at Asan center. Results: Among patients, 74 salvage...