A5067769815- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Neurological diseases and metabolism
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- Calpain Protease Function and Regulation
- Neurological Disorders and Treatments
- Cellular transport and secretion
- Adenosine and Purinergic Signaling
- Trace Elements in Health
- Iron Metabolism and Disorders
- Conducting polymers and applications
- Cell death mechanisms and regulation
Centre National de la Recherche Scientifique
2015-2024
Sorbonne Université
2015-2024
Inserm
2015-2024
Institut du Cerveau
2015-2024
Hôpitaux Universitaires de Strasbourg
1999-2024
Université des Antilles
2019
Institut Pasteur de la Guadeloupe
2019
Institut Pasteur
2019
Université Paris Cité
2011-2018
Université de Tours
2018
To achieve accuracy in studying the patterns of loss midbrain dopamine-containing neurons Parkinson's disease, we used compartmental calbindin D28K immunostaining to subdivide substantia nigra with landmarks independent degenerative process. Within pars compacta, identified calbindin-rich regions (`matrix') and five calbindin-poor pockets (`nigrosomes') defined by analysis three-dimensional networks formed zones. These zones were recognizable all brains, despite severe neurons. The degree...
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death influenced the innate immune system. However, pathogenic role adaptive system in PD remains enigmatic. Here we showed CD8+ and CD4+ T cells but not B had invaded brain both postmortem human specimens 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model during course neuronal degeneration. We further demonstrated...
Caspase-3 is an effector of apoptosis in experimental models Parkinson's disease (PD). However, its potential role the human pathology remains to be demonstrated. Using caspase-3 immunohistochemistry on postmortem brain, we observed a positive correlation between degree neuronal loss dopaminergic (DA) cell groups affected mesencephalon PD patients and percentage caspase-3-positive neurons these control subjects significant decrease pigmented substantia nigra pars compacta compared with...
Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration dopaminergic neurons Parkinson disease (PD) that have recently been shown to die by apoptosis, but relationship between and apoptosis has not yet elucidated. Activation transcription factor NF-κB is associated with stress-induced several nonneuronal vitro models. To investigate whether it may play a role PD, we looked for translocation cytoplasm nucleus, evidence its activation, melanized...
Parkinson's disease is characterized by massive degeneration of dopamine-containing neurons in the midbrain. However, vulnerability these heterogeneous both across different midbrain cell groups and within substantia nigra, brain structure most affected this disease. To determine exact pattern loss to map cellular distribution candidate pathogenic molecules, it necessary have landmarks independent degenerative process which subdivide nigra. We developed a protocol for purpose based on...
In the brains of humans and other mammals, there are two principal groups cholinergic nuclei aside from those forming cranial motor nuclei. One group lies in forebrain includes nucleus basalis Meynert. The second hindbrain tegmenti pedunculopontinus (NPP), identified by Mesulam et al. [Mesulam, M.-M., Mufson, E. J., Wainer, B. H. & Levey, A. I. (1983) Neuroscience 10, 1185-1201] as cell Ch5. basal groups, which innervate widespread areas neocortex, undergo degeneration Alzheimer disease...
Abstract: The levels of different elements were studied by x‐ray microanalysis in the substantia nigra and central gray substance patients with Parkinson's disease, progressive supranuclear palsy, matched controls. In control brains, only iron, potassium, silicium, sodium, sulfur, zinc within limit detection technique. abundance each element was different, but their respective concentrations two brain regions similar, except for sulfur which higher on neuromelanin aggregates than nigral...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular pathways underlying its pathogenesis remain uncertain. Here, we show that eliminating c-Jun N-terminal kinases (JNKs) can prevent neurodegeneration and improve motor function in an animal model PD. First, found activated dopaminergic neurons from PD patients 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse Examination various JNK-deficient mice shows both...
Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents used treat other parkinsonian symptoms. The brain structures underlying gait falls PD aging remain be characterized. Using functional MRI healthy human subjects, we have shown here that activity of the mesencephalic locomotor region (MLR), is composed pedunculopontine nucleus (PPN) adjacent cuneiform nucleus, was modulated by speed...
Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but neurodegenerative mechanisms have not been completely elucidated. Iron accumulation dopaminergic and glial cells SN of PD patients may contribute generation oxidative stress, protein aggregation, neuronal death. The involved iron also remain unclear. Here, we describe an increase expression isoform divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) patients. Using animal model...