A5041445106- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Digital Mental Health Interventions
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Behavioral Health and Interventions
- Action Observation and Synchronization
- Mental Health and Psychiatry
- Obsessive-Compulsive Spectrum Disorders
- scientometrics and bibliometrics research
- Scientific Computing and Data Management
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Treatment and Access
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Statistical Methods in Clinical Trials
- Stress Responses and Cortisol
- Pharmaceutical industry and healthcare
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
GGZ Friesland
2015-2024
Lentis
2009-2015
Similar brain regions are involved when we imagine, observe and execute an action. Is the same true for emotions? Here, subjects were scanned while they (a) experience, (b) view someone else experiencing (c) imagine gustatory emotions (through script-driven imagery). Capitalizing on fact that disgust is repeatedly inducible within scanner environment, participants actors taste content of a cup look disgusted tasted unpleasant bitter liquids to induce disgust, read scenarios involving their...
Background International guidelines present overall symptom severity as the key dimension for clinical characterisation of major depressive disorder (MDD). However, differences may reside within levels related to how symptoms interact in an individual patient, called dynamics. Aims To investigate these by estimating proportion patients that display their dynamics while sharing same severity. Method Participants with MDD ( n = 73; mean age 34.6 years, s.d. 13.1; 56.2% female) rated baseline...
Autism Diagnostic Observation Schedule (ADOS) module 4 was investigated in an independent sample of high-functioning adult males with autism spectrum disorder (ASD) compared to three specific diagnostic groups: schizophrenia, psychopathy, and typical development. ADOS proves be a reliable instrument good predictive value. It can adequately discriminate ASD from psychopathy development, but is less respect schizophrenia due behavioral overlap between autistic negative symptoms. However, these...
One of the promises experience sampling methodology (ESM) is that a statistical analysis an individual's emotions, cognitions and behaviors in everyday-life could be used to identify relevant treatment targets. A requisite for clinical implementation outcomes such person-specific time-series analyses are not wholly contingent on researcher performing them. To evaluate this, we crowdsourced one individual patient's ESM data 12 prominent research teams, asking them what symptom(s) they would...
Abstract Background There is increasing interest in day-to-day affect fluctuations of patients with depressive and anxiety disorders. Few studies have compared repeated assessments positive (PA) negative (NA) across diagnostic groups, fluctuation patterns were not uniformly defined. The aim this study to compare a current episode or disorder, remitted controls, using instability as core concept but also describing other measures variability adjusting for possible confounders. Methods...
Although loss of pleasure (i.e., anhedonia) is one the two core symptoms depression, very little research has examined relation between depressive and experience in daily life. This exploratory study population-based adolescent samples aimed to examine how anhedonia specifically were related (1) proportion intensity positive events, (2) mean variability affect (PA), (3) reactivity (4) PA whether elicits events). We used Experience Sampling measure events several times a day during 6 14 days...
In the proposed symptom network approach to psychopathology, psychiatric disorders are assumed result from (causal) interplay between symptoms. By implementing this we explored whether individual feedback on dynamics complements current categorical classification and treatment. The aim of proof-of-principle case-study was explore feasibility, acceptability usability transdiagnostic approach.A female patient, aged 67, suffering treatment resistant anxious depressive symptoms treated in our...
Any large dataset can be analyzed in a number of ways, and it is possible that the use different analysis strategies will lead to results conclusions. One way assess whether obtained depend on strategy chosen employ multiple analysts leave each them free follow their own approach. Here, we present consensus-based guidance for conducting reporting such multi-analyst studies, discuss how broader adoption approach has potential strengthen robustness conclusions from analyses datasets basic...
The alleged association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and amygdala activation forms a cornerstone of common view that carrying short allele this polymorphism is potential risk factor for affective disorders. authors recent meta-analysis showed statistically significant (Hedges's g = 0.35) but warned estimates might be distorted because publication bias. Here, we report replication study relationship in 120 participants. We failed to find an 5-HTTLPR...
This study examined the discriminative ability of revised Autism Diagnostic Observation Schedule module 4 algorithm (Hus and Lord in J Dev Disord 44(8):1996–2012, 2014) 93 Dutch males with Spectrum Disorder (ASD), schizophrenia, psychopathy or controls. Discriminative ASD cut-off resembled original cut-off: highly specific for controls, lower sensitivity than Hus (2014; i.e. .61, AD .53). The improved over algorithm. Discriminating from schizophrenia was still challenging, but...
Depression is a leading cause of disability worldwide. To reduce the societal burden and improve quality life for individual patients, treatments depression need to be optimized. There particular person-tailored interventions that reinforce self-management patients. Systematic self-monitoring personalized feedback through Experience Sampling Method (ESM) could provide such person-tailored, empowering intervention enhances treatment outcomes. The primary aim this study investigate efficacy as...
The Experience Sampling Method (ESM) is increasingly used by researchers from various disciplines to answer novel questions about individuals’ daily lives. Measurement best practices have long been overlooked in ESM research, and recent reviews show that item quality often not reported studies. absence of information may partly be explained the lack consensus on how should evaluated. As part Item Repository project (esmitemrepository.com) — an international open science initiative collects...
Abstract Background Depression treatment might be enhanced by ecological momentary interventions (EMI) based on self-monitoring and person-specific feedback. This study is the first to examine efficacy of two different EMI modules for depression in routine clinical practice. Methods Outpatients starting at secondary mental health services ( N = 161; M IDS−DEPRESSION 35.9, s.d. 10.7; AGE 32.8, 12.1; 46% male) participated a pragmatic randomized controlled trial with three arms. Two...
Experts in clinical mental health research count on personalized approaches based self-monitoring and self-management to improve treatment efficacy psychiatry. Among other things, researchers expect that Ecological Momentary Interventions (EMI) feedback will reduce depressive symptoms. Clinical trial findings have, however, been conflicting. A recent (ZELF-i) investigated whether depression might be enhanced by an add-on EMI with items focused positive affect activities (Do-module) or...
The Experience Sampling Method (ESM) is increasingly used by researchers from various disciplines to answer novel questions about individuals’ daily lives. Measurement best practices have long been overlooked in ESM research, and recent reviews show that item quality often not reported studies. absence of information may partly be explained the lack consensus on how should evaluated. As part Item Repository project (esmitemrepository.com) — an international open science initiative collects...
The Experience Sampling Method (ESM) is increasingly used by researchers from various disciplines to answer novel questions about individuals’ daily lives. Measurement best practices have long been overlooked in ESM research, and recent reviews show that item quality often not reported studies. absence of information may partly be explained the lack consensus on how should evaluated. As part Item Repository project (esmitemrepository.com) — an international open science initiative collects...