A5100645089- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bacterial Infections and Vaccines
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Pneumonia and Respiratory Infections
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- IL-33, ST2, and ILC Pathways
- PI3K/AKT/mTOR signaling in cancer
- S100 Proteins and Annexins
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
- Chromatin Remodeling and Cancer
- Microbial infections and disease research
- Cancer, Hypoxia, and Metabolism
Sun Yat-sen University
2020-2023
NewGen Therapeutics (United States)
2023
The University of Texas MD Anderson Cancer Center
2011-2022
Tianjin Institute of Pharmaceutical Research (China)
2018
Boston University
2008-2016
TherapeuticsMD (United States)
2011-2015
Huazhong University of Science and Technology
2007-2015
Hangzhou Hospital of Traditional Chinese Medicine
2015
Boston Medical Center
2010-2013
University of Wrocław
2011
Most solid tumors and their metastases experience periods of low oxygen or hypoxia, which is major clinical significance as it promotes both tumor progression resistance to therapy. Critical mediators the hypoxic response are hypoxia-inducible factors HIF-1α HIF-2α. The HIFs nonredundant regulate overlapping unique downstream target genes. Here, we describe a novel mechanism for switch between HIF-1α- HIF-2α-dependent transcription during hypoxia caused by associated factor (HAF). HAF...
Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have identified important somatic mutations in endometrial cancer, they primarily focused on a small set of known genes and thus provided limited view molecular basis underlying this disease. Here we developed an integrated systems-biology approach to identifying novel contributing tumorigenesis. We first performed whole-exome sequencing 13...
Abstract Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response most cases presses question how general can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by vivo passaging Kras-mutated, p53-deficient murine cancer cells (p53R172HΔg/+K-rasLA1/+) syngeneic host exposed repetitive dosing anti-mouse PD-1 antibodies. PD-L1 (CD274) expression did not differ...
Commensal flora plays important roles in the regulation of gene expression involved many intestinal functions and maintenance immune homeostasis, as well pathogenesis inflammatory bowel diseases. The microRNAs (miRNAs), a class small, noncoding RNAs, act key regulators biological processes. miRNAs are highly conserved among species appear to play both innate adaptive immunity, they can control differentiation various cells, their functions. However, it is still largely unknown how microbiota...
Epigenetic changes are associated with the regulation of transcription key cell regulatory genes [micro RNAs (miRNAs)] during different types liver injury. This study evaluated role methylation-associated miRNA, miR-34a, in alcoholic diseases. We identified that ethanol feeding for 4 weeks significantly up-regulated 0.8% known miRNA compared controls, including miR-34a. Treatment normal human hepatocytes (N-Heps) and cholangiocytes [human intrahepatic biliary epithelial cells (HiBECs)]...
<h3>Background</h3> Worldwide, gastric cancer (GC) is the fourth most common malignancy and in East Asia. Development of targeted therapies for this disease has focused on a few known oncogenes but had limited effects. <h3>Objective</h3> To determine oncogenic mechanisms novel therapeutic targets specific GC by identifying commonly dysregulated genes from tumours both Asian-Pacific Caucasian patients. <h3>Methods</h3> We generated transcriptomic profiles 22 their matched non-cancerous...
1,25-Dihydroxyvitamin D(3) (1,25D) used to treat human acute myeloid leukemia (AML) cells induces features of normal monocytes, but the mechanisms underlying this response are not fully understood. We hypothesized that one or more microRNAs (miRNA) known control mouse hematopoiesis and lineage commitment might contribute ability 1,25D malignant phenotype. Here we report markedly expression miR-32 in cells, which it targets 3'-untranslated region mRNA encoding proapoptotic factor Bim reduce...
IL-6/Stat3 is associated with the regulation of transcription key cellular regulatory genes (microRNAs) during different types liver injury. This study evaluated role in regulating miRNA and miR-21 alcoholic disease. By microarray, we identified that ethanol feeding significantly up-regulated 0.8% known microRNAs mouse compared controls, including miR-21. Similarly, treatment normal human hepatocytes (N-Heps) hepatic stellate cells (HSCs) IL-6 increased expression. Overexpression decreased...
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with poor outcomes conventional therapy. Nearly 100% of BPDCNs overexpress interleukin 3 receptor subunit alpha (CD123). Given that CD123 differentially expressed on the surface BPDCN cells, it has emerged as an attractive therapeutic target. UCART123 investigational product consisting allogeneic T cells expressing anti-CD123 chimeric antigen (CAR), edited TALEN ® nucleases. In this study, we...
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to lack insight into deep mechanistic processes. In the past decade, deciphering functions small noncoding miRNAs in sepsis pathogenesis became dynamic research topic. To screen new miRNA targets therapeutics, we used samples array analysis PBMCs from patients with control individuals, blood 2 cohorts sepsis, multiple animal models: mouse cecum ligation...
Macrophages clear apoptotic cells through a process called continual efferocytosis. We found that protocatechuic acid (PCA), polyphenolic compound abundant in fruits and vegetables, increased the efferocytic capacity of macrophages inhibited progression advanced atherosclerosis. PCA reduced intracellular amounts microRNA-10b (miR-10b) by promoting its secretion extracellular vesicles, which led to an increase abundance miR-10b target Krüppel-like factor 4 (KLF4). In turn, KLF4...
Malignant peripheral nerve sheath tumours (MPNSTs), which develop sporadically or from neurofibromatosis, recur frequently with high metastatic potential and poor outcome. The polycomb group protein enhancer of zeste homologue 2 (EZH2) is an important regulator for various human malignancies. However, the function EZH2 in MPNSTs unknown. Here we report that EZH2-miR-30d-KPNB1 signalling pathway critical MPNST tumour cell survival vitro tumourigenicity vivo. Up-regulated inhibits miR-30d...
Commensal flora plays an important role in the development of mucosal immune system and maintaining intestinal homeostasis. However, mechanisms involved regulation host‐microbiota interaction are still not completely understood. In this study, we examined how microbiota inflammatory conditions regulate host micro RNA expression observed lower ‐107 (mi R ‐107) inflamed intestines colitic mice, compared with that normal control mice. mi was predominantly reduced epithelial cells CD 11c +...
Abstract Abnormal tau hyperphosphorylation is an early pathological marker of Alzheimer’s disease (AD), however, the upstream factors that regulate phosphorylation are not illustrated and there no efficient strategy to arrest hyperphosphorylation. Here, we find activation endogenous EphB2 receptor by ligand stimulation (ephrinB1/Fc) or ectopic expression plus induces a remarkable dephosphorylation at multiple AD-associated sites in SK-N-SH cells human embryonic kidney stably express...
Neutrophils are the first responders to sites of inflammation when intestinal epithelial barrier is breached and gut microbiota invade. Despite current efforts in understanding role neutrophils homeostasis, complex interactions between cells (IECs) still not well characterized. In this study, we demonstrated that enhanced production amphiregulin (AREG), a member EGFR ligand family, by IECs, which promoted IEC function tissue repair. Depletion resulted more severe colitis mice because...
Inducible nitric-oxide (NO) synthase (iNOS) plays a critical role in the eradication of intracellular pathogens. However, excessive production NO by iNOS has also been implicated pathogenesis septic shock syndrome. Previously, we have demonstrated that mice deficient mitogen-activated protein kinase phosphatase-1 (MKP-1) exhibit exaggerated inflammatory responses and rapidly succumb to lipopolysaccharide (LPS). In response LPS, MKP-1−/− produce greater amounts cytokines than do wild-type...
ABSTRACT Many bacterial components selectively activate immune and nonhematopoietic target cells via Toll-like receptor (TLR) signaling; modulation of such host responses defines the adjuvant properties these products. For example, outer membrane protein porins from Neisseria , Salmonella Shigella are known TLR2 agonists with established systemic mucosal adjuvanticity. Early work indicated that FomA porin Fusobacterium nucleatum has activity in mice. Using a purified recombinant FomA, we...
The tumor-suppressive activity of FOXP3 has been observed in tumor initiation, but the underlying mechanism still remains largely unknown. Here, we identified a FOXP3-microRNA-146 (miR-146)-NF-κB axis vitro and vivo prostate cancer cells. We that dramatically induced expression miR-146a/b, which contributed to transcriptional inhibition IRAK1 TRAF6, cell lines. Tissue-specific deletion Foxp3 mouse caused significant reduction miR-146a upregulation NF-κB activation. In addition, prostatic...
The hypoxia‐inducible factor (HIF), HIF‐1, is a central regulator of the response to low oxygen or inflammatory stress and plays an essential role in survival function immune cells. However, mechanisms regulating nonhypoxic induction HIF‐1 remain unclear. Here, we assess impact germline heterozygosity novel, oxygen‐independent ubiquitin ligase for HIF‐1α: hypoxia‐associated (HAF; encoded by SART1 ). SART1−/− mice were embryonic lethal, whereas male SART1+/− spontaneously recapitulated key...