A5060975734- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Polyamine Metabolism and Applications
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Plant Micronutrient Interactions and Effects
- Circadian rhythm and melatonin
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Fungal and yeast genetics research
- Magnesium in Health and Disease
- Gene Regulatory Network Analysis
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
Ludwig-Maximilians-Universität München
2015-2020
Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum of neurodegenerative disorders, including Parkinson's disease (PD). We recently revealed that the late endo-lysosomal transporter pumps polyamines like spermine into cytosol, whereas dysfunction causes lysosomal polyamine accumulation and rupture. Here, we investigate how provides protection against mitochondrial toxins such as rotenone, an environmental PD risk factor. Rotenone promoted...
P5B ATPases are present in the genomes of diverse unicellular and multicellular eukaryotes, indicating that they have an ancient origin, important for cellular fitness. Inactivation ATP13A2, one four human ATPases, leads to early-onset Parkinson’s disease (Kufor-Rakeb Syndrome). The presence invariant PPALP motif within putative substrate interaction pocket transmembrane segment M4 suggests all might similar transport specificity; however, identity substrate(s) remains unknown. Nematodes...
TRP (Transient Receptor Potential) cation channels of the TRPM subfamily have been found to be critically important for regulation Mg2+ homeostasis in both protostomes (e.g., nematode, C. elegans, and insect, D. melanogaster) deuterostomes humans). Although significant progress has made toward understanding how activities these are regulated, there still major gaps our potential regulatory roles extensive, evolutionarily conserved, regions proteins. The elegans genes, gon-2, gtl-1 gtl-2,...