A5037234666- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Dementia and Cognitive Impairment Research
- Thyroid Disorders and Treatments
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- COVID-19 and Mental Health
- Mindfulness and Compassion Interventions
- Anesthesia and Neurotoxicity Research
- Lipoproteins and Cardiovascular Health
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Mental Health Research Topics
- Fatty Acid Research and Health
- Neurobiology of Language and Bilingualism
- Sphingolipid Metabolism and Signaling
National University of Distance Education
2016-2025
Instituto de Salud Carlos III
2025
University of Kufa
2024
Valencian International University
2024
University of Kentucky
2024
Temple College
2024
Temple University
2024
Hurley Medical Center
2024
University of Iowa Hospitals and Clinics
2024
Al-Quds University
2024
Abstract Glucocorticoids can rapidly affect neuronal function and behaviour in mammals. Several studies have suggested the possible existence of rapid, non‐genomic effects glucocorticoids hippocampus. To investigate whether could neurotransmission hippocampus through mechanisms, we studied acute glucocorticoid administration on extracellular amino acid levels CA1 area By means microdialysis freely moving rats, observed that an intraperitoneal injection corticosterone (2.5 mg/kg) induced a...
The transcriptional properties of unliganded thyroid hormone receptors are thought to cause the misdevelopment during hypothyroidism several functions essential for adult life. To specifically determine role receptor α1 (TRα1) in neuronal tissues, we introduced a mutation into mouse TRα1 gene that lowers affinity (TH) 10-fold. resulting heterozygous mice exhibit distinct neurological abnormalities: extreme anxiety, reduced recognition memory, and locomotor dysfunction. anxiety memory...
Glucocorticoids modulate brain function and behaviour through different mechanisms. Although classical effects are mediated intracellular receptors that gene transcription, recent evidence supports the existence of rapid, nongenomic steroid neuronal membrane. In this study, we explored possible rapid behavioural corticosterone in rat, which could provide a model to characterize further mechanisms involved corticosteroid actions. We found injection, at doses (2.5 or 5 mg/kg) mimic plasma...
Emotionally charged experiences alter memory storage via the activation of hormonal systems. Previously, we have shown that compared with rats trained for a massed spatial learning task in water maze warm (25°C), animals were cold (19°C) performed better and showed higher levels stress hormone corticosterone. Here, examined whether manipulating corticosterone can determine strength information acquisition retention. Rats injected metyrapone (25, 50, 75 mg/kg, i.p.) or (10 25 either (25°C)...
The neural cell adhesion molecule (NCAM) plays a critical role in development and plasticity of the nervous system is involved mechanisms learning memory. Here, we show that intracerebroventricular administration FG loop (FGL), synthetic 15 amino acid peptide corresponding to binding site NCAM for fibroblast growth factor receptor 1 (FGFR1), immediately after training rats fear conditioning or water maze learning, induced long-lasting improvement In primary cultures hippocampal neurons, FGL...
Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common effects in this statin-intolerant population.To determine the effect and tolerance of EOD rosuvastatin previously intolerant therapy.We performed retrospective analysis treated with at 2 lipid specialty clinics: University Kansas Lipid, Atherosclerosis, LDL-Apheresis...
Article7 December 2018Open Access Source DataTransparent process Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in storage disorders Enrique Gabandé-Rodríguez Corresponding Author [email protected] Department of Molecular Neuropathology, Centro de Biología "Severo Ochoa" (CSIC-UAM), Madrid, Spain Barts Cancer Institute, Centre for & Inflammation, Queen Mary University London, UK Search more papers by this author Azucena Pérez-Cañamás Beatriz...
Cognitive capacities decline with age, an event accompanied by the altered transcription of synaptic plasticity genes. Here, we show that transcriptional induction Bdnf a mnemonic stimulus is impaired in aged hippocampal neurons. Mechanistically, this defect due to reduced NMDA receptor (NMDAR)-mediated activation CaMKII. Decreased NMDAR signaling prevents changes associated at specific promoters, including displacement histone deacetylase 4, recruitment acetyltransferase CBP, increased...
Abstract Memory formation has been associated with structural and functional modifications of synapses. Cell adhesion molecules are prominent modulators synaptic plasticity. Here, we investigated the involvement cell molecules, NCAM, its polysialylated state (PSA‐NCAM) L1 in spatial learning‐induced remodeling memory storage. A differential regulation these was found hippocampus rats submitted to one training session spatial, but not cued, version Morris water maze. Twenty‐four hours after...
The role of the hippocampus in pavlovian fear conditioning is controversial. Although lesion and pharmacological inactivation studies have suggested a key for dorsal contextual conditioning, involvement ventral part still uncertain. Likewise, debate open with regard to putative implication each hippocampal subdivision discrete conditioned stimulus. We explored potential existence dissociations occurring versus at cellular level while dealing either or cued focused molecular “signature”...
As the conceptual, methodological, and technological advances applied to dementias have evolved construct of mild cognitive impairment (MCI), one problem encountered has been its classification into subtypes. Here, we aim revise concept MCI subtypes, addressing problems not only from psychometric point view or by using alternative methods, such as latent class analysis, but also considering absence normative data. In addition well-known influence certain factors on function, educational...
Aging is associated with a decline in cognitive abilities, mainly memory and executive functioning. A similar but premature deterioration capacities the hallmark of mild impairment, Alzeimer's disease dementia. The biochemical mechanisms that cause these neurodegenerative disorders are poorly understood. However, some evidence suggests insufficient dietary intakes phospholipids could impact on brain function increase risk future impairment We evaluated effects supplementation milk fat...