To investigate the potential of optical coherence tomography (OCT) measurement retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) area photopic negative response (PhNR) for predicting postoperative visual outcome in chiasmal compression, prospectively.Eighteen eyes 18 patients undergoing decompression surgery were prospectively assessed before, 3 months after with standard automated perimetry (SAP), OCT, PhNR. Preoperative measurements compared 20 age-matched...

Purpose.: To investigate the time course of visual field recovery and changes retinal ganglion cells (RGCs) after chiasmal decompression using standard automated perimetry (SAP), optical coherence tomography (OCT), photopic negative response (PhNR). Methods.: Nineteen patients undergoing surgery were prospectively assessed before 1 3 months surgery. The same examinations conducted in nine at 6 Mean deviation temporal sensitivity (1/Lambert) SAP, nerve fiber layer (RNFL) thickness, cell...

Laser photocoagulation is a well-established treatment modality for retinal disease. Discrete laser burns can be placed anywhere in the retina, singly or multiply, and burn intensity controllable. This study investigates effect of prior on transduction properties intravitreally administered adeno-associated viral (AAV) vectors. C57BL/6J mice were subjected to unilateral 48 hr before bilateral intravitreal injection self-complementary cytomegaloviral enhanced green fluorescent protein (EGFP)...

Purpose.: To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate association between functional structural after selective retina therapy (SRT) microsecond-pulsed laser in comparison to continuous wave photocoagulation (cwPC). Methods.: Selective cwPC were applied 10 × shots 1/2 lesion-width on right left eyes 20 healthy Chinchilla Bastard rabbits, respectively. Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), mfERG...

To determine the clinical utility of using photopic negative response (PhNR) by comparing parameters for normal, primary open angle glaucoma (POAG) and diabetic retinopathy (DR).Electroretinography (UTAS E-3000) was performed in 12 POAG, DR subjects. Amplitudes implicit times PhNR were compared among three groups. The mean deviation (MD) pattern standard (PSD) evaluated automated perimetry (SAP). retinal nerve fiber layer (RNFL) thickness cup-disc ratio measured optical coherence...

To report on the anatomical and functional changes to macula in nine patients suffering from commotio retinae not accompanied by any other types of traumatic retinopathy.Nine injured eyes with were evaluated soon after ocular trauma ophthalmic examination, including Spectral-domain optical coherence tomography (SD-OCT). In 12 6 patients, Humphrey visual field (HVF) multifocal electroretinogram (mfERG) performed. Re-examinations periodically performed for a mean 26 days. Data 9 collected...

We investigated the case of a young man with blurred vision in his left eye.His visual acuity was slightly decreased, and ophthalmoscopy disclosed gray-white lesion macula.He had no systemic or ocular history.On field test, threshold sensitivity decreased corresponding region.Spectral domain optical coherence tomography (OCT) demonstrated disruption photoreceptor inner outer segment (IS/OS) junction undulation retinal pigment epithelium (RPE) backscattering.We re-examined patient after two...

To investigate the characteristics of retinal pigment epithelium (RPE) and damage induced by selective retina therapy (SRT) in mice, to elucidate longitudinal changes RPE cells.C57BL/6J mice received SRT continuous-wave laser photocoagulation (cwPC). The cell death pattern was evaluated using TUNEL assay, proliferative potential cells 5-ethynyl-2'-dexoyuridine (EdU) assay. cell-cell integrity cells, β-catenin staining performed. number hexagonality SRT-treated area were estimated a Voronoi...

Purpose.: The purpose of the study was to investigate diagnostic ability neurologic hemifield test (NHT) and retinal nerve fiber layer (RNFL) thickness measurements detect chiasmal compression. Methods.: Thirty-seven patients with compression, 35 glaucoma, 30 glaucoma suspect were enrolled. NHT score established from a 30-2 visual field pattern deviation probability plot. Each point value calculated for number that inversely proportional its probability. absolute difference in sum scores two...

We compared the best-corrected Snellen acuity (SA) and pattern reversal visual-evoked response (PVER) in normal subjects patients. Forty-two eyes of 42 were controls; 457 329 patients comprised patient group. A steady-state stimulus with five check sizes ranging from 160 to 10 min 1.0-octave steps was used. The PVER derived best-fit linear function relating amplitude log-adjusted size. Three intercepts 0, 1 2 μV used both groups, acuities called P°, P1 P2. SAs ranged 20/15 20/20 (mean,...

This study investigated the time course of cell proliferation after laser photocoagulation and analyzed types proliferating cells.C57BL/6J mice received unilateral photocoagulation. Intraperitoneal bromodeoxyuridine (BrdU) injection was performed, were divided into two groups according to paradigm: group 1 with continuous 2 periodic injection. Each again four subgroups period: 0 3 days (n = 11), 7 14), 14 6), 28 6) for 1; 4 8 15 2. The eyes examined immunohistochemistry using anti-BrdU...

Purpose: To evaluate the changes in multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) after intravitreal bevacizumab injection treatment of age-related macular degeneration (AMD).Methods: Twenty-one eyes with choroidal neovascularization secondary to AMD were studied before for best corrected visual acuity (BCVA), OCT, mfERG.Results: The BCVA improved, while central thickness total volume OCT decreased (p = 0.03, 0.01, respectively).In mfERG, amplitude P1, implicit...

To investigate the effects of high glucose levels and anti-vascular endothelial growth factor (VEGF) agents (bevacizumab, ranibizumab aflibercept) on retinal pigment epithelium (RPE) cells.ARPE-19 cells were cultured at different (5.5 mmol/L, 25 75 mmol/L). Cell viability was evaluated by MTT assay 3d after treatment with D-glucose. migration ability measured wound healing 3d. A cell death detection kit used to assess apoptosis 3 14d. proliferation assessed EdU The culture medium treated...

당뇨망막병증 진행의 평가를 위한 망막전위도의 유용성순천향대학교 의과대학 안과학교실 2 목적: 당뇨망막병증의 진행에 따른 망막전위도 변화와 명음성반응을 포함한 여러 파형들의 임상적 중요성을 알아보고자 하였다.대상과 방법: 당뇨환자 143명과 정상인 28명을 대상으로 표준망막전위도를 시행하였다.암순응하 반응으로 진동소파전위, 최대복합반 응 b-

To introduce the clinical utility of absolute value reconstructed waveform method in analysis multifocal visual evoked potential (mfVEP).The mfVEP with 4-channel recording was performed using RETIscan® on 10 eyes normal subjects. Amplitudes were obtained from ring-shaped 6 areas and 4 sectors. The best (VEP) response compared terms amplitudes. In order to assess false positive rate examination, stimuli administered one-half cathode ray tube (CRT) monitor completely covered results 2...

To investigate the characteristics of waveform generated by blue and red light stimulations in a dark-adapted electroretinogram (ERG) those cone responses condition.The study subjects were 52 persons (88 eyes) with no previous medical history. The author recorded b-waves (rod response) stimulation x-waves (dark-adapted that appeared before b-waves. also stimulation, which had same amplitude as from stimulation. differences respect to age gender studied. Waveforms ERGs using digital...