A5100390959- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Advanced Vision and Imaging
- T-cell and B-cell Immunology
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- 3D Shape Modeling and Analysis
- Quantum Mechanics and Applications
- Protease and Inhibitor Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Prenatal Screening and Diagnostics
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Aquaculture Nutrition and Growth
- Glycosylation and Glycoproteins Research
- Computer Graphics and Visualization Techniques
- Monoclonal and Polyclonal Antibodies Research
- Hearing, Cochlea, Tinnitus, Genetics
University of Hong Kong
2013-2025
Harvard University
2021-2025
Hong Kong University of Science and Technology
2025
Brigham and Women's Hospital
2021-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Kunming Medical University
2024
Guangdong Province Women and Children Hospital
2019-2024
Shanghai Jiao Tong University
2019-2024
We present a novel neural surface reconstruction method, called NeuS, for reconstructing objects and scenes with high fidelity from 2D image inputs. Existing approaches, such as DVR IDR, require foreground mask supervision, easily get trapped in local minima, therefore struggle the of severe self-occlusion or thin structures. Meanwhile, recent methods view synthesis, NeRF its variants, use volume rendering to produce scene representation robustness optimization, even highly complex objects....
This paper presents a novel grid-based NeRF called F <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> - (Fast-Free-NeRF) for view synthesis, which enables arbitrary input camera trajectories and only costs few minutes training. Existing fast training frameworks, like Instant-NGP, Plenoxels, DVGO, or TensoRF, are mainly designed bounded scenes rely on space warping to handle unbounded scenes. two widely-used space-warping methods the...
The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion molecule (ICAM)-1 play an important role in transmigration as demonstrated by vivo vitro models of inflammation. Despite the prominent role, little is known concerning distribution dynamic behavior these molecules during transmigration. Therefore, we examined spatial temporal LFA-1 on neutrophils actively transmigrating tumor necrosis factor-α–activated human umbilical...
Abstract Aims Recent evidence suggests that ‘vulnerable plaques’, which have received intense attention as underlying mechanism of acute coronary syndromes over the decades, actually rarely rupture and cause clinical events. Superficial plaque erosion has emerged a growing residual thrombotic complications atherosclerosis in an era increased preventive measures including lipid lowering, antihypertensive therapy, smoking cessation. The mechanisms remain poorly understood, we currently lack...
We present a novel method, called NeuralUDF, for reconstructing surfaces with arbitrary topologies from 2D images via volume rendering. Recent advances in neural rendering based reconstruction have achieved compelling results. However, these methods are limited to objects closed since they adopt Signed Distance Function (SDF) as surface representation which requires the target shape be divided into inside and outside. In this paper, we propose represent Unsigned (UDF) develop new scheme...
Neutrophil (PMN) transepithelial migration is dependent on the leukocyte beta(2) integrin CD11b/CD18, yet identity of epithelial counterreceptors remain elusive. Recently, a JAM protein family member termed JAM-C was implicated in adhesive interactions; however, its expression epithelia and role PMN-epithelial interactions are unknown. Here, we demonstrate that abundantly expressed basolaterally intestinal localizes to desmosomes but not tight junctions. Desmosomal localization further...
Novel monomethylauristatin E (MMAE) prodrug 8 was designed and prepared that bound cell surface glycoprotein integrin αvβ3, activated using legumain protease as a catalyst. Upon activation, strongly induced the death of MDA-MB-435 cells express αvβ3 on surface. Efficacies were also determined in vivo animal models 4T1 murine breast cancer, D121 Lewis lung carcinoma, human cancer. The results demonstrated decreased tumor growth metastasis effectively. In comparison to parent cytotoxin, MMAE,...
CD8 hi regulatory T cells control graft-versus-host disease without inhibiting graft versus tumor or general immunity in humanized mice.
Elucidating the temporal process of immune remodeling under immunosuppressive treatment after liver transplantation (LT) is critical for precise clinical management strategies. Here, we performed a single-cell multi-omics analysis peripheral blood mononuclear cells (PBMCs) collected from LT patients (with and without acute cellular rejection [ACR]) at 13 time points. Validation was in two independent cohorts with additional healthy controls. Our study revealed four-phase recovery delineated...
Despite advances in the clinical management of HIV infection, using combinations antiretroviral pharmaceuticals, a safe and efficacious vaccine is needed to limit AIDS pandemic. It now thought that an effective HIV-1 should prime both cross-neutralizing antibodies long-lasting cytotoxic CD8+ T lymphocytes (CTLs) recognizing multiple codominant epitopes. To end, many novel strategies have been tested. However, only few these strategies, beside those relying on live-attenuated viruses, are...
Hepatitis B virus (HBV) is closely related to occurrence and development of viral hepatitis. A mutation 1896nt locus in its pre-C region can promote replication HBV DNA improve stability pre-genome RNA structure, even help evade immune clearance. In this study, magnetic beads-probe (MBs@probe) method, combined with single base extension (SBE) technology, was developed for in-situ detection locus. Before successfully completing the genotyping 165 samples, crucial reaction conditions were...
Cytokine-induced killer (CIK) cells that are stimulated using mature dendritic (DCs), referred to as (DC-CIK cells) exhibit superior anti-tumor potency. Anti-programmed death-1 (PD-1) antibodies reinvigorate T cell-mediated antitumor immunity. This phase I study aimed assess the safety and clinical activity of immunotherapy with PD-1 blockade (pembrolizumab)-activated autologous DC-CIK in patients advanced solid tumors. Patients selected types tumors received a single intravenous infusion...
In this paper, we present a new method for the multi-view registration of point cloud. Previous multiview methods rely on exhaustive pairwise to construct densely-connected pose graph and apply Iteratively Reweighted Least Square (IRLS) compute scan poses. However, constructing is time-consuming contains lots outlier edges, which makes subsequent IRLS struggle find correct To address above problems, first propose use neural network estimate overlap between pairs, enables us sparse but...
Obesity, in which the functional importance of small nucleolar RNAs (snoRNAs) remains elusive, correlates with risk for many cancer types. Here, we identify that serum copies adipocyte-expressed SNORD46 correlate body mass index (BMI), and antagonizes interleukin-15 (IL-15) signaling. Mechanically, binds IL-15 via G11, G11A (a mutation significantly enhances binding affinity) knockin drives obesity mice. Functionally, blocks IL-15-induced, FER kinase-dependent phosphorylation platelet...
Obesity is associated with chronic low-level inflammation, especially in fat tissues, which contributes to insulin resistance and type 2 diabetes mellitus (T2DM). Protein inhibitor of activated STAT 1 (PIAS1) modulates a variety cellular processes such as cell proliferation DNA damage responses. Particularly, PIAS1 functions the innate immune system key regulator inflammation cascade. However, whether involved regulation sensitivity remains unknown. Here, we demonstrated that expression...
We show that a quantum correlation <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"><a:mi>p</a:mi></a:math> is in face of the nonsignaling polytope with no local points if and only <b:math xmlns:b="http://www.w3.org/1998/Math/MathML"><b:mi>p</b:mi></b:math> has nonlocal content 1, <c:math xmlns:c="http://www.w3.org/1998/Math/MathML"><c:mi>p</c:mi></c:math> allows for Greenberger-Horne-Zeilinger-like proof, <d:math xmlns:d="http://www.w3.org/1998/Math/MathML"><d:mi>p</d:mi></d:math>...
The β2 integrin CD11b/CD18 is an integral membrane protein that present in the plasma and secondary granules of neutrophils functions as a major adhesion molecule. Upon cellular activation, there translocation intracellular pools to concert with enhanced adhesion. Although much known about function CD11b/CD18, how this transported within cell less well defined. Here we report specifically binds BAP31, member novel class sorting proteins regulating anterograde transport. Through experiments...
Objective: Limited large sample studies have specially compared overall and abdominal obesity in relation to central arterial stiffness hemodynamics community-dwelling adults, especially the People's Republic of China. This study aimed compare relationship between an indicator (body mass index [BMI]), (waist circumference [WC]), hemodynamics, independent age, sex, blood pressure, glucose, lipids, Chinese adults. Methods: For 2,624 adults this study, anthropometric indices, such as BMI WC,...