A5001025590- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Statistical Methods in Clinical Trials
- Infant Nutrition and Health
- Influenza Virus Research Studies
- Body Composition Measurement Techniques
- COVID-19 Clinical Research Studies
- Thermoregulation and physiological responses
- Breastfeeding Practices and Influences
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- Hepatitis B Virus Studies
- Sepsis Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- COVID-19 epidemiological studies
- Nutrition and Health in Aging
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Bayesian Modeling and Causal Inference
- Meta-analysis and systematic reviews
- vaccines and immunoinformatics approaches
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Heparin-Induced Thrombocytopenia and Thrombosis
The Kids Research Institute Australia
2021-2025
The University of Western Australia
2020-2025
Princess Margaret Hospital for Children
2024-2025
Objective To assess the short term safety of COVID-19 vaccines Comirnaty (Pfizer–BioNTech BNT162b2) and Vaxzevria (AstraZeneca ChAdOx1) in Australia. Design Prospective observational cohort study; online surveys by AusVaxSafety, a national active vaccine surveillance system, three eight days after vaccination. Setting, participants People aged 16 years or more who received at sentinel vaccination hubs, general practices, Aboriginal Community Controlled Health Organisation clinics, 22...
The Platform trial In COVID-19 priming and BOOsting (PICOBOO) is a multi-site, adaptive platform designed to generate evidence of the immunogenicity, reactogenicity, cross-protection different booster vaccination strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) its variants, specific for Australian context. PICOBOO randomises participants receive one three vaccine brands (Pfizer, Moderna, Novavax) available use in Australia, where brand subtypes vary over time...
Abstract Background The need for coronavirus 2019 (COVID-19) vaccination in different age groups and populations is a subject of great uncertainty an ongoing global debate. Critical knowledge gaps regarding COVID-19 include the duration protection offered by priming booster regimens populations, including homologous or heterologous schedules; how impacts key elements immune system; this modified prior subsequent exposure to severe acute respiratory syndrome 2 (SARS-CoV-2) future variants;...
Abstract Background PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. Here, we report data for second boosters among individuals aged 18-< 50 50-< 70 years old primed with BNT162b2 (18-< 50y-BNT162b2 70y-BNT162b2, respectively) until Day (D) 84. CONSORT diagram participants recruited to 18-<50y-BNT162b2 (A) 50-<70y-BNT162b2 (B) strata vaccines. Participants were excluded from...
Abstract Background PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. Here, we report data for second boosters among individuals aged 50-< 70 years old primed with AZD1222 (50-< 70y-AZD1222) until Day (D) 84. CONSORT diagram participants recruited to 50-<70y-AZD1222 stratum vaccines. Participants were excluded from subsequent analyses if they infected (C19 Infection) or had withdrawn. that...
Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, Staphylococcus aureus Network Adaptive (SNAP) trial to provide an informal template other researchers reviewers platform trials. briefly content role core protocol, appendix, domain-specific appendices, simulation report, implementation...
Policy and clinical practice guidelines are dependent on high quality evidence when making vaccine recommendations. A review of the used to inform could help guide researchers how improve design their studies produce greater value decision-makers. In Australia, Australian Technical Advisory Group Immunisation (ATAGI) develops evidence-based recommendations using Grading Recommendations Assessment, Development Evaluation (GRADE) methodology, a transparent, systematic methodical framework for...
<title>Abstract</title> <bold>Background</bold> The demand for adaptive trial designs is growing because of their flexibility and the potential efficiency gains over traditional fixed designs. Adaptive trials allow planned modifications to design based on accumulating data. Simulation imperative in designing analytical power formulae cannot account data driven adaptations. Despite popularity, uptake has been slowed by lack expertise availability training resources.<bold>Methods</bold> In...
Maternal diet has the potential to affect human milk (HM) composition, but very few studies have directly assessed effect of maternal diets on HM composition. The primary aim this study was assess improving dietary quality in lactating women over 2 weeks concentrations macronutrients and metabolic hormones HM. secondary aims were impact intervention 24 h production, body composition infant growth. Fifteen completed a 1-week baseline period followed by 2-week phase targeted towards reducing...
A limited number of studies have assessed the accuracy and precision methods for determining net endogenous acid production (NEAP) its components. We aimed to investigate performance quantifying diet dependent acid-base load.Data from metabolic balance enabled calculations NEAP according biochemical measures (of excretion [NAE], urinary [UNEAP], potential renal load [UPRAL]) as well estimative equations (by Frassetto et al., Remer Manz, Sebastian Lemann) that were compared among themselves...
Abstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform that aims to improve the way S. bloodstream infection, globally common and severe infectious disease, treated. In world first, SNAP will simultaneously investigate effects of multiple intervention modalities within groups participants with different forms infection. Here, we formalise structure, modelling approach, decision rules be used for trial. By summarising...
Pneumonia remains a leading cause of hospitalization and death among young children worldwide, the diagnostic challenge differentiating bacterial from non-bacterial pneumonia is main driver antibiotic use for treating in children. Causal Bayesian networks (BNs) serve as powerful tools this problem they provide clear maps probabilistic relationships between variables produce results an explainable way by incorporating both domain expert knowledge numerical data.We used data combination...
Abstract Analysis of the human milk microbiome is complicated by presence a variable quantity fat. The fat fraction typically discarded prior to analysis. It assumed that all cells are pelleted out high speed centrifugation; however, studies bovine have reported bacteria may remain trapped within fraction. Here, bacterial DNA profiles and cell pellet (n = 10) were analysed. Human was consistently recovered from (average 12.4% 32.7%, respectively). Two low-abundance Staphylococcus species...
Abstract Human milk (HM) composition is known to be highly variable, both between individuals and across the duration of lactation. It less clear, however, what extent fat, lactose protein concentrations in HM change daily over shorter time periods mature HM, no studies have evaluated this date. The aim study was systematically assess compare macronutrient samples collected at different times day, from left right breasts a 3-week period same woman. Fifteen lactating women (1.6–4.9 months...
The early detection of adverse events following immunisation (AEFI) is essential to protect public health and maintain confidence in vaccination. Vaccine pharmacovigilance — the monitoring, detection, investigation actioning vaccine safety signals occurs across a collaborative landscape that includes Therapeutic Goods Administration (TGA), nationally funded surveillance initiative AusVaxSafety, state territory departments. purpose these systems monitor for unexpected types rates AEFI,...
Abstract Background Immunocompromised hosts (ICH) experience more breakthrough infections and worse clinical outcomes following infection with COVID-19 than immunocompetent people. Prophylactic monoclonal antibody therapies can be challenging to access, escape variants emerge rapidly. Immunity conferred through vaccination remains a central prevention strategy for COVID-19. vaccines do not elicit optimal immunity in ICH but boosting, additional doses of vaccine improves humoral cellular...
Australia commenced administration of the Spikevax (Moderna mRNA-1273) COVID-19 vaccine in August 2021 and Nuvaxovid (Novavax NVX-CoV2373) January 2022. This study describes short-term safety profile priming doses vaccines given between September 2023. Online surveys were sent via AusVaxSafety, Australia’s active surveillance system, three eight days after vaccination. A total 131,775 day 3 sent, with a response rate 38.5% (N = 50,721). 43,875 8 matched survey responses 71.5% 31,355). Half...