A5075696368- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Salivary Gland Disorders and Functions
- interferon and immune responses
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
- Reproductive System and Pregnancy
- Cell Adhesion Molecules Research
- University-Industry-Government Innovation Models
- Extracellular vesicles in disease
- Corneal Surgery and Treatments
- Cytomegalovirus and herpesvirus research
- Connexins and lens biology
- MicroRNA in disease regulation
- Educational Innovations and Challenges
- Proteoglycans and glycosaminoglycans research
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Higher Education and Teaching Methods
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Mesenchymal stem cell research
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Platelet Disorders and Treatments
Tianjin Medical University
2019-2025
Tianjin Medical University Eye Hospital
2019-2025
Hubei University of Technology
2008
Purpose: To investigate the role of S100A8/A9 in pathogenesis Sjögren's dry eye disease (SjDED) and explore its potential mechanism action. Methods: expression was determined by western blot quantitative real-time polymerase chain reaction (qRT-PCR). Tear secretion, corneal fluorescein staining, hematoxylin eosin staining were used to evaluate effect paquinimod, a inhibitor, on nonobese diabetic (NOD) mice. Immune cell infiltration percentage assessed immunofluorescence flow cytometry....
Pathogenic T helper (T h )17 cells are key mediators of autoimmune diseases such as uveitis and its animal model, experimental (EAU). However, the contribution microRNAs (miRs) to intrinsic control pathogenic 17 in EAU remains largely unknown. Here, we have reported that miR‐223‐3p was significantly up‐regulated interphotoreceptor retinoid‐binding protein‐specific cells, expression enhanced by IL‐23‐signal transducer activator transcription 3 signaling. Knockdown decreased pathogenicity a...
Pathogenic Th17 cells are critical drivers of multiple autoimmune diseases, including uveitis and its animal model, experimental (EAU). However, how innate immune signals modulate pathogenic responses remains largely unknown. Here, we showed that miR-338-3p endowed dendritic (DCs) with an increased ability to activate interphotoreceptor retinoid-binding protein (IRBP)1-20 -specific by promoting the production IL-6, IL-1β, IL-23. In vivo administration LV-miR-338-infected DCs promoted...
Mesenchymal stem cells (MSCs) represent a promising therapeutic strategy in clinical research for dry eye, and their immunomodulatory effects can be enhanced through genetic modification. In this study, we constructed interleukin-10 (IL-10) gene-modified adipose-derived MSCs (IL-10-ADSCs) investigated protective underlying mechanisms on rabbit autoimmune dacryoadenitis, an animal model of eye. ADSCs were isolated from adipose tissue transduced with IL-10 overexpressing lentivirus. Then the...
Sjögren's syndrome-related dry eye (SS-related eye) is an intractable autoimmune disease characterized by chronic inflammation of lacrimal glands (LGs), where epigenetic factors are proven to play a crucial role in the pathogenesis this disease. However, alteration DNA methylation LGs and its SS-related still unknown. Here, we performed integrated analysis RNA-Seq data identify novel methylation-regulated differentially expressed genes (MeDEGs) eye.The transcription profiles NOD mice at...
Objective To investigate the effect of human umbilical cord mesenchymal stem cells derived exosomes (hUC-MSC-exo) on phenotype peripheral blood macrophages from rabbit autoimmune dry eye and expression related cytokines. Methods The hUC-MSCs were isolated characterized.Exosomes extracted by ultracentrifugation observed directly using electronic microscopy.Specific markers analyzed Western blot.Six rabbits randomly divided into normal control group random number table method, 3 for...
Purpose: To identify the differential expression of microRNAs (miRs) and related gene networks signal pathways in lacrimal glands (LGs) rabbit autoimmune dacryoadenitis.Methods: Autoimmune dacryoadenitis rabbits was induced by transferring activated peripheral blood lymphocytes (PBLs).The LGs normal model group were collected for small RNA sequencing.The most differentially expressed miRs validated quantitative real time-polymerase chain reaction (qRT-PCR).Further, bioinformatics analysis...
Abstract We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated autoimmune dacryoadenitis in rabbits. Recently, MSC-derived exsomes (MSC-Exo) were considered to carry functions of MSCs. In this study, we investigated the effect local administration human MSC-Exo on rabbit dacryoadenitis. Diseased rabbits treated with or PBS via subconjunctival injection days 1, 3, 5, 7 and 9 after infusions activated autologous lymphocytes, clinical scores determined by assessing tear...