A5052725471- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Medical Imaging and Analysis
- Spondyloarthritis Studies and Treatments
- RNA modifications and cancer
- Bone health and treatments
- Electromagnetic Fields and Biological Effects
- Anesthesia and Pain Management
- NF-κB Signaling Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pelvic and Acetabular Injuries
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cytokine Signaling Pathways and Interactions
- Veterinary medicine and infectious diseases
- Lung Cancer Diagnosis and Treatment
- Occupational Health and Performance
- Bone fractures and treatments
- Spinal Hematomas and Complications
- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
First Affiliated Hospital of Xiamen University
2012-2025
Fujian Medical University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Anhui Provincial Children's Hospital
2022
Air Force Medical University
2019-2022
Ministry of Education of the People's Republic of China
2020-2022
National Health and Family Planning Commission
2020
Beijing Hospital
2011-2019
Xiamen University
2013
University of Houston
2012
The Lancet Commission on Global Surgery established the Three Delays framework, categorising delays in accessing timely surgical care into seeking (First Delay), reaching (Second and receiving (Third Delay). Globally, knowledge gaps regarding for fracture care, lack of large prospective studies informed rationale our international observational study. We investigated hospital admission as a surrogate explored factors associated with delayed admission.
Surface structures and physicochemical properties critically influence osseointegration of titanium (Ti) implants. Previous studies have shown that the surface with both micro- nanoscale roughness may provide multiple features comparable to cell dimensions thus efficiently regulate cell-material interaction. However, less attention has been made further optimize (e.g., crystalline phase) improve bioactivity micro/nanostructured surfaces. Herein, titania surfaces different phases (amorphous,...
Abstract Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore underlying mechanism, we investigated neuroprotective cathodal tDCS on injury caused by middle cerebral artery occlusion (MCAO). Results We established MCAO model and sham with an epicranial electrode implanted adult male Sprague–Dawley rats, then they were randomly divided into four groups...
Aberrant expression and function of retinoic acid receptor γ (RARγ) are often involved in the progression several cancers. However, role RARγ cholangiocarcinoma (CCA), chemoresistant bile duct carcinoma with a poor prognosis, remains unclear. In present study, we found that was frequently overexpressed human CCA specimens. Its overexpression associated differentiation, lymph node metastasis, high serum carbohydrate antigen 19-9 level, prognosis CCA. Downregulation reduced cell proliferation,...
Hierarchical surface structures with micro-nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation. It has been proven that cells are extremely sensitive to the nanoscaled structure show multifarious phenotypes. Though vital function microstructure on osseointegration confirmed, performances response different microscaled is needed be further dissected depth understood. In this work, ordered hierarchical varying micro-scaled pits were precisely...
Osteoporosis is a serious public health problem that results in fragility fractures, especially postmenopausal women. Because the current therapeutic strategy for osteoporosis has various side effects, safer and more effective treatment worth exploring. It important to examine natural plant extracts during new drug design due low toxicity. Mogrol an aglycon of mogroside, which active component Siraitia grosvenorii (Swingle) exhibits anti-inflammatory, anticancer neuroprotective effects....
The weight-adjusted-waist index (WWI) is a novel obesity that calculated as the waist circumference (WC) divided by square root of body weight (kg). Previous studies have revealed higher mass (BMI) and WC increase risk low back pain (LBP). However, no research explores relationship between WWI LBP. Data utilized in this cross-sectional study were drawn from National Health Nutrition Examination Survey (NHANES). Three logistic regression models used to evaluate association LBP, stratified...
Estimated glucose disposal rate (eGDR) is a novel insulin resistance (IR) assessment surrogate. Although it has shown promising potential in other metabolic disease studies, no research yet explored its relationship with osteoarthritis (OA). Therefore, this study aims to investigate the association between eGDR and OA cross-sectional observational cohort. Data utilized were drawn from National Health Nutrition Examination Survey (NHANES). Logistic regression models used evaluate OA,...
Osteoarthritis (OA) is a common chronic disease among the elderly, causing pain, functional limitations, and decline in quality of life. Diabetes mellitus (DM), prevalent metabolic disorder, has been proven to have an association with OA. However, specific impact DM on physical function OA patients remains lack in-depth exploration. This study aims investigate whether (DMOA) experience more severe limitations. The utilized National Health Nutrition Examination Survey (NHANES) data from...
Insulin resistance is one of the major pathophysiological features type 2 diabetes mellitus. Studies have revealed association between mellitus and low back pain. However, few studies explored relationship insulin pain directly. Therefore, this study selected HOMA-IR, TyG, TyG-BMI, TyG-WC, TyG-WtHR as indicators to comprehensively investigate The data for cross-sectional were from NHANES. Multivariate logistic regression was used assess with pain, stability results evaluated by stratified...
Abstract Background Cyclin kinase subunit‐2 (Cks2), a member of the human Cks family, plays an important role in regulation meiosis and mitosis; its abnormal expression is usually associated with carcinogenesis. However, exact functions molecular mechanisms remain unclear. Aims To observe Cks2 cholangiocarcinoma explore carcinogenesis possible mechanism. Methods was detected immunostaining RT ‐ PCR . MTT , colony formation, immunofluorescence, flow cytometry Western blotting were performed...
Background. Ischemic stroke carries a high mortality rate and is leading cause of severe neurological disability. However, the efficacy current therapeutic options remains limited. Objective. We aimed to investigate treatment transcranial direct stimulation (tDCS) in motor function rehabilitation after ischemic explore underlying mechanisms. Methods. Male Sprague-Dawley rats with epicranial electrodes were used establish pathogenetic model through temporary right middle cerebral artery...
Osteonecrosis of the femoral head (ONFH) is a devastating disease characterized by destructive bone structures, enlarged adipocyte accumulation and impaired vascularization. The aldehyde dehydrogenase 2 (ALDH 2) limiting enzyme for ethanol metabolism with many physiological functions. aim was investigated potential protective role activated ALDH Alda-1 ethanol-induced ONFH.The ONFH in rat performed to explore various experimental methods. Subsequently, effect on osteogenic adipogenic...
Background Autoimmune diseases (ADs) are a category of conditions characterized by misrecognition autologous tissues and organs the immune system, leading to severe impairment patients’ health quality life. Increasing evidence suggests connection between fluctuations in plasma metabolites ADs. However, existence causal relationship behind these associations remains uncertain. Methods Applying two-sample mendelian randomization (MR) method, reciprocal causality ADs was analyzed. We took...
Reactive oxygen species (ROS) play both deleterious and beneficial roles in cancer cells. Nucleophosmin (NPM) is heavily implicated cancers of diverse origins, being its gene over-expression solid tumors or frequent mutations hematological malignancies. However, the role regulatory mechanism NPM oxidative stress are unclear. Here, we found that regulated expression peroxiredoxin 6 (PRDX6), a member thiol-specific antioxidant protein family, consequently affected level distribution ROS. Our...
5.8 GHz spectrum is gaining more attention in wireless technology. To explore the potential hazards, we investigated effect of exposure to microwave on learning and memory ability rats. Methods: Morris Water maze (MWM), Novel object recognition (NOR) Fear conditioning test (FCT) were used evaluate spatial non-spatial The hippocampal morphology, level brain injury factors serum mitochondrial membrane neurons was examined damage neurons. density dendritic spines, ultrastructure synapses PSD95,...