A5077604487- Renal Transplantation Outcomes and Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Vascular Malformations Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Pregnancy and Medication Impact
- Surgical Simulation and Training
- Microscopic Colitis
- Diverticular Disease and Complications
- Immune Cell Function and Interaction
- Facial Nerve Paralysis Treatment and Research
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- Colorectal Cancer Screening and Detection
City of Hope
2025
Universidad de Los Andes, Chile
2015-2024
Hospital Nacional Dos de Mayo
2023
National University of San Marcos
2023
University of Southern California
2023
Hospital Clínico de la Universidad de Chile
1991-2023
Universidad de La Frontera
2023
University of Chile
2005-2021
Clínica Las Condes
2005-2021
Bicêtre Hospital
2021
Abstract Introduction Sepsis is a clinical syndrome associated with severe systemic inflammation induced by infection. Although different anti-microbial drugs have been used as treatments, morbidity and mortality rates remain high. Mesenchymal stem cells (MSCs) derived from the bone marrow demonstrated partial protective effect in sepsis. Menstrual MSCs (MenSCs) emerge an attractive candidate because they present important advantages over other sources, including improved proliferation...
Metastatic translocation renal cell carcinomas (mtRCCs) are rare and aggressive tumors with limited treatment options. Recent studies demonstrated promising activity of immune-oncology (IO) combinations in mtRCC. However, the effectiveness dual IO versus plus VEGF-TKI remains unclear. We conducted a retrospective analysis mtRCC patients at 4 institutions. Eligible had confirmed by genitourinary pathologist received combination therapy (IO+IO or IO+VEGF-TKI). Clinical data outcomes were...
Mesenchymal stem cells (MSCs) secrete exosomes that are capable of modifying the tumor environment through different mechanisms including changes in cancer-cell secretome. This activity depends on their cargo content is largely defined by cellular origin. Endometrial fine regulators angiogenic process during menstrual cycle includes an angiostatic condition associated with end cycle. Hence, we studied (MenSCs)-secreted prostate PC3 cells. Our results showed induce a reduction VEGF secretion...
New levels of reproducibility and sensitivity have been achieved in the detection anticysticercus antibodies human sera by using cysticercus vesicular fluid as source antigens for both ELISA hemagglutination assays. Reproducibility between tests on a serum similar was significantly improved over typical results from whole parasite extracts. Sera collected uninfected individuals endemic areas gave somewhat elevated values those nonendemic areas. This necessitated use higher threshold to avoid...
Recommendations of the Chilean association for digestive endoscopyfor management gastric pre-malignant lesionsAn expert panel analyzed available evidence and reached a consensus to release 24 recommendations primary secondary prevention cancer (CG) in symptomatic patients, with indication upper GI endoscopy.The main include (1) Search eradicate H. pylori infection all cases.(2) Systematic biopsies (Sydney protocol) patients over 40 years age or first grade relatives patient CG, detect...
Prone positioning is currently applied in time-limited daily sessions up to 24 h which determines that most patients require several sessions. Although longer prone have been reported, there scarce evidence about the feasibility and safety of such approach. We analyzed a continuous prolonged strategy implemented nationwide, large cohort COVID-19 Chile.Retrospective study mechanically ventilated with moderate-to-severe acute respiratory distress syndrome (ARDS), conducted 15 Intensive Care...
Abstract: Steroids have been a cornerstone in renal transplant immunosuppression. New immunosuppressive drugs led to protocols using early steroid withdrawal or complete avoidance. A prospective protocol 23 pediatric (ages 2–14 yr) who received decreasing doses stopping at day 7 post‐Tx, FK, and MMF were compared with CsA, AZT, historically matched steroid‐based control group. Basiliximab was used two doses. Anthropometric, biochemical variables, AR rates, CMV infection evaluated Student’s...
The aims of the present study were to assess prevalence fatal adverse drug reactions (FADRs) in a hospitalized population, identify drugs involved and investigate reported risk factors for these events.The population this retrospective, single-centre case comprised 289 patients dying between 1 January 2004 31 December registered Cause Death Register teaching hospital. All compiled data recorded by two observers especially trained report (ADRs). degree probability that ADR led directly death...
Lower blood levels of the omega-3 polyunsaturated fatty acid docosahexaenoic (DHA) are correlated with worse cognitive functions, particularly among APOE ε4 carriers. Whether DHA supplementation in carriers limited consumption and dementia risk factors can delay or slow down disease progression when started before onset clinical is not known. PreventE4 a double-blind, single site, randomized, placebo-controlled trial cognitively unimpaired individuals (n=368). Its objectives to determine (1)...
A screening program for colorectal cancer inChilean subjects aged fi fty years or more Background: Mortality from (CCR) in Chile has nearly doubled over the past 15 years.International studies have shown that CCR programs based on fecal occult blood test (FOBT) reduce mortality.Aim: To analyze results a model people 50 years.Material and Methods: Between 2007 and2009, prospective multicenter study was performed seven major Chilean cities. FOBT using an immunological method, measured...
Selection of patients with Lynch Syndrome (LS) for a genetic study involves the application clinical criteria. To increase rate identification mutations, use molecular studies as Microsatellite Instability (MSI) and Immunohistochemistry (IHC) in tumor has been proposed.To demonstrate usefulness MSI IHC detection mutations LS.From our Familial Colorectal Cancer Registry, families suspected LS were selected according to Amsterdam or Bethesda Screening germline MLH1, MSH2 MSH6 genes was...
Colorectal cancer is a multistep process affecting several signaling pathways including EGFR (epidermal growth factor receptor), therapeutic target for metastatic disease. Our aim was to characterize the mutational and expression profiles of pathway in colorectal tumors integrate these results according five previously defined groups. We screened seven genes mutations ( KRAS-BRAF-PIK3CA-PIK3R1-AKT1-MAP2K1-PTEN) six proteins (EGFR-p110α-p85α-PTEN-phosphoAKT-phosphoMEK1) by...
25% of Stage III colon cancer patients relapse within 5 years due to minimal residual disease (MRD) not eliminated by surgery and chemotherapy. We hypothesise that sub-types MRD, defined circulating tumour cells (CTCs) bone marrow micro-metastasis (mM) have different types kinetics relapse.One month curative 1 after completing six cycles FOLFOX chemotherapy blood samples were taken detect CTCs mM using immunocytochemistry with anti-carcino-embryonic antigen (CEA). Follow up was or...
Atrofia muscular espinal: Caracterización clínica
Dear Editor: Mesalamine is a medication used widely in the treatment of patients with inflammatory bowel disease. Although mesalamine considered safe, hepatotoxicity has been reported an incidence 0-4%. We present clinical picture patient due to mesalamine. A 79-year-old woman context chronic diarrhea, left-sided ulcerative colitis diagnosis was made, and initiated oral 4 g per day, suppositories. Before starting treatment, she had normal liver test results. After three months, presented...
On renal ischemia-reperfusion (I/R) injury, recruitment of neutrophils during the inflammatory process promotes local generation oxygen and nitrogen reactive species, which, in turn, are likely to exacerbate tissue damage. The mechanism by which inducible nitric oxide synthase (iNOS) is involved I/R has not been elucidated. In this work, selective iNOS inhibitor l- N6-(1-iminoethyl)lysine (l-NIL) NOS substrate l-arginine were employed understand role activity on expression particular target...
Background: In this paper, we report a clinical series of skull base lesions operated on trough the MiniPT, extending its application to lesions, either using classical minipterional or variant, call extradural approach (MiniPTEx). Methods: We describe our surgical technique operating complex approach. Anterior clinoidectomy, middle fossa peeling, transcavernous, and Kawase approaches were performed as needed. total, carried out 24 surgeries: three tumors, 1 Moyamoya case, 20 giant/complex...
This work aimed to study the effect of uteroplacental circulation restriction on endothelial kidney damage in a fetal rabbit model.New Zealand rabbits were subjected 40% 50% artery ligation at day 25 pregnancy. After 5 days, surviving fetuses harvested by cesarean section. The gene and protein expressions selected enzymes associated with nitric oxide production oxidative stress analyzed homogenates.The placenta weight (6.06 ± 0.27, p < 0.0319) body (19.90 1.03, 0.0001) significantly reduced...