A5085313823- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Neuroscience and Music Perception
- Bacterial Genetics and Biotechnology
- NMR spectroscopy and applications
- Neurotransmitter Receptor Influence on Behavior
- Drug Transport and Resistance Mechanisms
- Magnetic and Electromagnetic Effects
- Lanthanide and Transition Metal Complexes
- Bone and Joint Diseases
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Photoreceptor and optogenetics research
Forschungszentrum Jülich
2013-2023
Until recently, no direct comparison between [ 15 O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a becomes feasible. This study presents results CBF measurements recorded simultaneously with ASL. A 3T MR-BrainPET scanner used simultaneous acquisition pseudo-continuous ASL (pCASL) imaging (MRI) PET. Quantitative values were...
Targeting toxic amyloid beta (Aβ) oligomers is currently a very attractive drug development strategy for treatment of Alzheimer´s disease. Using mirror-image phage display against Aβ1-42, we have previously identified the fully D-enantiomeric peptide D3, which able to eliminate Aβ and has proven therapeutic potential in transgenic disease animal models. However, there little information on pharmacokinetic behaviour peptides general. Therefore, conducted experiments with tritium labelled...
The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation functional magnetic resonance imaging (fMRI) electroencephalography (EEG) signals. However, their association with balance between excitation inhibition (E/I-B), which closely related to glutamate γ-aminobutyric acid (GABA) receptor availability (RA) GABAA mGluR5, remains unexplored. This research investigates these associations during resting state (RS) condition using simultaneously recorded...
Simultaneous trimodal positron emission tomography/magnetic resonance imaging/electroencephalography (PET/MRI/EEG) resting state (rs) brain data were acquired from 10 healthy male volunteers. The rs-functional MRI (fMRI) metrics, such as regional homogeneity (ReHo), degree centrality (DC) and fractional amplitude of low-frequency fluctuations (fALFFs), well 2-[18F]fluoro-2-desoxy-d-glucose (FDG)-PET standardised uptake value (SUV), calculated the measures extracted default mode network (DMN)...
Abstract Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, role metabotropic receptors type 5 (mGluR5) this disease remains unclear. In study, we investigated their significance (using [ 11 C]ABP688) for psychopathology and cognition male patients with chronic schizophrenia healthy controls. patient group, lower mGluR5 binding potential (BP ND...
O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is a widely used amino acid tracer for positron emission tomography (PET) imaging of brain tumours. This retrospective study and survey aimed to analyse our extensive database regarding the development FET PET investigations, indications, referring physicians' rating concerning role in clinical decision-making process. Between 2006 2019, we performed 6534 scans on 3928 different patients against backdrop growing demand PET. In indications use were as...
Simultaneous MR-PET-EEG (magnetic resonance imaging - positron emission tomography electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here first time. It enables assessment molecular metabolic information with high spatial and temporal resolution given brain simultaneously. Here, we characterize brain's default mode network (DMN) healthy male subjects using multimodal fingerprinting by quantifying energy metabolism via 2-...
PET imaging of amino acid transport using <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) and proton MR spectroscopy (MRS) cell turnover measured by the ratio choline to <i>N</i>-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. <b>Methods:</b> In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 14 y) (World Health Organization...
Abstract Currently, the metabotropic glutamate receptor 5 (mGluR5) is subject of several lines research in context neurology and high interest as a target for positron-emission tomography (PET). Here, we assessed feasibility using [ 11 C]ABP688, specific antagonist radiotracer an allosteric site on mGluR5, to evaluate changes glutamatergic neurotransmission through mismatch-negativity (MMN) task part simultaneous synchronized multimodal PET/MR-EEG study. We analyzed effect MMN by comparing...
Building on the success of positron emission tomography (PET)/CT scanners, a hybrid imaging technology, combining PET with versatile attributes magnetic resonance (MRI), has been in use for over ten years. At Forschungszentrum Jülich, one four prototypes available worldwide, commercial 3T MRI newly developed BrainPET insert, was installed 2008, allowing simultaneous data acquisition and MRI. Here, we report our ten-year-long experience methods technology through this paper numerous patients...
Abstract The glutamate and γ‐aminobutyric acid neuroreceptor subtypes mGluR 5 GABA A are hypothesized to be involved in the development of a variety psychiatric diseases. However, detailed information relating their vivo distribution is generally unavailable. Maps such distributions could potentially aid clinical studies by providing reference for normal neuroreceptors may also useful as covariates advanced functional magnetic resonance imaging (MR) studies. In this study, we propose...
Advanced MRI methods and PET using radiolabeled amino acids provide valuable information in addition to conventional MR imaging for brain tumor diagnostics. These are particularly helpful challenging situations such as the differentiation of malignant processes from benign lesions, identification non-enhancing glioma subregions, progression treatment-related changes, early assessment response anticancer therapy. The debate over which is preferable situation ongoing has been addressed...
Trimodal simultaneous acquisition of positron emission tomography (PET), magnetic resonance imaging (MRI), and electroencephalography (EEG) has become feasible due to the development hybrid PET-MR scanners. To capture temporal dynamics neuronal activation on a millisecond-by-millisecond basis, an EEG system is appended quantitative high resolution modality already established in our institute. One major difficulties associated with trimodal that components traditionally used each can cause...
Due to technological developments in positron emission tomography (PET) detectors and PET-MR integration, the simultaneous measurement of PET-MR-EEG has become feasible, offering possibility exploring complementary information provided by each modality. Studies have already shown benefits using PET-MR, however, such achievements come with different technical practical challenges. In this context, we aim give an overview challenges involved integrating electroencephalography hybrid scanners...
Body mass index (BMI) is increasing in a large number of elderly persons. This increase BMI known to put one at risk for many "diseases aging," although less about how change may affect the brains elderly.To investigate relationship between and quantitative water content, T1 , T2 *, semi-quantitative magnetization transfer ratio (MTR) various structures brains.Cross-sectional.Forty-two adults (BMI range: 19.1-33.5 kg/m2 age 58-80 years).3T MRI (two multi-echo gradient echoes, actual flip...
Radiological differentiation of tumor progression (TPR) from treatment-related changes (TRC) in pretreated glioblastoma is crucial. This study aimed to explore the diagnostic value diffusion kurtosis MRI combined with information derived O-(2-[18F]-fluoroethyl)-l-tyrosine (18F-FET) PET for TPR TRC patients glioblastoma.Thirty-two histomolecularly defined and suspected having were included this retrospective study. Twenty-one group, 11 as assessed by neuropathology or clinicoradiological...
Contrast-enhanced MRI is the method of choice for brain tumor diagnostics, despite its low specificity tissue. This study compared contribution MR spectroscopic imaging (MRSI) and amino acid PET to improve detection <b>Methods:</b> In 30 untreated patients with suspected glioma, <i>O</i>-(2-[<sup>18</sup>F]fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) PET; 3-T MRSI a short echo time; fluid-attenuated inversion recovery, T2-weighted, contrast-enhanced T1-weighted were performed stereotactic...
In the past, eloquent areas could be deliberately localised by invasive Wada test. The very rare cases of dissociated crossed speech were accidentally found based on clinical symptomatology. Today functional magnetic resonance imaging (fMRI)-based can employed to non-invasively localise in brain tumour patients for therapy planning. A 41-year-old, left-handed man with a low-grade glioma left frontal operculum extending insular cortex, tension headaches, and anomic aphasia over 5 months...
Head motion can degrade accuracy of time activity curves (TAC) in quantitative neuroimaging; this becomes especially true for long PET acquisition protocols. Apart from misalignment regions interest, also a bias occurs due to mismatches between the subject attenuation map (AM) fixed reference position and various head positions. Any mismatch causes correction (AC), but scatter (SC) which usually depends on AM. Thus, (MC) is prerequisite quantification. Where no external tracking device...
In addition to MR imaging, PET imaging of O-(2-[18F]Fluorethyl)-L-Tyrosine (FET) uptake provides information on brain tumour extent and metabolic activity. Similarly, MRS has been shown be value for distinguishing high- from low-grade gliomas. Based 2D spatially resolved MRSI, an overlap between 18FET the choline/N-acetyl-aspartate (Cho/NAA) ratio more than 75 % reported.
The use of hybrid PET/MR imaging facilitates the simultaneous investigation challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state PET radiotracer bolus-infusion protocol, it is possible observe alterations neuroreceptor through distribution volumes. Here, we present an iterative procedure for establishing administration scheme obtain [11C]flumazenil concentrations grey...
Abstract The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation functional magnetic resonance imaging (fMRI) electroencephalography (EEG) signals. However, their association with balance between excitation inhibition (E/I-B), which closely related to glutamate GABA (γ -aminobutyric acid) receptor availability (RA) A mGluR5, remains unexplored. This study investigates these associations during resting state (RS) condition using simultaneously...