A5073263476- Advanced Topics in Algebra
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Simulation and Modeling Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Anesthesia and Neurotoxicity Research
- Ubiquitin and proteasome pathways
- Diet and metabolism studies
- Safety and Risk Management
- Cancer, Stress, Anesthesia, and Immune Response
- Traffic Prediction and Management Techniques
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Autonomous Vehicle Technology and Safety
- Explainable Artificial Intelligence (XAI)
- Multimodal Machine Learning Applications
- Quantum Mechanics and Applications
- Peroxisome Proliferator-Activated Receptors
- IoT and GPS-based Vehicle Safety Systems
- Advanced Operator Algebra Research
- Antimicrobial Peptides and Activities
- Respiratory viral infections research
- Nutrition, Genetics, and Disease
- Single-cell and spatial transcriptomics
Yunnan Academy of Forestry
2025
North Sichuan Medical University
2025
Southeast University
2010-2025
Affiliated Hospital of Southwest Medical University
2023-2025
Jilin University
2022-2024
Medical University of Sofia
2024
Soochow University
2023
Fudan University
2000-2023
Central South University
2015-2023
First Affiliated Hospital of Soochow University
2023
// Ningning Liu 1,2,* , Xiaofen Li 1,* Hongbiao Huang Chong Zhao Siyan Liao Changshan Yang Shouting Wenbin Song 1 Xiaoyu Lu Xiaoying Lan Xin Chen Songgang Yi Xu 1,3 Lili Jiang Canguo Xiaoxian Dong Ping Zhou Shujue 1,4 Shunqing Wang Xianping Shi Q. Dou 1,5 Xuejun 1,6 and Jinbao State Key Lab of Respiratory Disease, Protein Modification Degradation Lab, Department Pathophysiology, Guangzhou Medical University, Guangdong, China 2 Research Institute Cardiovascular the Second Affiliated Hospital,...
Abstract Purpose: Chronic myelogenous leukemia (CML) is characterized by the constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl-T315I predominant mutation that causes resistance to imatinib, cytotoxic drugs, and second-generation kinase inhibitors. The emergence imatinib in patients with CML leads searching for novel approaches treatment CML. Gambogic acid, a small molecule derived from Chinese herb gamboges, has been approved phase II clinical trial cancer therapy Food Drug...
An anticorrosive coating with randomly distributed passive barriers and regionally enriched active corrosion inhibitors is developed by integrating mica nanosheets (MNSs) magnetic-responsive core–shell mesoporous nanoparticles 2-mercaptobenzothiazole (Fe3O4@mSiO2/MBT) under magnetic field incubation. The bottom Fe3O4@mSiO2/MBT rapidly releases the MBT to form a passivation layer on sites, enhancing inhibition efficiency 30.36% compared control (NP0.7EP-R). impedance modulus |Z|0.01 Hz of...
L-carnitine (LC) is generally believed to transport long-chain acyl groups from fatty acids into the mitochondrial matrix for ATP generation via citric acid cycle. Based on Warburg's theory that most cancer cells mainly depend glycolysis generation, we hypothesize that, LC treatment would lead disturbance of cellular metabolism and cytotoxicity in cells. In this study, Human hepatoma HepG2, SMMC-7721 cell lines, primary cultured thymocytes mice bearing HepG2 tumor were used. content was...
This article aims to develop CeO
Background: Glioma is one of the most common malignancies central nervous system in adults. The lncRNA PTEN pseudogene-1 (PTENP1) has been reported to play an important role development and progression various cancers. However, molecular mechanism by which PTENP1 affects gliomas remains unclear. Materials methods: levels expression glioma tissues normal brain were detected quantitative real-time PCR. Cell Counting Kit-8 5-ethynyl-2'-deoxyuridine staining assays performed detect cell...
Chemotherapy resistance is one of the major obstacles to effective glioma therapy. Currently, mechanism underlying chemotherapy unclear. A recent study showed that miR-106a an important molecule involved in resistance. To explore effects and mechanisms on multidrug reversal human cells, we silenced expression cisplatin-resistant U87 (U87/DDP) gefitinib-resistant U251 (U251/G) cell lines measured resulting drug sensitivity, apoptosis rate rhodamine 123 content. In addition, detected decreased...
Previous reports demonstrated the anticancer effects and protective on cardiovascular diseases of vinegar products. The molecular mechanism underlying these phenomena is not well elucidated. It was proposed that carcinogenesis triggered by formation local strong acids such as HCl. Cancer cells may overproduce weak or moderate organic oxalate to antagonize acids, calcium cause organ failure death. This study aimed at elucidating antagonism apoptosis acetate oxalate. Quantitation cell HEK293T...
Background: Esophageal cancer is a highly lethal with rapidly increasing incidence and poor prognosis. Atractylenolide I natural sesquiterpene lactone extracted from the rhizome of Asteraceae plant, which has variety pharmacological effects, such as anti-inflammatory immunomodulatory. Still, its impact on esophageal not been reported. Therefore, this study investigated in vitro vivo effects growth proliferation explored possible mechanisms. Methods: To evaluate effect atractylenolide cells,...
The etiology of Hashimoto's thyroiditis (HT) is diverse. correlation between educational attainment (EA) and health also a research hotspot. This study explores the relationship EA HT from genetic perspective. Summary data on were sourced MRC Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Studies (GWAS) database. Utilizing single nucleotide polymorphisms (SNPs) that are strongly associated with as instrumental variables, we estimated causal through two-sample mendelian...
Combinations of proteasome inhibitors and histone deacetylases (HDAC) appear to be the most potent produce synergistic cytotoxicity in preclinical trials. We have recently confirmed that L-carnitine (LC) is an endogenous HDAC inhibitor. In current study, anti-tumor effect LC plus inhibitor bortezomib (velcade, Vel) was investigated both cultured hepatoma cancer cells Balb/c mice bearing HepG2 tumor. Cell death cell viability were assayed by flow cytometry MTS, respectively. Gene, mRNA...
Surgical training traditionally adheres to the apprenticeship paradigm, potentially exposing trainees an increased risk of complications stemming from their limited experience. To mitigate this risk, augmented and virtual reality have been considered, though effectiveness is difficult assess. The PASSION study seeks investigate improvement manual dexterity following intensive with neurosurgical simulators discern how surgeons´ psychometric characteristics may influence learning process...
The present study identified the cytotoxic effects of etomidate on N2a neuroblastoma cell line. Etomidate induced apoptosis in cells a concentration‑dependent manner, which was confirmed by western blotting and flow cytometry. Phase contrast microscopy used to analyze effect morphological characteristics. number apoptotic increased DAPI PI staining, served as characteristic hallmark apoptosis. Additionally, led loss mitochondrial membrane potential resulted generation reactive oxygen species...