A5052865472- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Anesthesia and Pain Management
- Fungal and yeast genetics research
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Mycorrhizal Fungi and Plant Interactions
- Wind and Air Flow Studies
- Fungal Biology and Applications
- RNA Research and Splicing
- Musculoskeletal pain and rehabilitation
- RNA modifications and cancer
- Nausea and vomiting management
- Approximation Theory and Sequence Spaces
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Plant Stress Responses and Tolerance
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric health and respiratory diseases
- PI3K/AKT/mTOR signaling in cancer
- Iterative Methods for Nonlinear Equations
- Spine and Intervertebral Disc Pathology
University of Hong Kong
2023-2025
Queen Mary Hospital
2025
Chinese University of Hong Kong
2023-2024
Heilongjiang Bayi Agricultural University
2020-2022
Fujian Medical University
2022
First Affiliated Hospital of Xiamen University
2022
Hangzhou Normal University
2021-2022
Institute of Botany
2022
Chinese Academy of Sciences
2022
Hong Kong Polytechnic University
2011-2020
Lung cancer is one of the most common deadly diseases worldwide, which non-small cell lung (NSCLC). The epidermal growth factor receptor (EGFR) mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (EGFR-TKIs) treatment, such as Gefitinib and Erlotinib, but development acquired resistance limits utility. Multiple mechanisms have been explored, e.g. activation alternative receptors (TKRs) sharing similar downstream pathways EGFR. MicroRNAs (MiRNAs) are short, endogenous...
Background The analgesic effect of adding liposomal bupivacaine to standard in supraclavicular brachial plexus block is not known. authors hypothesized that addition would reduce acute postoperative pain compared alone. Methods A randomized controlled trial was conducted. Patients and outcome assessors were blinded. Eighty patients undergoing distal radial fracture fixation during regional anesthesia with into two groups. group received 10 ml 0.5% plain immediately followed by 1.33% (n =...
Mushroom-forming basidiomycetes colonize large areas in nature. Their hyphae are compartmentalized by perforated septa, which usually covered a septal pore cap (SPC). Here, we describe, for the first time, composition and function of SPCs using model system Schizophyllum commune. The SPC S. commune was shown to consist proteinaceous matrix lipid membrane. demonstrated define ultrastructure two main proteins, Spc14 Spc33. Gene spc14 encodes protein 86 amino acids, lacks known domain, signal...
Gene deletion in Schizophyllum commune is hampered by a low incidence of homologous integration. As consequence, extensive screening required to identify transformant with the desired genotype. To alleviate this and facilitate assembly plasmids, vector pDelcas was constructed. This construct has set restriction sites, which allows for directional cloning flanking sequences at both sides nourseothricin resistance cassette. Moreover, it contains phleomycin cassette elsewhere plasmid, used...
Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation often initially respond to EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment but may acquire drug resistance due multiple factors. MicroRNAs are a class of small noncoding and endogenous RNA molecules that play role in overcoming the resistance.
Molecular imaging probes can target abnormal gene expression patterns in patients and allow early diagnosis of disease. For selecting a suitable probe, the current Imaging Contrast Agent Database (MICAD) provides descriptive qualitative information on probe characteristics properties. However, MICAD does not support linkage with profiles genes. The proposed Disease-specific Probe Profiling (DIPP) database quantitatively archives presents targets across different diseases, anatomic regions,...
Lumbar prolapsed disc (LPD) is a leading cause of low back pain, contributing significantly to global disability and healthcare burden. This study aimed develop machine learning models predict the risk LPD by analysing gene expression profiles for early detection. Transcriptomic data from peripheral blood samples were obtained Gene Expression Omnibus (GEO) database, with dataset GSE150408 used training GSE124272 testing. The included 17 patients sciatica resulting LPD, all whom had magnetic...
Cardiomyopathy is a clinical problem that occurs in the hearts of type 2 diabetic patients as well cancer undergoing doxorubicin chemotherapy. The number increasing but surprisingly cardiac damaging effects doxorubicin, commonly used chemotherapeutic drug, on have not been well-examined. As signaling mechanisms doxorubicin-induced cardiomyopathy heart are largely unknown, this study examined molecular pathways responsible for cardiotoxicity hearts. Male 14- to 18-week-old db/db mice were...
Background . MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. It an important factor for tumorigenesis of colorectal cancer (CRC), potential biomarker diagnosis, prognosis, therapy CRC. Our objective to identify the related miRNAs their associations with genes frequently involved in CRC microsatellite instability (MSI) chromosomal (CIN) signaling pathways. Results A regression model was adopted significantly associated targeting set...
Non-small cell lung cancer (NSCLC) comprises about 84% of all cancers. Many treatment options are available but the survival rate is still very low due to drug resistance. It has been found that phosphoinositide-3-kinase (PI3K) affects sensitivity tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib. Expression level Seven In Absentia Homolog 2 (SIAH2), an E3 ubiquitin-protein ligase, upregulated in NSCLC correlated with tumor grade. However, relationship between PI3K SIAH2...
Lung cancer is the top killer worldwide with high mortality rate. Majority belong to non-small cell lung cancers (NSCLCs). The epidermal growth factor receptor (EGFR) has been broadly explored as a drug target for therapy. However, responses are not durable due acquired resistance. MicroRNAs (miRNAs) small non-coding and endogenous molecules that can inhibit mRNA translation initiation degrade mRNAs. We wonder if some downstream shared by EGFR other tyrosine kinase receptors (TKRs) further...
The prevalence rate of depression is higher in patients with fibromyalgia syndrome, but this often unrecognized chronic pain. Given that a common major barrier the management an objective tool reliably predicts syndrome could significantly enhance diagnostic accuracy. Since pain and can cause each other worsen other, we wonder if pain-related genes be used to differentiate between those from without. This study developed support vector machine model combined principal component analysis...