A5115595399- Renal and related cancers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Heat shock proteins research
- RNA Research and Splicing
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Lipid Membrane Structure and Behavior
- Colorectal Cancer Screening and Detection
- Organ Donation and Transplantation
- Structural Integrity and Reliability Analysis
- Cancer-related gene regulation
- Chronic Kidney Disease and Diabetes
- Phagocytosis and Immune Regulation
- Metabolomics and Mass Spectrometry Studies
- Micro and Nano Robotics
- Berberine and alkaloids research
- Tropical and Extratropical Cyclones Research
- Cell death mechanisms and regulation
- Plant pathogens and resistance mechanisms
- Cholesterol and Lipid Metabolism
Institute of Atmospheric Physics
2025
Chinese Academy of Sciences
2011-2025
University of Chinese Academy of Sciences
2025
Brigham and Women's Hospital
2020-2025
Capital Medical University
2021-2024
Beijing Friendship Hospital
2024
Zhejiang University
2024
Xi’an University of Posts and Telecommunications
2024
Capital University
2024
China Pharmaceutical University
2021-2023
Abstract Sonic hedgehog (SHH) and heat shock protein 90β (HSP90β) have been implicated in nonalcoholic steatohepatitis (NASH) but their molecular mechanisms of action remain elusive. We find that HSP90β is a key SHH downstream molecule for promoting NASH process. In hepatocytes, reduces ubiquitylation through deubiquitylase USP31, thus preventing degradation hepatic lipid synthesis. significantly increases mouse model, leading to secretion exosomes enriched with miR-28-5p. miR-28-5p directly...
Prostate cancer (PCa) is a destructive malignancy with bad prognosis. LncRNA VPS9D1-AS1 has recently been delineated as an oncogene in some kinds of tumor, whereas, the function PCa remains to be clarified. In this study, we researched its underlying role PCa. The expression was conspicuously upregulated tissues and cells. And absence inhibited cell proliferation, migration invasion, promoted apoptosis addition, overexpression led opposite results. Furthermore, VPS9D1-AS1/MEF2D could sponge...
Abstract Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve genome-editing efficiency, but the specific protein that farrerol directly targets regulate HR and underlying molecular mechanisms have not been determined. Here, we find deubiquitinase UCHL3 is direct target of farrerol. Mechanistically, enhanced activity promote RAD51 deubiquitination, thereby improving repair. Importantly, embryos somatic cell nuclear transfer (SCNT) exhibited defective...
// Zhenyu Bao 1, * , Weitao Zhang 2, Dong 1 Shanghai Key Laboratory of Regulatory Biology, Institute Biomedical Sciences, School Life East China Normal University, Shanghai, 2 Urology Surgery Department, Affiliated Hospital Taishan Medical Shandong, These authors have contributed equally to this work Correspondence to: Dong, email: ddong.ecnu@gmail.com Keywords: long non-coding RNA, prognosis, bladder urothelial carcinoma Received: October 15, 2016     Accepted: December...
Isoliquiritigenin (ISO) is a flavonoid extracted from the root of licorice, which serves various biological and pharmacological functions including antiinflammatory, antioxidation, liver protection, heart protection. However, mechanism its action remains elusive direct target proteins ISO have not been identified so far. Through cell‐based screening, we as potent lipid‐lowering compound. treatment successfully ameliorated fatty acid‐induced cellular lipid accumulation improved nonalcoholic...
We propose a two-dimensional model of biochemical activation process, whereby self-propelling particles finite correlation times are injected at the center circular cavity with constant rate equal to inverse their lifetime; is triggered when one such particle hits receptor on boundary, modeled as narrow pore. numerically investigated this process by computing mean-first exit through pore function and injection time constants. Due breach symmetry associated positioning receptor, may depend...
Abstract The kidney maintains homeostasis through an array of parallel nephrons, which all originate in development as isolated epithelial structures that later fuse their distal poles to a system collecting ducts (CD). This connection is required generate functional nephrons by providing pathway for excretion metabolic waste and byproducts. Currently, methods differentiating human pluripotent stem cells into organoids lack CDs instead terminate blind-ended tubules. Here we describe...
ABSTRACT The East Asian summer monsoon (EASM) exhibits significant decadal variations and influences the rainfall in China, which has a great impact on economic social activities there. Thus, accurate prediction of EASM important scientific significance application value. One key factors affecting skills is initialization, incorporates observed internal variability into initial condition (IC). However, few studies have pointed out importance ocean initialization improving skill. This study...
The objective of the present study was to clarify expression characteristics long non‑coding RNA (lncRNA) FGD5 antisense 1 (FGD5‑AS1) in pancreatic cancer, as well its biological function and underlying mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) utilized for detection FGD5‑AS1 microRNA (miR)‑577 levels cancer tissues. Transfection performed upregulate or downregulate cell lines. MTT Transwell assays were then detect proliferation, migration invasion...
Renal fibrosis is the inevitable outcome of all progressive chronic kidney diseases (CKD) and leads to a gradual loss renal function. We previously reported cyclic helix B peptide (CHBP), novel synthesized derived from erythropoietin, had shown effective renoprotection. In this study, we investigated anti-fibrotic renoprotective effect CHBP in murine tubulointerstitial model induced by unilateral ureter obstruction (UUO).Mice were subjected UUO was given intraperitoneally. To assess...
Objective Aberrant activation of Wnt/β-catenin signaling contributes to the maintenance cancer stem cells and chemoresistance in colorectal (CRC). Retinoic acid-induced 2 (RAI2) was proved be a tumor suppressor CRC our previous report. In this study, role RAI2 further investigated. Methods As transcriptional co-regulator, C-terminal Binding Protein (CtBP2) reported involved Wnt multiple complex ways. The correlation CtBP2 analyzed by TCGA dataset, interaction between explored...
BACKGROUND Non-ulcerative necrosis of the stomach and duodenum is rare because abundant blood supply in gastrointestinal tract. Duodenal a complication severe acute pancreatitis. Emergency pancreaticoduodenectomy (EPD) procedure, with extensive duodenal being one its indications. CASE SUMMARY We here report case 57-year-old man who survived EPD for pancreatitis, which resulted distal stomach, full-length duodenum, part jejunum. CONCLUSION Despite significant surgical risks, an could be...
Rectal cancer robotic surgery is becoming more and common, but evidence for predicting surgical difficulty scarce. Our goal was to look at the elements that influence complexity of robot-assisted total mesorectal excision (R-TME) in medical care middle low rectal as well establish validate a predictive model on basis these factors. Within this multicenter retrospective investigation, 166 consecutive patients receiving R-TME between January 2021 December 2022 with were included categorized...
In the study organic-inorganic hybrid composite, epoxy modified silicone coating and vinyl ester flake mastic were comparatively used as several anti-corrosion materials that provided protection for flue gas desulfu-rization (FGD). The relationship between curing conversion rate of polymer temperature was investigated by differential scanning calorimeter (DSC). adhesion strength, coefficient thermal expansion flame retardant properties three measured analyzed. A corrosion test in 8% H2SO4 5%...
Gene promoter methylation is a major epigenetic change in cancers, which plays critical roles carcinogenesis. As crucial regulator the early stages of B-cell differentiation and embryonic neurodevelopment, paired box 5 (PAX5) gene downregulated by several kinds tumors role this downregulation esophageal squamous cell carcinoma (ESCC) pathogenesis remains unclear.To elucidate PAX5 ESCC, eight ESCC lines, 51 primary tissue samples, normal mucosa samples were studied The Cancer Genome Atlas...
Elucidating the stability and morphology of bicellar mixtures is great importance in biomedical field. In this report, self-assembly cholesterol (CHOL)-containing were investigated, that composed long chain hydrogenated soybean phospholipids (HSPC), short 1, 2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC) phospholipids, negatively charged dipalmitoyl phosphatidylglycerol (1, 2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPG), polyethylene glycol conjugated...
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis GSDME-sufficient cells. The high GSDME expression and resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed light on another attractive strategy for PDAC treatment by promoting pyroptosis. Here we report a hGLuc-hGSDME-PCA system high-throughput screening potential activators against PDAC. This neatly quantifies the oligomerization GSDME-N characterize whether...