A5056156602- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Migraine and Headache Studies
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Optic Conditions
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Trigeminal Neuralgia and Treatments
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Cardiac Imaging and Diagnostics
- Sympathectomy and Hyperhidrosis Treatments
- Neurological Complications and Syndromes
- Cardiovascular Health and Disease Prevention
- interferon and immune responses
- NF-κB Signaling Pathways
- Cerebrovascular and genetic disorders
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Bone Metabolism and Diseases
- Musculoskeletal pain and rehabilitation
- Neurosurgical Procedures and Complications
- Facial Nerve Paralysis Treatment and Research
- Cervical and Thoracic Myelopathy
Massachusetts Eye and Ear Infirmary
2023-2025
Harvard University
2023-2025
University of Washington
2024-2025
Walgreens (United States)
2024
University of Massachusetts Amherst
2021
New England Retina Associates
2021
Eulji University Hospital
2016-2017
Eulji University
2005-2016
Samsung Medical Center
2016
Sungkyunkwan University
2016
Objectives To report demographics and characteristics of reversible cerebral vasoconstriction syndrome (RCVS) in the Korean cohort. Methods We prospectively recruited patients with definite (imaging-proven) RCVS probable (imaging-negative) who visited Samsung Medical Center between June 2012 September 2016. Clinical manifestations, neuroimaging, treatment, clinical outcomes were evaluated all patients. Characteristics without typical causes (“idiopathic RCVS”) compared those identifiable...
Purpose: We investigated the association between inner choroid flow deficit percentage (IC-FD%) using swept-source optical coherence tomography angiography (SS-OCTA) and progression of AMD. Methods: Retrospective, observational study including 64 eyes (42 participants) with early or intermediate AMD at baseline. Participants had two more consecutive covering a period least 18 months. Demographics, visual acuity, staging based on Beckman classification were reviewed. OCT was analyzed for...
We sought to establish normative quantitative contrast sensitivity function (qCSF) values in healthy adult eyes and investigate the effect of age on qCSF.
Caffeine has both excitatory and vasoconstrictive effects on central nervous system. use might be associated with development chronification of migraine. We aimed to evaluate the effect caffeine cessation acute treatment prospectively recruited migraine patients who consumed drinks daily instructed them discontinue their intake. Triptans were prescribed for treatment. Patients followed up after at least two weeks screening evaluated efficacy assessment current therapy (Migraine-ACT)...
Background and Objective The utility of incomplete retinal pigment epithelium (RPE) outer atrophy (iRORA) in intermediate age-related macular degeneration (iAMD) as a clinical endpoint is not yet elucidated. We aim to understand the time iRORA development iAMD. Patients Methods Eyes with iAMD without subjects fellow-eye neovascular AMD (nAMD) were identified from visits between 2010 2019 at tertiary clinic. Spectral Domain Optical Coherence Tomography 512 × 128mm cubes (Cirrus HD-OCT, Zeiss)...
Background/aims To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD). Methods This is part of a prospective longitudinal study that included patients with nAMD who have undergone three loading anti-VEGF injections. All underwent ophthalmological examinations including spectral domain optical coherence...
Best-corrected visual acuity (BCVA) is the current gold standard of retinal function measurement but not affected in early and intermediate forms age-related macular degeneration (AMD). Increasing evidence suggests that microperimetry a sensitive measure function. This study sought to analyze associations between plasma urine metabolites AMD. We included data on 363 eyes (95 controls, 268 AMD). Microperimetry was performed patients with or without AMD using Macular Integrity Assessment...
Abstract Objective Brain infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6J mice produces an etiologically relevant model of acquired seizures. Dietary changes can modify seizure presentation following TMEV brain and influence intestinal microbiome diversity composition. Intestinal dysbiosis may thus similarly affect burden antiseizure medicine (ASM) activity this model, independent pharmacokinetic effects. We sought to define the antibiotic (ABX)‐induced gut on acute...
Background Intracranial structural dislocation in spontaneous intracranial hypotension (SIH) can be measured by various angles and distances. We aimed to identify the clinical significance of relation treatment outcome patients with SIH. Methods In this retrospective analysis, we identified SIH who received an epidural blood patch (EBP) at Samsung Medical Center from January 2005 March 2015. Structural pretreatment MRIs was assessed measuring tonsillar herniation, mamillopontine distance,...
The clinical features and disease courses of primary stabbing headache (PSH) are diverse. We aimed to identify distinct patterns PSH.We prospectively screened consecutive first-visit patients who presented with at the Samsung Medical Centre Headache Clinic from June 2015 March 2016. Demographics, characteristics, were evaluated. After discerning factors related chronicity time presentation, identified based on frequency (daily vs. intermittent), course (remitted or not), total duration (<3...
Objective To assess longitudinal changes in cerebral blood flow velocities (ΔCBFVs) according to the clinical course of migraine. Methods We retrospectively included migraine patients with two or more attacks per month at baseline who were followed up within 2 years transcranial Doppler a tertiary headache clinic. ΔCBFVs analyzed relation courses, defined as remission (0–1 days/month), persistence (2–14/month), progression (≥15/month) episodic (EM), and conversion EM (<15/month) chronic...
The induction of interleukin-6 (IL-6) using a proinflammatory cytokine (IL-1β) was studied in human gingival fibroblasts (HGFs) relation to p38 MAPK and NF-κB transcription factor. When added HGFs, IL-1β had stimulatory effect on the production IL-6, this significantly reduced by SB203580, specific inhibitor. In addition, stimulation IL-6 release also addition pyrrolidine dithiocarbamate or SN50, which has been reported as potent Both inhibitors presence SB203580 more inhibitory release....
Objectives To serially test the International Classification of Headache Disorders (ICHD) 3rd edition beta version criteria for 6.7.3.1 probable reversible cerebral vasoconstriction syndrome (probable RCVS) in patients with thunderclap headache. Methods We prospectively screened consecutive headache who visited Samsung Medical Center between October 2015 and March 2017. Patients were included analysis if they a) our hospital within 1 month after onset, b) completed a diagnostic work-up, c)...
It has been reported that some patients with lacunar infarction have transient ischemic attacks (TIAs) before stroke. This study was aimed at evaluating the factors and prognostic value related to TIAs preceding acute stroke.A total of 1,424 were admitted hospital for first-ever Of which 314 enrolled this study. The divided into 2 groups based on occurrence stroke.Fifty-eight (18.5%) had a history TIAs. interval between TIA stroke less than 24 h in most (87.9%). Diabetes mellitus more often...
Purpose: To longitudinally investigate the changes in intraretinal microvascular abnormalities (IRMAs) over time, employing swept-source optical coherence tomography angiography eyes with diabetic retinopathy. Methods: In this retrospective, longitudinal study, we evaluated 12 × 12-mm centered on macula at baseline and last available follow-up visit for (1) IRMA during follow-up, defined as (a) stable, (b) regressed, (c) obliterated, (d) progressed; (2) development of new neovascularization...
To investigate whether there is visual function impairment in patients with posterior vitreous detachment (PVD) using the active-learning quantitative contrast sensitivity test.
In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect PHEs was studied. trabecular bone area thickness in OVX rats decreased by 50% from those sham-operated rats; these decreases were completely inhibited administration 7 weeks. Osteoclast numbers osteoblast surface enhanced rats, but had no on phenomena. Serum phosphorus alkaline phosphatase increased compared to increases not affected PHEs. Thyroxine...
Concurrent coronary artery disease (CAD) and carotid stenosis (CAS) are frequently detected in clinical practice have important prognostic implications symptomatic patients who considered for revascularization. The aim of this study was to assess the frequency asymptomatic CAD stroke with CAS associated factors.Coronary angiography performed at a single session after cerebral CAS, which candidate revascularization.Ninety-six were enrolled. We significant (defined as degree ≥50%)...
We sought to evaluate widefield swept-source optical coherence tomography angiography (WF SS-OCTA) among eyes with concomitant age-related macular degeneration (AMD) and diabetes mellitus or diabetic retinopathy (DM/DR).
Background and Objective: Our objective was to assess baseline widefield swept-source optical coherence tomography angiography (WF SSOCTA) microvascular metrics as predictors for the number of anti-vascular endothelial growth factor (VEGF) injections visual acuity (VA) at 12-months follow-up in patients with retinal vein occlusion (RVO). Patients Methods: This a prospective study including 49 RVO eyes from who had not received an anti-VEGF injection least 3 months prior imaging....