A5084317605- Nuclear Structure and Function
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Biotin and Related Studies
- Ubiquitin and proteasome pathways
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Diatoms and Algae Research
- Vestibular and auditory disorders
- Connexins and lens biology
- Hearing, Cochlea, Tinnitus, Genetics
- Renal and related cancers
University of Alberta
2022-2024
Arkana Laboratories
2020-2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2021
ABSTRACT Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of segment are microvilli-like calyceal processes (CPs). Although CP disruption has been associated altered morphology and photoreceptor degeneration, role CPs remains elusive. Here, we used zebrafish as model to characterize CPs. We quantified parameters report strong disparity in coverage between subtypes. length stable...
The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC. In rat cardiomyocytes, anchors proteins through its spectrin repeats, acting an adaptor between nesprin-1α and Pcnt or AKAP9. addition, AKAP9 form a protein platform tethering Golgi nucleus. Both exhibit MTOC activity utilizing either AKAP9, Pcnt-AKAP9, respectively. also required for...
Non-centrosomal microtubule-organizing centers (MTOCs) are pivotal for the function of multiple cell types, but processes initiating their formation unknown. Here, we find that transcription factor myogenin is required in murine myoblasts localization MTOC proteins to nuclear envelope. Moreover, sufficient fibroblasts envelope (NE-MTOC) and centrosome attenuation. Bioinformatics combined with loss- gain-of-function experiments identified induction AKAP6 expression as one central mechanism...
ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping researchers promote themselves alongside their papers. Maria Sharkova author on ‘ Photoreceptor calyceal processes accompany developing outer segment, adopting stable length despite dynamic core’, JCS. PhD student lab Dr Jennifer Hocking at Department Biology, University Alberta, Edmonton, Canada, investigating role microvilli surrounding sensory ending...
Abstract Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of segment are microvilli-like calyceal processes (CPs). While CP disruption has been associated altered morphology and photoreceptor degeneration, role remains elusive. Here, we used zebrafish as model to characterize CPs. We quantified parameters report strong disparity in coverage between subtypes. length stable across...
Abstract Non-centrosomal microtubule organizing centers (MTOC) are pivotal for the function of multiple cell types, but processes initiating their formation unknown. Here, we find that transcription factor myogenin is required in myoblasts localization MTOC proteins to nuclear envelope. Moreover, sufficient fibroblasts envelope (NE-MTOC) and centrosome attenuation. Bioinformatics combined with loss- gain-of-function experiments identified induction AKAP6 expression as one central mechanism...