A5101512285- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Mass Spectrometry Techniques and Applications
- Neuroscience and Neural Engineering
- Alzheimer's disease research and treatments
- Graphene and Nanomaterials Applications
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Chemokine receptors and signaling
- Gout, Hyperuricemia, Uric Acid
- Wound Healing and Treatments
- Cold Atom Physics and Bose-Einstein Condensates
- TGF-β signaling in diseases
- Traumatic Brain Injury Research
- Atomic and Subatomic Physics Research
- Trace Elements in Health
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Microplastics and Plastic Pollution
- Down syndrome and intellectual disability research
- T-cell and B-cell Immunology
- Neurogenesis and neuroplasticity mechanisms
- Advanced Proteomics Techniques and Applications
Nanjing Medical University
2020-2024
Jiangsu Province Hospital
2022-2024
Zhongda Hospital Southeast University
2024
People’s University
2022
Southeast University
2022
State Key Laboratory of Digital Medical Engineering
2022
State Key Laboratory of Reproductive Medicine
2021
Down syndrome (DS), caused by trisomy of chromosome 21, occurs in 1 every 800 live births. Early defects cortical development likely account for the cognitive impairments DS, although underlying molecular mechanism remains elusive. Here, we performed histological assays and unbiased single-cell RNA-Seq (scRNA-Seq) analysis on cerebral organoids derived from 4 euploid cell lines induced pluripotent stem cells (iPSCs) 3 individuals with 21 to explore cell-type–specific abnormalities associated...
Brain organoids are widely used to model brain development and diseases. However, a major challenge in their application is the insufficient supply of oxygen nutrients core region, restricting size maturation organoids. In order vascularize enhance nutritional areas, two-photon polymerization (TPP) 3D printing employed fabricate high-resolution meshed vessels this study. These made photoresist with densely distributed micropores diameter 20 μm on sidewall, cocultured facilitate diffusion...
Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this remain poorly understood. In report, we demonstrate that accumulation of damaged mitochondria, resulting from impaired mitphagy, plays significant role causing synaptic damage. Moreover, copper induced downregulation BNIP3 key player regulating mitophagy. DMSA alleviates and mitochondrial dysfunction by promoting urinary excretion copper. Mechanistically, find downregulate...
ABSTRACT The developing human foetal brain is sensitive to thermal stimulation during pregnancy. However, the mechanisms by which heat exposure affects development remain unclear, largely due lack of appropriate research models for studying stimulation. To address this, we have developed a periodic heating model based on organoids derived from pluripotent stem cells. recapitulated neurodevelopmental disruptions under prenatal at early stages, providing paradigm altered neurodevelopment...
Chemokine receptor CXCR5-mediated control of B cell trafficking in the lymphoid tissues plays a central role orchestrating function, which not only guides colocalization cells with follicular helper T mantle zone but also determines position germinal center dark and light zones. However, mechanisms that regulate expression CXCR5 remain unclear. Here, we show level was substantially reduced vitro culture conditions, while being maintained presence CD40 signals. Furthermore, signaling promotes...
We report the generation, trapping and sympathetic cooling of individual conformers molecular ions with example cis- trans-meta-aminostyrene. Following conformationally selective photoionization, incorporation into a Coulomb crystal laser-cooled calcium was confirmed by fluorescence imaging, mass spectrometry dynamics simulations. deduce molecules to be stable in trap environment for more than ten minutes. The present results pave way spectroscopy controlled chemistry distinct ionic traps.
Abstract Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. In this study, DA inhibits neural death induced by TBI or stretch injury, which is mediated via receptor D1 (DRD1). Our results showed that DRD1 signaling promotes interacting protein kinase 1 (RIPK1) ubiquitination E3 ubiquitin ligase Chip degradation through autophagy. Importantly, in vivo...
目的 比较非布司他与别嘌醇治疗痛风合并高尿酸血症的临床疗效及不良反应。 方法 选择青岛市西海岸新区中医医院肾病科和黑龙江省中医药科学院男科2015年10月至2017年10月治疗的痛风合并高尿酸血症患者80例为研究对象，采用随机数字表法分为治疗组40例和对照组40例。治疗组给予非布司他80 mg口服，每天1次；对照组给予别嘌醇100 mg口服，每天3次；疗程均为20周。观察两组的临床治疗效果、治疗前后血尿酸水平变化及不良反应发生情况。 结果 治疗组总有效率为95.0%，明显高于对照组的80.0%(χ2＝4.11，P<0.05)；治疗组治疗后血尿酸为(316.64±26.21)μmol/L，对照组为(348.45±20.16)μmol/L，两组差异有统计学意义(t＝3.420，P<0.05)；治疗组不良反应率为22.5%，明显低于对照组的45.0%(χ2＝4.52，P<0.05)。 结论 非布司他治疗痛风合并高尿酸血症临床疗效显著优于别嘌醇，且能有效改善患者血尿酸水平，不良反应少，安全性高。