A5030522293- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Radiopharmaceutical Chemistry and Applications
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Gallbladder and Bile Duct Disorders
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Urinary Bladder and Prostate Research
- Esophageal and GI Pathology
- Abdominal vascular conditions and treatments
- Cancer-related gene regulation
- Iterative Learning Control Systems
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Sexual function and dysfunction studies
- Tissue Engineering and Regenerative Medicine
- Optical measurement and interference techniques
- 3D Printing in Biomedical Research
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
Zhejiang University
2019-2023
First Affiliated Hospital Zhejiang University
2020-2023
Huazhong University of Science and Technology
2017-2023
Tongji Hospital
2017-2023
Dalian University of Technology
2019
Background:The programmed death 1 (PD1)/programmed ligand (PDL1) targeted therapies have gained positive outcomes in several tumors, but the evidence of expression and prognosis value PD1/PDL1 high risk prostate cancer was rare.Methods: Immunohistochemical analysis PDL1/PD1 by a validated antibody performed retrospectively collected cohort who received adjuvant hormonal therapy (AHT) after radical prostatectomy (RP).The association between determined.Results: In total, 127 patients were...
Dysregulation of transcription factors contributes to the carcinogenesis and progression cancers. However, their roles in clear cell renal carcinoma remain largely unknown. This study aimed evaluate clinical significance TFs investigate potential molecular mechanisms ccRCC. Data were accessed from cancer genome atlas kidney cohort. Bioinformatics algorithm was used copy number alterations mutations, differentially expressed TFs’ analysis. Univariate multivariate Cox regression analyses...
Although studies have showed that synthetic hydrogels the potential to be used in tissue engineering, rapid three-dimensional (3D) molding of with good biocompatibility is still a major challenge for researchers. In this paper, 2-hydroxyethyl methacrylate as hydrophilic monomer cured visible light. Combined natural gel network sodium alginate form composite hydrogel, mechanical properties, equilibrium water content, and cytotoxicity hydrogel were studied, 3D printing was attempted. Then,...
Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation these enzymes affects gene expression, which may lead to tumorigenesis. Here, we performed an integrated analysis 50 HMTs in bladder cancer and found intrinsic links between copy number alterations, mutations, expression levels, clinical outcomes. Through integrative analysis, identified six HMT genes (PRDM9,ASH1L,SETD3,SETD5,WHSC1L1, KMT2D) that play key role the development progression...
This study aimed to evaluate the efficacy of thickened condoms in treatment premature ejaculation.From August December 2021, patients with ejaculation treated Urology and Andrology Center First Affiliated Hospital Medical College Zhejiang University were selected for a clinical controlled study. A total 100 enrolled as group 30 normal men control (normal married men, age <30 years, sexual life). Each patient's latency, contraceptive safety, comfort, glans sensitivity, dorsal nerve conduction...
<b><i>Purpose:</i></b> To describe characteristics of pure small cell carcinoma prostate (SCCP) and assess the prognostic factors. <b><i>Patients Methods:</i></b> We summarized data SCCP from published studies ours made Kaplan-Meier analysis Cox regression to evaluate prognosis <b><i>Results:</i></b> A total 2,213 patients with cancer was identified, which eight (0.36%) were SCCP. The mean age at diagnosis 61 years old....
Purpose The purpose of this paper is to design an automatic press-fit instrument realize precision assembly and connection quality assessment a small interference fitting parts, armature. Design/methodology/approach In paper, was developed for the technical problems reliable clamping positioning armature, measurement adjustment attitude evaluation quality. To compensate installation error equipment, corresponding calibration method proposed each module instrument. Assembly strategies axial...
SET domain-containing 2 (SETD2) is the most frequently mutated gene among all histone methyltransferases in clear cell renal carcinoma (ccRCC). Microarrays, RNA sequencing analysis and exosomes of cellular supernatant were performed after transfection A498 cells with si-SETD2 or siRNA negative control. Chromatin immunoprecipitation Luciferase reporter assay conducted to evaluate interaction between SETD2 miR-10b. Functional drug experiments vitro vivo verify role SETD2, miR-10b MAP4K4. The...
The current study presents a case of primary prostatic extra-gastrointestinal stromal tumor (EGIST) in 43-year-old man who suffered acute urinary retention. serum level prostate-specific antigen was normal. Imaging examinations demonstrated diffusely enlarged prostate compressing the rectum without evidence metastasis. After excluding possibility secondary involvement by rectal GIST, pathologic diagnosis EGIST established based on microscopic study, immunohistochemistry, and molecular...
Abstract Background The outcomes of large‐sized graft mismatch in deceased donor liver transplantation (LT) have been rarely studied. aim this study was to determine whether a for recipient influenced the post‐transplant outcomes. Methods A total 273 patients undergoing LT were enrolled and divided into large normal‐sized group by weight (GWRW) >2.5% ( n = 76) or GWRW ≤2.5% 197). Post‐operative complications retrospectively analysed. Results two groups comparable demographic...
Currently, the association between prostate volume (PV) or weight with pathological outcomes in patients cancer (PCa) is not well understood. This study aimed to explore whether PV can predict adverse of PCa after radical prostatectomy (RP). A total 1063 men confirmed localized who underwent RP at First Affiliated Hospital Zhejiang University from January 2014 April 2019 were retrospectively analyzed. Patients assigned into small, medium and large groups based on PV. The analysis variance,...
Objective To evaluate the prognostic value of ratio AR and AR-V7 expression in prostate cancer treated by castration therapy. Methods Immunohistochemical staining was performed biopsy specimen 136 patients received hormone therapy Tongji Hospital Huazhong University Science Technology from January 2010 to December 2015. Expression determined using modified H score method. Patients aged 53-96, median age 71, tPSA at diagnosed 110.00 ng/ml(2.61-4 003.4 ng/ml), fPSA 14.62...
Androgen receptor splice variant 7 (AR-V7) is one of the androgen variants, which highly expressed in castration-resistant prostate cancer tissues. Recent studies have showed that AR-V7 mechanisms progression with resistance second generation hormonal therapy. Consequently, as a potential therapeutic target for cancer, upstream regulation has become new research hotspot. Current researches show expression level and transcriptional activity are regulated by transcription factors,...