A5072703222- Effects of Radiation Exposure
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Radiation Effects and Dosimetry
- Virus-based gene therapy research
- Radiation Therapy and Dosimetry
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Extracellular vesicles in disease
- Competitive and Knowledge Intelligence
- Nonmelanoma Skin Cancer Studies
- Cancer-related molecular mechanisms research
- Electron Spin Resonance Studies
- Cancer Immunotherapy and Biomarkers
- Cancer and Skin Lesions
- Cell Image Analysis Techniques
- Proteoglycans and glycosaminoglycans research
- Knowledge Management and Sharing
- Telomeres, Telomerase, and Senescence
- Biological Research and Disease Studies
- Genetic factors in colorectal cancer
- Respiratory and Cough-Related Research
- Colorectal Cancer Surgical Treatments
- Polyomavirus and related diseases
Victorian Comprehensive Cancer Centre
2020-2022
The University of Melbourne
2015-2022
University of Cape Town
2007-2022
Peter MacCallum Cancer Centre
1996-2016
University of California, Davis
1993
Los Alamos National Laboratory
1993
Purpose Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines these order identify clinical predictors toxicity. Experimental Design In 12 NSCLC patients, 60 Gy (30 fractions over 6 weeks) was delivered; received concurrent chemoradiation (chemoRT) and alone. Blood samples were taken before therapy, at 1 24 hours delivery 1st fraction, 4...
Abstract Purpose: To study the response of irradiated and out-of-field normal tissues during localized curative intent radiotherapy. Experimental Design: Sixteen patients with non–small cell lung carcinoma (NSCLC) received 60 Gy in 30 fractions definitive thoracic radiotherapy or without concurrent chemotherapy. Peripheral blood lymphocytes (PBL) eyebrow hairs were sampled prior, during, after Clinical variables dose/volume, patient age, use chemoradiotherapy tested for association γ-H2AX...
To determine the antitumor activity and toxicity of paclitaxel administered as a 3-hour infusion in patients with advanced non-small-cell lung cancer (NSCLC).Fifty-one measurable or assessable NSCLC performance status 0 to 2 who had not received prior chemotherapy were treated 175 mg/m2 over 3 hours premedication. Cycles repeated every weeks for maximum nine cycles. Most radiotherapy (57%), extrathoracic metastatic disease (65%), (75%). Twenty-two percent previously untreated stage III...
We have examined whether dissociation of the histone octamer is required for elongation RNA transcripts through arrays nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-base-pair (bp) 5S rDNA positioning sequences inserted between T7 and SP6 transcription promoters pGEM-3Z. Double label experiments showed that there was little no effect extensive crosslinking...
The author adopts the premise that effective communication of scientific and technological information is pivotal to success innovation sustained economic growth this applies particularly South Africa. Many factors are, however, currently impacting on process, not least which are burgeoning industry, globalization, rapid advances. This factor motivated investigate impact electronic modes article based research project. community scientists engaged in crystallographic Africa was selected as...
It is contended that disaster management and planning should be one of the most important aspects library management, but in practice it has been found to a neglected field librarianship, particularly South Africa. This article explores main issues reports on study investigated research, academic public libraries Greater Cape Metropolitan Area. was majority were lacking formal plans generally under-prepared for any potential disasters which may occur. attributed inadequate resources also...
Geno- and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance tumour recurrence. However, due to the technical difficulty associated with studying such intra-tumoural heterogeneity, this phenomenon is seldom interrogated in conventional culture models. Here, we employ a fluorescent lineage technique termed "optical barcoding" (OBC) perform simultaneous longitudinal tracking spatio-temporal fate 64 patient-derived colorectal subclones....
Purpose: The objective of the study was to conjugate DNA binding ligand para-[125I]-iodoHoechst octreotate, and explore tumour targeting potential this in octreotate-somatostatin receptor system.Methods: We synthesized a Hoechst analogue containing tri-butylstannyl group para position phenyl ring, conjugated it N-terminal amino octreotate prepared 125I-labelled by iododestannylation. used somatostatin (SSTR2) over-expressing cell line A427-7 derived from its parent A427 human non-small lung...
ABSTRACT Patients with colorectal cancer (CRC) frequently develop liver metastases during the course of their disease. A substantial proportion them receive neoadjuvant FOLFOX (5-Fluorouracil, Oxaliplatin, Leucovorin) prior to surgery in an attempt enable successful surgical removal and reduce risk recurrence. Yet, majority patients progress treatment or recur following surgery, molecular mechanisms that contribute resistance remain poorly understood. Here, using a combination phenotypic,...
Circulating tumor cells (CTCs) are promising diagnostic and prognostic tools for clinical use. In several cancers, including colorectal breast, the CTC load has been associated with a therapeutic response as well progression-free overall survival. However, counting isolating CTCs remains sub-optimal because they currently largely identified by epithelial markers such EpCAM. New, complementary surface therefore urgently needed. We previously demonstrated that splice variant of CD44, CD44...
Suspected adverse reactions (SARs) reported for Cartrophen Vet (100 mg sodium pentosan polysulphate/ml) to the Veterinary Medicines Directorate in UK period January 1991 October 1999 were reviewed. Of 161 reports, 28 probably product related, 54 possibly 71 unlikely be related and eight unclassified. An estimated real incidence of associated with 0·074 per cent on an individual dose basis was calculated (assuming only 10 documented due underreporting). Sixty‐two SARs (38·5 cent) emesis, 22...
The effect of the work environment on communication information in science is examined. main characteristics that distinguish and conceptual issues pertain to process are circumscribed. article further based data derived from an empirical study investigated among crystallographers South Africa. conducted research one three environments: universities, or institutes, R&D facilities industry. results strongly indicate each predicated distinct behaviour patterns. Each group interacted...
Abstract Thousands of patients die annually with distant metastasis after curative-intent or “radical” radiation therapy (RT). Because non-small cell lung cancer (NSCLC), the most common cause cancer-related mortality, exhibits an especially high rate radical RT chemo-RT for locoregionally-advanced disease, it represents a suitable model to investigate relationship between and metastasis. We hypothesized that disruption tumour architecture during could result in release viable tumor cells...
<p>Association between PTV volume and excess (above the baseline) average number of foci per cell (a) proportion cells with {greater than or equal to} 6 γ-H2AX (b) at 1-hour 24-hours.</p>