Patrick E. Burnett

ORCID: 0009-0000-2103-7185
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About
Contact & Profiles
Research Areas
  • Signaling Pathways in Disease
  • Cellular transport and secretion
  • Autoimmune Bullous Skin Diseases
  • Lipid Membrane Structure and Behavior
  • DNA Repair Mechanisms
  • Uterine Myomas and Treatments
  • Wnt/β-catenin signaling in development and cancer
  • Cardiac Structural Anomalies and Repair
  • Autoimmune and Inflammatory Disorders
  • Peptidase Inhibition and Analysis
  • Hippo pathway signaling and YAP/TAZ
  • Skin and Cellular Biology Research
  • Neurobiology and Insect Physiology Research
  • Oral Health Pathology and Treatment
  • Helicobacter pylori-related gastroenterology studies
  • Hidradenitis Suppurativa and Treatments
  • Insect Resistance and Genetics
  • Nerve injury and regeneration
  • Cancer-related Molecular Pathways
  • Calcium signaling and nucleotide metabolism
  • Cancer Diagnosis and Treatment
  • Nail Diseases and Treatments
  • PARP inhibition in cancer therapy
  • Chemotherapy-related skin toxicity
  • Cellular Mechanics and Interactions

Atara Biotherapeutics (United States)
2025

Memorial Sloan Kettering Cancer Center
2011

Pfizer (United States)
2011

Hospital São Lucas da PUCRS
2011

Institut Gustave Roussy
2011

Vanderbilt University
2008-2010

VA Tennessee Valley Healthcare System
2008

New York University
2003

Johns Hopkins Medicine
1998-2000

Johns Hopkins University
1998-2000

The complex of rapamycin with its intracellular receptor, FKBP12, interacts RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive target and a member ataxia telangiectasia mutated (ATM)-related family kinases that share homology catalytic domain phosphatidylinositol 3-kinase. function RAFT1 pathway connection to downstream components pathway, such as p70 S6 kinase 4E-BP1, are poorly understood. Here, we show directly phosphorylates S6k , 4E-BP2 serum stimulates activity kinetics similar those...

10.1073/pnas.95.4.1432 article EN Proceedings of the National Academy of Sciences 1998-02-17

Calcineurin is a widely distributed protein phosphatase regulated by calcium and calmodulin. It mediates the immunosuppressive actions of drugs such as cyclosporin FK506, has been implicated in number calcium-sensitive pathways nervous system, including regulation neurotransmitter release modulation long-term changes synaptic plasticity. associates physiologically with other proteins, calmodulin, FKBP12 (FK506-binding protein), ryanodine receptor, inositol 1,4,5-trisphosphate receptor. We...

10.1074/jbc.273.29.18325 article EN cc-by Journal of Biological Chemistry 1998-07-01

Epithelial-cadherin (E-cadherin) is a master organizer of the epithelial phenotype. Its function regulated in part by p120-catenin (referred to herein as p120), cytoplasmic binding partner that directly regulates cadherin stability. As it has been suggested cadherins have role inflammatory bowel disease (IBD), we sought investigate this further assessing effect p120 deficiency mouse small intestine and colon. conditional KO mice were superficially normal at birth but declined rapidly died...

10.1172/jci41414 article EN Journal of Clinical Investigation 2010-05-20

RAFT1 (rapamycin and FKBP12 target 1; also called FRAP or mTOR) is a member of the ATM (ataxia telangiectasia mutated)–related family proteins functions as in vivo mediator effects immunosuppressant rapamycin an important regulator messenger RNA translation. In mammalian cells interacted with gephyrin, widely expressed protein necessary for clustering glycine receptors at cell membrane neurons. mutants that could not associate gephyrin failed to signal downstream molecules, including p70...

10.1126/science.284.5417.1161 article EN Science 1999-05-14

Exocytosis of synaptic vesicles is calcium-dependent, with synaptotagmin serving as the calcium sensor. Endocytosis has also been postulated a calcium-dependent process; however, an endocytic sensor not found. We now report physical association between phosphatase calcineurin and dynamin 1, component machinery. The calcineurin-dynamin 1 interaction EC<sub>50</sub> for in range 0.1–0.4 μm. Disruption inhibits clathrin-mediated endocytosis. Thus, formation complex, delivered to other coat...

10.1074/jbc.274.37.25963 article EN cc-by Journal of Biological Chemistry 1999-09-01

p70 S6 kinase (p70 S6k ) is a mitogen-activated protein that plays central role in the control of mRNA translation. It physiologically phosphorylates 40s ribosomal subunit response to mitogenic stimuli and downstream component rapamycin-sensitive pathway, which includes 12-kDa FK506 binding rapamycin target 1. Here, we report identification neurabin (neural tissue-specific F-actin protein), neuronally enriched 1,095 amino acids contains PDZ domain binds . We demonstrate neurabin-p70...

10.1073/pnas.95.14.8351 article EN Proceedings of the National Academy of Sciences 1998-07-07

ABSTRACT Background Psoriasis occurring on the skin of genital and perigenital regions, including inguinal creases, vulva, penis, scrotum, perianal area, intergluteal cleft, has specific diagnostic treatment requirements due to sensitivity private nature these areas. Objectives A multidisciplinary group 13 US‐based clinicians who are experts in management psoriasis, Genital Wellness Consortium, convened discuss impact psoriasis patients focusing three main domains: (1) physical diagnosis...

10.1002/jvc2.70043 article EN cc-by JEADV Clinical Practice 2025-05-14

320 Background: HFS and related skin toxicities are common side effects of tyrosine kinase inhibitors such as SU, a multitargeted inhibitor VEGF PDGF receptors plus other receptor kinases. In randomized phase III trial treatment-naïve mRCC pts, SU showed superior progression-free survival (PFS) objective response rate (ORR) over interferon-alfa, with median PFS 11 mo overall (OS) 26.4 mo, establishing reference standard care (Motzer et al, 2009). this retrospective analysis, correlations...

10.1200/jco.2011.29.7_suppl.320 article EN Journal of Clinical Oncology 2011-03-01

A 53-year-old man with human-immunodeficiency-virus infection presents a 2-year history of nodules on the extensor surfaces his extremities. biopsy confirmed diagnosis erythema elevatum diutinum. The clinical presentation, histopathology, etiology, and treatment options are reviewed.

10.5070/d37b91t5fn article EN Dermatology Online Journal 2003-01-01

A 55-year-old man with psoriasis presented erythematous, edematous plaques, tense bullae, and erosions. Direct immunofluorescence histopathologic examination confirmed the diagnosis of bullous pemphigoid. Both dermatologic conditions responded to azathioprine. The clinical presentation, etiology, treatment options are reviewed.

10.5070/d37g85p6rf article EN Dermatology Online Journal 2003-01-01
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