A5054760469- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Oral microbiology and periodontitis research
- Peroxisome Proliferator-Activated Receptors
- Digestive system and related health
- Genomics and Phylogenetic Studies
- Click Chemistry and Applications
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Genomics and Chromatin Dynamics
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
Institut Pasteur
2019-2024
Centre National de la Recherche Scientifique
2013-2024
Université Paris Cité
2015-2024
Fondation de l'Avenir
2020
Inserm
2013-2020
Structure et Instabilité des Génomes
2015
Sorbonne Université
2015
Background: Gastric cancer (GC) is often associated with a poor prognosis, due to its asymptomatic early stages. The current gold standard for diagnosing GC, upper endoscopy, invasive and has limited sensitivity detecting gastric preneoplasia such as dysplasia. Non-invasive biomarkers, circulating proteins in the blood, hold promise detection of lesions. Methods: During an exploratory study, plasma samples from 39 participants, including patients diagnosed different pathologies (gastritis,...
DNA imaging in living cells usually requires transgenic approaches that modify the genome. Synthetic pyrrole-imidazole polyamides bind specifically to minor groove of double-stranded (dsDNA) represent an attractive approach for in-cell does not necessitate changes Nine hairpin target mouse major satellite were synthesized. Their interactions with synthetic dsDNA fragments studied by thermal denaturation, gel-shift electrophoresis, circular dichroism, and fluorescence spectroscopy. The had...
Abstract Lipoprotein modification is an essential process in Gram-negative bacteria. The action of three integral membrane proteins that catalyze the transfer fatty acids derived from phospholipids or cleave signal peptide lipoprotein substrate result formation mature triacylated proteins. Inactivation enzymes leads to mis-localization immature lipoproteins and consequently cell death. Biochemical studies development vitro assays are challenging due fact substrates all membrane-embedded...
Lipoproteins from proteobacteria are posttranslationally modified by fatty acids derived membrane phospholipids the action of three integral enzymes, resulting in triacylated proteins. The first step lipoprotein modification pathway involves transfer a diacylglyceryl group phosphatidylglycerol onto prolipoprotein, prolipoprotein. In second step, signal peptide prolipoprotein is cleaved, forming an apolipoprotein, which turn third acid phospholipid. This last catalyzed apolipoprotein...
Lipoproteins from proteobacteria are posttranslationally modified by fatty acids derived membrane phospholipids the action of three integral enzymes, resulting in triacylated proteins. The first step lipoprotein modification pathway involves transfer a diacylglyceryl group phosphatidylglycerol onto prolipoprotein, prolipoprotein. In second step, signal peptide prolipoprotein is cleaved, forming an apolipoprotein, which turn third acid phospholipid. This last catalyzed apolipoprotein...