A5082432760- Computational Drug Discovery Methods
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Nanoparticles: synthesis and applications
- Chemistry and Chemical Engineering
- Metabolomics and Mass Spectrometry Studies
- Effects and risks of endocrine disrupting chemicals
- Advanced Chemical Sensor Technologies
- Renal Diseases and Glomerulopathies
- Atmospheric chemistry and aerosols
- Renal cell carcinoma treatment
- Cholinesterase and Neurodegenerative Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Electrochemical Analysis and Applications
- Graphene research and applications
- Municipal Solid Waste Management
- Carbon and Quantum Dots Applications
- Microplastics and Plastic Pollution
- Water Quality Monitoring and Analysis
- Advanced Nanomaterials in Catalysis
- Chemical Reaction Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Invertebrate Immune Response Mechanisms
- Atmospheric Ozone and Climate
- Graphene and Nanomaterials Applications
Guangdong Academy of Sciences
2022-2025
Dalian University of Technology
2018-2024
UF Health Cancer Center
2024
University of Florida Health
2024
Shenzhen General Institute of Architectural Design and Research (China)
2024
Zhejiang University
2024
University of Florida
2024
Jining Medical University
2022-2023
Guangxi University
2023
Guangxi University of Chinese Medicine
2023
Iodic acid (IA) has recently been recognized as a key driver for new particle formation (NPF) in marine atmospheres. However, the knowledge of which atmospheric vapors can enhance IA-induced NPF remains limited. The unique halogen bond (XB)-forming capacity IA makes it difficult to evaluate enhancing potential (EP) target compounds on based widely studied sulfuric systems. Herein, we employed three-step procedure EP nucleation precursors NPF. First, evaluated 63 by simulating free energies...
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus that presents high risk end-stage renal disease. In the present study, we used CIBERSORT and gene set enrichment analysis (GSEA) expression profiles to identify immune cell infiltration characteristics related core genes in LN.Datasets from Gene Expression Omnibus, GSE32591 GSE113342, were downloaded for further analysis. The dataset, which included 32 LN glomerular biopsy tissues 14 living donors, was analyzed by...
Many phthalate esters (PAEs) are chemicals of high production volume and toxicological concern. The second-order rate constant for base-catalyzed hydrolysis (kB) is a key parameter assessing environmental persistence PAEs. However, the kB values most PAEs lacking, experimental determination encounters various difficulties. Herein, density functional theory (DFT) methods were selected by comparing empirical five carboxylic acid with DFT-calculated ones. Results indicate that cyclic side...
Machine learning (ML) models for screening endocrine-disrupting chemicals (EDCs), such as thyroid stimulating hormone receptor (TSHR) agonists, are essential sound management of chemicals. Previous TSHR agonists were built on imbalanced datasets and lacked applicability domain (AD) characterization regulatory application. Herein, an updated agonist dataset was built, which the ratio active to inactive compounds greatly increased 1:2.6, chemical spaces structure–activity landscapes (SALs)...
Parabens for which the molecules contain hydrolytic and ionizable groups, are emerging pollutants due to their ubiquity in environment. However, lack of pKa second-order base-catalyzed hydrolysis kinetics (kB) values limits environmental persistence assessment. Herein, six parabens were selected as reference compounds kB measured experimentally. A semiempirical quantum chemical (QC) method was calculate parabens, density functional theory (DFT) methods neutral anionic forms by comparing...
The extensive application of graphene nanosheets (GNSs) has raised concerns over risks to sensitive species in the aquatic environment. humic acid (HA) corona is traditionally considered reduce GNSs toxicity. Here, we evaluate effect sorbed HA (GNSs-HA) on toxicity Gram positive Bacillus tropicus. Contrary previous data, GNSs-HA exhibits greater compared GNSs. Multi-omics combined with bioassays and electrochemical methods reveals disrupt oxidative phosphorylation by causing physical...
Four quantitative structure–activity relationship (QSAR) models were developed for predicting the log <italic>K</italic> values of organic pollutants adsorbed onto boron nitride nanosheets in gaseous and aqueous environments.
Abstract Kidney renal clear cell carcinoma (KIRC) is a common tumor with poor prognosis and closely related to many aberrant gene expressions. DNA methylation an important epigenetic modification mechanism novel research target. Thus, exploring the relationship between methylation-driven genes KIRC important. The profile, genes, characteristics in was revealed through integration of methylation, RNA-seq, clinical information data from Cancer Genome Atlas. Lasso regression used establish...
Alternative splicing (AS) contributes to protein diversity by modifying most gene transcriptions. Cancer generation and progression are associated with specific events. However, AS signature in kidney renal clear cell carcinoma (KIRC) remains unknown. In this study, genome-wide profiles were generated 537 patients KIRC the cancer genome atlas. With a total of 42 522 mRNA events 10 600 genes acquired, 8164 significantly survival KIRC. Logistic regression analysis least absolute shrinkage...
Bacillus cereus is a well-characterized human pathogen that produces toxins associated with diarrheal and emetic foodborne diseases. To investigate the possible transmission of B. on lettuce farms in China determine its enterotoxicity, (I) total 524 samples (lettuce: 332, soil: 69, water: 57, manure: pesticide: 9) were collected from 46 five Chinese provinces, (II) multilocus sequence typing (MLST) was used to classify isolates for trace analysis, (III) presence toxin genes enterotoxins (Hbl...