A5038418447- Berberine and alkaloids research
- Advanced Photocatalysis Techniques
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Covalent Organic Framework Applications
- Neural dynamics and brain function
- Inflammatory Biomarkers in Disease Prognosis
- Traditional Chinese Medicine Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Carbon and Quantum Dots Applications
- Natural Antidiabetic Agents Studies
- MicroRNA in disease regulation
- Functional Brain Connectivity Studies
- Plant-based Medicinal Research
- Immune Response and Inflammation
- Phytochemistry and biological activities of Ficus species
- Occupational and environmental lung diseases
- Advanced Image Fusion Techniques
- Gout, Hyperuricemia, Uric Acid
- FOXO transcription factor regulation
- Cancer therapeutics and mechanisms
- Medicinal Plant Pharmacodynamics Research
- Acute Kidney Injury Research
- Circular RNAs in diseases
- Connective Tissue Growth Factor Research
Center for Life Sciences
2024
Tsinghua University
2024
Peking University
2024
Chengdu University of Traditional Chinese Medicine
2019-2024
Hodges University
2023
Jinan University
2016-2020
Guizhou Provincial People's Hospital
2018-2020
Weihai Municipal Hospital
2018
Zunyi Medical University
2013
Affiliated Hospital of Zunyi Medical College
2011
Abstract Background Sepsis-induced acute lung injury (ALI) is a clinical syndrome characterized by the of alveolar epithelium and pulmonary endothelial cells. This study aimed to investigate regulation long noncoding RNA (lncRNA) taurine up-regulated gene 1 (TUG1) in murine ALI model primary microvascular cells (PMVECs) stimulated with lipopolysaccharide (LPS). Methods Adult C57BL/6 mice were intravenously injected or without TUG1-expressiong adenoviral vector control week before...
Sea buckthorn ( Hippophae L.), a well-known medicinal and edible plant, is known as the “king of VC”.
The dried stem bark of Berberis vernae Schneid., known as "Xiao-bo-pi" in Chinese, is a representative anti-diabetic herb traditional Tibetan medical system. However, its mechanisms and active components remain unclear. In this study, 1H NMR-based metabolomics, biochemistry assay, molecular docking, network analysis were integrated to evaluate the effects B. extract on type 2 diabetic rats, explore underlying mechanisms. Diabetes was induced by high-fat diet streptozotocin. After 30 days...
The dried stem bark of Berberis kansuensis is a commonly used Tibetan herbal medicine for the treatment diabetes. Its main chemical components are alkaloids, such as berberine, magnoflorine and jatrorrhizine. However, role gut microbiota in vivo metabolism these has not been fully elucidated. In this study, an ultra-high performance liquid chromatography method coupled with Orbitrap mass spectrometry (UHPLC-Orbitrap-MS) technology was applied to detect identify prototype metabolites rat...
Wang Z (Institute of Industrial Health, Anshan Iron and Steel Corporation, #29, 219 Park Drive, Anshan, Liaoning, 114001, P R China), Dong D, bang X, Qu G, Wu J Xu X. Cancer mortality among silicotics in China's metallurgical industry.International Journal Epidemiology 1996; 25: 913–917. We conducted a retrospective cohort study lung cancer industries. The consisted 4372 male diagnosed alive before 1 January 1980. follow-up period was 1980 to 31 December 1989. Standardized ratios (SMR) all...
The multiplicative noise removal problem has received considerable attention recently. To solve this problem, various variational models have been proposed, which minimise an energy functional composed of the data term and regularisation term. Regarding term, a first‐order model is frequently used to remove noise, may cause staircase effect loss contrast in output image. In study, authors use second‐order model, total curvature (TC), above problem. TC benefit removing maintaining image...
Forkhead box N1 (FOXN1) belongs to the FOX family of transcription factors, which comprises a diverse group winged-helix proteins. FOXN1 is ubiquitously expressed member that has been implicated in embryo development, metabolism, aging and cancer. However, little known regarding role non-small cell lung cancer (NSCLC). The aim study was investigate function NSCLC examine relevant mechanism. In present study, using reverse transcription-quantitative polymerase chain reaction, western...
Abstract Ba‐Wei‐Long‐Zuan granule (BWLZ) is a traditional herbal preparation. It has been widely used for the treatment of rheumatoid arthritis (RA). However, its active ingredients and mechanisms action are still unclear. The present study aims to reveal compounds anti‐arthritic BWLZ against collagen‐induced (CIA) by using 1 H‐NMR‐based metabolomics, molecular docking network pharmacology methods. After 30 days administration, could effectively improve metabolic disorders in CIA rats....
Abstract The dried stem bark of Berberis kansuensis C.K. Schneid . (Berberidaceae) was widely used to treat diabetes in traditional Tibetan medicine system. However, its anti‐diabetic mechanisms have not been elucidated. In this study, 1 H‐NMR‐based metabolomics combined with biochemistry assay applied investigate the activities as well underlying B. extract on type 2 diabetic rats. results showed that after 30 days treatment extract, levels FBG, GSP, INS, TNF‐ α , IL‐1 β and IL‐6 were...
To elucidate the absorption and metabolism of alkaloids in Berberis kansuensis vivo, a high performance liquid chromatography-triple quadrupole mass spectrometry(HPLC-QqQ-MS) method was developed to qualitatively quantitatively analyze components rat serum multiple-reaction monitoring mode. The mobile phase consisted 0.1% formic acid acetonitrile with gradient elution In addition, investigate effects gut microbiota on five absorbed B. serum, diabetic pseudo germ-free models were established,...
Pneumonia disease is one of the leading causes death among children and adults worldwide. In last ten years, computer-aided pneumonia detection methods have been developed to improve efficiency accuracy diagnosis process. Among those methods, effects deep learning approaches surpassed that other traditional machine methods. This review paper searched examined existing mainstream deep-learning in regions. focuses on key aspects collected research, including their datasets, data processing...
The purpose of this study was to establish a parabiotic mice model and assess the physiological changes under state. Thirteen pairs isogenic partners were studied. created by preparing bridge skin subcutaneous tissues between two starting distal elbow joint along humerus lateral costal region until end waist line. Physiological, social affective qualities life studied in through behavioural observations for 120 days following surgery. During first 2-3 operation, animals suffered from severe...