A5101805032- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Satellite Communication Systems
- GNSS positioning and interference
- Calcium signaling and nucleotide metabolism
- Regional Economics and Spatial Analysis
- Geophysics and Gravity Measurements
- Geomechanics and Mining Engineering
- Ionosphere and magnetosphere dynamics
- Identification and Quantification in Food
- Cellular transport and secretion
- S100 Proteins and Annexins
- Reproductive tract infections research
- Kruppel-like factors research
- China's Socioeconomic Reforms and Governance
- Neuroscience and Neuropharmacology Research
- Environmental DNA in Biodiversity Studies
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- Geothermal Energy Systems and Applications
- Geoscience and Mining Technology
- Educational Technology and Pedagogy
- PARP inhibition in cancer therapy
Chinese Academy of Sciences
2010-2025
Shenzhen Institutes of Advanced Technology
2021-2025
Shaanxi Institute of Zoology
2023-2025
National Time Service Center
2013-2024
University of Chinese Academy of Sciences
2017-2024
Institute of Biophysics
2023-2024
Westlake University
2024
Yidu Central Hospital of Weifang
2024
Zhejiang Cancer Hospital
2022
Peking University
2017-2019
Abstract Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning integrity of blood-brain barrier (BBB). This manuscript delves into intricate relationship between obesity and BBB dysfunction, elucidating underlying phenotypes molecular mechanisms. We commence with an overview BBB’s critical role in maintaining cerebral homeostasis pathological alterations induced by obesity. By employing...
Abatract Background Neoadjuvant chemotherapy (NAC) can downstage tumors and axillary lymph nodes in breast cancer (BC) patients. However, response to NAC are not parallel vary among This study aims explore the feasibility of deep learning radiomics nomogram (DLRN) for independently predicting status node metastasis (LNM) after NAC. Methods In total, 484 BC patients who completed from two hospitals (H1: 297 training cohort 99 validation cohort; H2: 88 test cohort) were retrospectively...
Accurate and non-invasive diagnosis of pancreatic ductal adenocarcinoma (PDAC) chronic pancreatitis (CP) can avoid unnecessary puncture surgery. This study aimed to develop a deep learning radiomics (DLR) model based on contrast-enhanced ultrasound (CEUS) images assist radiologists in identifying PDAC CP.Patients with or CP were retrospectively enrolled from three hospitals. Detailed clinicopathological data collected for each patient. Diagnoses confirmed pathologically using biopsy surgery...
Ischemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application patient-specific factors. This review focuses early phase pathophysiological mechanisms ischemic nuances recanalization. It highlights dual role neutrophils in tissue damage repair, involvement...
cADPR is a well-recognized signaling molecule by modulating the RyRs, but considerable debate exists regarding whether can bind to and gate TRPM2 channel, which mediates oxidative stress in diverse physiological pathological processes. Here, we show that purified evoked channel currents both whole-cell cell-free single-channel recordings specific binding of NUDT9-H domain surface plasmon resonance. Furthermore, combining computational modeling with electrophysiological recordings, channels...
Disruption of the blood-brain barrier (BBB) causes or contributes to neuronal dysfunction and several central nervous system (CNS) disorders. Wnt/β-catenin signaling is essential for maintaining integrity adult BBB in physiological pathological conditions, including stroke. However, how impairment endothelial results breakdown remains unclear. Furthermore, individual contributions different permeability-inducing mechanisms, intercellular junction damage, transcytosis, fenestration,...
The blood-brain barrier (BBB) is a critical interface that maintains the central nervous system homeostasis by controlling exchange of substances between blood and brain. Disruption BBB plays vital role in development neuroinflammation neurological dysfunction sepsis, but mechanisms which becomes disrupted during sepsis are not well understood. Here, we induced endotoxemia, major type mice intraperitoneal injection lipopolysaccharide (LPS). LPS acutely increased permeability, activated...
CD38 catalyzes the synthesis of Ca2+ messenger, cyclic ADP-ribose (cADPR). It is generally considered to be a type II protein with catalytic domain facing outside. How it can catalyze intracellular cADPR that targets endoplasmic stores has not been resolved. We have proposed also exist in an opposite III orientation its cytosol. Here, we developed method using specific nanobodies immunotarget two different epitopes simultaneously on and firmly established naturally occurring human multiple...
Abstract Background Vasogenic cerebral edema resulting from blood–brain barrier (BBB) damage aggravates the devastating consequences of intracerebral hemorrhage (ICH). Although augmentation endothelial Wnt/β‐catenin signaling substantially alleviates BBB breakdown in animals, no agents based on this mechanism are clinically available. Lithium is a medication used to treat bipolar mood disorders and can upregulate signaling. Methods We evaluated protective effect lithium mouse model...
The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties brain endothelial cells (ECs), but the molecular foundation for these remains incompletely clear. Here, we generate comprehensive atlas adult ECs using acutely purified mouse and integrated multi-omics. Using RNA sequencing (RNA-seq) proteomics, identify transcripts proteins selectively enriched in demonstrate that they are partially correlated. single-cell RNA-seq, dissect basis functional...
Alzheimer's disease (AD) involves a prolonged presymptomatic or preclinical stage with subtle pathological changes. Apolipoprotein E4 (APOE4) is significant genetic risk factor for AD, yet its specific role at the not fully understood. This study aimed to elucidate cellular and molecular effects of APOE4 compared APOE3 on AD progression during stage. We generated 5xFAD mice carrying human their non-AD controls. Behavioral tests, immunostaining, quantitative proteomics phosphoproteomics,...
In recent years, the population of Brachymystax lenok tsinlingensis has experienced a rapid decline due to habitat degradation caused by overfishing and dam construction. current study, water samples were collected from four tanks containing B. individuals with wet weights 5.8 g, 12.3 34.7 81.7 respectively, cycle threshold (Ct) values in each tank measured using quantitative PCR. Additionally, six sites along Zhouzhi Heihe River (Yu Dongquan, Ban Fangzi, Ba Mugou, two Wang Jia, Qingshui...
Abstract Developing and transitional countries devote considerable funds to selected areas stimulate local growth firm productivity. We examine the impact of place‐based interventions due opening science parks in Shenzhen, China, on productivity factor use. Our identification strategy, exploiting spatial temporal differencing firm‐level data, addresses issues that (a) selection park locations is not random (b) high‐productivity firms sort themselves into parks. Firm approximately 15–25%...
Treatment of acute ischemic stroke with the recombinant tissue plasminogen activator (rtPA) is associated increased blood-brain barrier (BBB) disruption and hemorrhagic transformation. Remote conditioning (RIC) has demonstrated neuroprotective effects against stroke. However, whether how RIC regulates rtPA-associated BBB remains unclear. Here, a rodent model thromboembolic followed by rtPA thrombolysis at different time points was performed or without RIC. Brain infarction, neurological...
A quality evaluation of precise products for BDS-3 constellations is presented the first time in this contribution. Then, tropospheric delay retrieval and positioning performance point (PPP) solutions using (gbm, wum, iac, sha, cnt) with observations from 24 stations DOY 280 to 317 2020 was comprehensively investigated. The orbit comparisons present consistencies 0.09–0.22 m C19–C37 satellites 0.5–1.2 C38–C46 among final products. standard deviation (STD) values clock differences iac showed...
Precise point positioning-real-time kinematic (PPP-RTK) positioning combines the advantages of PPP and RTK, which enables integer ambiguity resolution (IAR) without requiring a reference station nearby. The ionospheric corrections are delivered to users enable fast IAR. For large-scale networks, precise interpolation delays is challenging. often independently estimated by user, in so-called ionosphere-float mode. augmentation low Earth orbit (LEO) satellites can bridge this shortcoming...
About 65 years ago, Francis Crick proposed the "central dogma" of molecular biology, outlining to flow genetic information from DNA RNA, and ultimately protein synthesis.Over years, discoveries RNA editing, alternative splicing, epigenetic modification, retroviruses greatly enriched content central dogma.This fundamental process still frame how we understand life.Aging is a highly complex biological affected by multiple pathways, some which are intricately linked replication, transcription,...