A5050531536- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Dermatological and COVID-19 studies
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Hereditary Neurological Disorders
- CAR-T cell therapy research
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Liver Diseases and Immunity
- Calpain Protease Function and Regulation
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Chromatin Remodeling and Cancer
- Pancreatic and Hepatic Oncology Research
Hainan Medical University
2019-2025
Hainan Medical College Hospital
2018
Liver cancer is closely linked to chronic inflammation. While observational studies have reported positive associations between extrahepatic immune-mediated diseases and systemic inflammatory biomarkers liver cancer, the genetic association these traits remains elusive merits further investigation. We conducted a two-sample Mendelian randomization (MR) analysis, using as exposures outcome. The summary data of both outcome were retrieved from previous genome-wide (GWAS). Four MR methods,...
ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most progression CHOL and chemotherapy efficacy. PHF10, one subunit SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis. However, roles PHF10 remains unclear. Here, we utilised bioinformatic analysis reveal lowly samples relative normal tissues. Functionally, demonstrated deficiency enhanced cell...
Introduction: Hepatocellular carcinoma (HCC) patients may benefit from chemotherapy, but drug resistance is an important obstacle to favorable prognoses. Overcoming urgent problem be solved. Methods: Differential expression analysis was used identify long non-coding RNAs (LncRNAs) that differed in chemotherapy-sensitive and chemotherapy-resistant patients. Machine learning algorithms including random forest (RF), lasso regression (LR), support vector machines (SVMs) were chemotherapy-related...
Sorafenib has been approved as a systemic drug for advanced liver cancer; however, the underlying mechanisms remain unclear. The present study aimed to investigate effects of sorafenib on proliferation, autophagy and apoptosis HepG2 cells under hypoxia. Briefly, reverse transcription-quantitative PCR western blotting was performed quantify HIF-1, LC3II/I, mTOR p70s6K expression levels. Cell proliferation determined using Counting Kit‑8 assay cell rate evaluated flow cytometry. results...
Stomach adenocarcinoma (STAD) has a high mortality rate due to the lack of highly sensitive biomarkers. Therefore, search for potential tumor markers is great value. ASF1B prognostic marker variety tumors, while value and immune microenvironment in STAD remain unclear, be determined. Kaplan-Meier analysis was performed analyze role STAD. Functional enrichment explored with GO KEGG pathway analysis. We also correlation between expression infiltration significantly upregulated tissues...
Objective To study the curative efficacy of non-specific immunotherapy in patients with hepatocellular carcinoma after radiofrequency ablation. Methods The clinical data 120 our hospital from December 2012 to 2014 were retrospectively analyzed. According different methods treatment operation, they divided into observation group (n=60) and control (n=60). All underwent elective operation ablation, was treated routine while (recombinant human interleukin-2 injection+ thymalfasin+...