A5036081654- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Neurological Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- Pancreatic and Hepatic Oncology Research
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Gut microbiota and health
- Alkaloids: synthesis and pharmacology
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Traditional and Medicinal Uses of Annonaceae
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hainan Medical University
2022-2025
Hainan Medical College Hospital
2024
ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most progression CHOL and chemotherapy efficacy. PHF10, one subunit SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis. However, roles PHF10 remains unclear. Here, we utilised bioinformatic analysis reveal lowly samples relative normal tissues. Functionally, demonstrated deficiency enhanced cell...
Liver hepatocellular carcinoma (LIHC) encompasses diverse therapeutic approaches, among which targeted therapy has gained significant prominence in recent years. The identification of numerous targets and the increasing clinical application drugs have greatly improved LIHC treatment. However, precise role CDCA4 (Cell Division Cycle Associated 4), as well its underlying mechanisms prognostic implications LIHC, remains unclear. expression levels were analyzed using multiple databases including...
Circular RNAs (circRNAs) have been shown to play important regulatory roles in many human diseases, yet their functions pulpitis remain be clarified. This study was designed investigate the function of circ_0138960 progression and its underlying mechanism.Cell viability proliferation were analyzed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay 5-Ethynyl-2'-deoxyuridine (EdU) assay. Flow cytometry enzyme-linked immunosorbent (ELISA) conducted analyze cell...
A rapid, sensitive, selective, and accurate HPLC–MS/MS method was developed validated for the simultaneous determination of chlorogenic acid, naucleactonin C, khaephuoside 3,4-dimethoxyphenyl-1-O-β-apiofuroseyl(1 ⟶ 2)-β-D-glucopyranoside in rat plasma tissues after oral administration Nauclea officinalis extracts. Chloramphenicol used as an internal standard (IS). The tissue samples were extracted by protein precipitation with methanol-ethyl acetate (1 : 1, v/v) including 0.1% (v/v) formic...