A5101964941- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Gut microbiota and health
- Angiogenesis and VEGF in Cancer
- Dysphagia Assessment and Management
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Parasitic Infections and Diagnostics
- Mitochondrial Function and Pathology
- FOXO transcription factor regulation
- Parasite Biology and Host Interactions
- Eicosanoids and Hypertension Pharmacology
- Renal and related cancers
- Microbial metabolism and enzyme function
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Botulinum Toxin and Related Neurological Disorders
- Extracellular vesicles in disease
- Helminth infection and control
- Glioma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
Yangzhou University
2025
Shanxi University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023-2024
Wenzhou Medical University
2023-2024
Tongji Hospital
2019-2022
University of Michigan
2022
Wuhan University of Science and Technology
2022
Huazhong University of Science and Technology
2022
Affiliated Hospital of Nantong University
2020
Nantong University
2020
Abstract Periodontitis is a common type of inflammatory bone loss and risk factor for systemic diseases. The pathogenesis periodontitis involves dysregulation, which represents target new therapeutic strategies to treat periodontitis. After establishing the correlation cell-free DNA (cfDNA) level with in patient samples, we test hypothesis that cfDNA-scavenging approach will benefit treatment. We create nanoparticulate cfDNA scavenger specific by coating selenium-doped hydroxyapatite...
Significance The tamoxifen (TAM)-inducible CreER/LoxP system is one of the most widely used genetic tools that have enabled precise gene manipulation in distinct cell subpopulations at any specific time point and labeling types for fate mapping. We report administration TAM during early stages cortical neurogenesis inhibits neural progenitor proliferation impaired neurogenesis, dendritic morphogenesis, synaptic density, gliogenesis postnatal offspring. By employing single-cell RNA sequencing...
This study investigated the infection rates of intestinal parasites in captive wild animals from 2000 to 2024 and analyzed associated risk factors using a meta-analysis. We retrieved 29 studies, with total 8421 mammals, published between 2024. used DerSimonian-Laird model calculated rate estimates variance stabilizing double arcsine transformation. The results revealed that overall prevalence gastrointestinal parasitic infections mammals mainland China was found be 53.9%. highest observed...
Colorectal cancer (CRC) is a common and aggressive malignancy with the complex varied molecular landscape. Mitochondria play pivotal role in metabolic reprogramming of cells, their function can profoundly influence tumor progression. Therefore, identifying mitochondrial genes immune-related features may offer promising new approach for prognosis CRC. Mitochondrial-associated were retrieved from MITOCARTA 3.0 dataset. The LASSO regression method was applied to identify prognostic genes, while...
Beak and feather disease virus is a member of the family Circoviridae, among birds, parrots are susceptible hosts. This study reported global molecular prevalence risk factors BFDV infection in parrot species. Relevant studies were identified from PubMed, Scopus, Web Science, China National Knowledge Infrastructure (CNKI), WanFang databases. We retrieved 30 encompassing 16,901 species across six continents 34 countries, all published between 2003 2024. The results showed that BFDV, based on...
Myocardial mitochondrial dysfunction is the leading cause of chronic heart failure (CHF). Increased reactive oxygen species (ROS) levels, disruption biogenesis and Ca2+([Ca2+]m) homeostasis reduction membrane potential (ΔΨm) myocardial dysfunction. Therefore, treating CHF by targeting function a focus current research. For first time, this study investigated effects strong antioxidant pyrroloquinoline quinone (PQQ) on in cardiac pressure overload model, mechanism which PQQ regulates [Ca2+]m...
Previous studies have implied the potential impact of gut microbiota on acute ischemic stroke (AIS), but relationships with basal ganglia region infarction (BGRI) and predictive power in BGRI prognosis is unclear. The aim this study was to ascertain characteristic taxa patients different functional outcomes identify their value. Fecal samples 65 were collected at admission analyzed 16s rRNA gene sequencing. Three-month evaluated using modified Rankin Scale (mRS), mRS score 0–1 assigned...
Background: Angiogenesis is critical for the growth and metastasis of solid tumors is, therefore, an important therapeutic target. Despite great research advances in tumor therapies targeting vascular endothelial factor (VEGF), drug resistance frequently occurs, further strategies vasculature are primary concern. Purpose: The present study aimed to determine whether a combination small interfering RNAs (siRNAs) VEGF-A angiopoietin-2 (Ang-2) inhibited biologic mechanisms endometrial cancer...
Numerous studies have reported alterations in the composition of gut microbiota patients with acute ischemic stroke (AIS), changes becoming more pronounced as disease progresses. However, association between progression transient attack (TIA) and AIS remains unclear. This study aims to elucidate microbial differences among TIA, AIS, healthy controls (HC) while exploring associations microbiota.
Summary CreER/LoxP system has enabled precise gene manipulation in distinct cell subpopulations at any specific time point upon tamoxifen (TAM) administration. This is widely accepted to track neural lineages and study functions. We have observed prenatal TAM treatment caused high rate of delayed delivery mortality pups. These substances could promote undesired results, leading data misinterpretation. Here, we report that administration during early stages cortical neurogenesis promoted...