A5101438802- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- Syphilis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Genital Health and Disease
- Vaccine Coverage and Hesitancy
- Cytomegalovirus and herpesvirus research
- Contact Dermatitis and Allergies
- Hepatitis B Virus Studies
- Primary Care and Health Outcomes
- Cannabis and Cannabinoid Research
- Mast cells and histamine
- HIV-related health complications and treatments
- Natural Compounds in Disease Treatment
- Immune responses and vaccinations
- Atrial Fibrillation Management and Outcomes
- Child Nutrition and Water Access
- Management of metastatic bone disease
- HIV/AIDS oral health manifestations
- Extracellular vesicles in disease
Second Military Medical University
2023
Shanghai Pudong New Area Gongli Hospital
2023
Westat (United States)
2007-2020
Supernus Pharmaceuticals (United States)
2020
Chongqing Academy of Chinese Materia Medica
2011-2018
National Institute of Mental Health
2016
National Institutes of Health
2016
Indiana University – Purdue University Indianapolis
2016
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016
Johns Hopkins University
2005-2016
The safety and efficacy of adding antiretroviral drugs to standard zidovudine prophylaxis in infants mothers with human immunodeficiency virus (HIV) infection who did not receive antenatal therapy (ART) because late identification are unclear. We evaluated three ART regimens such infants.
High rates of persistence human papillomavirus (HPV) infection have been reported for adult women with immunodeficiency virus (HIV) infection. Although most are first infected HPV during adolescence, specific types has not carefully examined among HIV-infected adolescents. The objective this study was to examine the and risk factors -uninfected adolescent girls.This is a prospective cohort female adolescents, aged 13-18 years, participating in Reaching Excellence Adolescent Care Health...
The objective of this study was to determine whether the 3-dose quadrivalent human papillomavirus (HPV) vaccine series (HPV-6, -11, -16, -18) is immunogenic and safe in young women infected with immunodeficiency virus (HIV). We enrolled 99 aged 16–23 years a phase 2, open-label, multicenter trial, conducted from 2008 2011 by Adolescent Medicine Trials Network for HIV/AIDS Interventions. Outcome measures were immunogenicity 4 weeks after dose 3, measured (1) geometric mean titers (GMTs) (2)...
Background: Almost one-quarter of all new HIV diagnoses in the United States occur among persons aged 13–24 years. These youths have poorest care continuum (HCC) outcomes, yet few empirical youth-specific data are available. Methods: The Strategic Multisite Initiative for Identification, Linkage, and Engagement Care HIV-infected youth (SMILE) helped (mostly newly diagnosed) youth, 12–24 years, link to youth-friendly care, evaluated each milestone HCC (October 2012–September 2014). Numbers...
In China, many former plasma donors were infected with the human immunodeficiency virus (HIV) in early-mid-1990s. Highly active antiretroviral therapy (HAART) was provided for beginning 2002. The effect of HAART on mortality this cohort has not been described.This study is a retrospective analysis national HIV epidemiology and treatment databases period 1993-2006. All HIV-infected subjects from 10 counties high prevalence infection 6 provinces eligible. Inclusion criteria were: (1) history...
In Brief Background Sexually transmitted infections (STIs) such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) can lead to adverse pregnancy neonatal outcomes. The prevalence of STIs its association with HIV mother-to-child transmission (MTCT) were evaluated in a substudy analysis from randomized, multicenter clinical trial. Methodology Urine samples HIV-infected pregnant women collected at the time labor delivery tested using polymerase chain reaction testing for detection CT...
We tested the association between availability of primary care and income inequality on several categories mortality in US counties.We used cross-sectional analysis data from counties (n=3081) 1990, including variance multivariate ordinary least squares regression. Independent variables included resources, inequality, sociodemographics.Counties with higher resources experienced 2% 3% lower than less care. Counties high 11% 13% inequality.Primary may partially moderate effects health outcomes...
ABSTRACT The clinical application of conventional peptide drugs often is limited by their short in vivo half-life and potential immunogenicity. Frequent injection presents challenges to the treatment chronic diseases, such as HIV infection. We chemically modified a fusion inhibitor with 3-maleimidopropionic acid (MPA), which allows rapid irreversible conjugation serum albumin at 1:1 molar ratio. FB006M, an MPA modification 13th amino acid, rapidly formed conjugate upon intravenous injection,...
Pre-exposure prophylaxis (PrEP) is indicated for use in US adults, and little known about clinician intentions to prescribe actual prescription of PrEP adolescents younger than 18. Fifty-six clinicians who care HIV-infected at-risk youth completed an anonymous online survey 2014. Primary outcomes were (1) adults four risk categories [men have sex with men (MSM), transgender women, heterosexuals multiple partners unknown HIV status, partners]; (2) these groups. Independent variables included...
Sexually transmitted infections (STIs) in pregnancy such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) may lead to adverse infant outcomes.Individual urine specimens from HIV-infected pregnant women diagnosed with HIV during labor were collected at the time of birth tested by polymerase chain reaction for CT NG. Infant infection was determined 3 months morbidity/mortality assessed through 6 months.Of 1373 maternal samples, 277 (20.2%) positive and/or NG; 249 (18.1%) CT, 63...
Background Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated mother-infant pairs from NICHD HPTN 040. Methodology Urine samples HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, CMV. Infant infection...
The risk of developing the human papillomavirus (HPV)-associated precancer high-grade squamous intraepithelial lesion (HSIL) in immunodeficiency virus (HIV)-infected adolescents is unknown. We examined HSIL among with and without HIV infection.HIV-infected (n = 172) -uninfected 84) girls aged 13-18 years who were participating a multicenter study primarily horizontally acquired infections (Reaching for Excellence Adolescent Health Care) did not have on cytologic examination at entry or first...
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia in humans and responsible for substantial morbidity mortality worldwide.Emerging evidence indicates that abnormal cardiovascular development involved pathogenesis AF.In this study, coding exons splice sites NKX2-5 gene, which encodes a homeodomain-containing transcription factor essential genesis, were sequenced 146 unrelated patients with lone AF as well available relatives mutation carriers.A total 700...
Background Since it was initiated in 2002, the China Free Antiretroviral Treatment (ART) Program has been progressing from an emergency response to a standardized treatment and care system. As of December 31, 2009, total 81,880 patients 31 provinces, autonomous regions, special municipalities received free ART. Gender differences, however, mortality immunological ART this cohort have never described. Objective To understand whether women men who enrolled National responded equally well...
Background: The Trauma Infectious Disease Outcomes Study (TIDOS) cohort follows military personnel with deployment-related injuries in order to evaluate short- and long-term infectious complications. High rates of complications have been observed more than 30% injured patients during initial hospitalization. We present data on related combat trauma after the period Patients Methods: Data patient care for operations between June 2009 May 2012 were collected. Follow-up captured from interviews...
Objective: Certain cervicovaginal lavage (CVL) fluid samples obtained from HIV-1-infected and uninfected women stimulate in vitro HIV-1 replication. This activity, HIV-inducing factor (HIF), changes when CVL is heated. We sought to confirm a previous observation that HIF was associated with bacterial vaginosis (BV). Methods: measured unheated heated compared the presence of BV by Nugent scores, other genital tract conditions, shedding. Results: Among 295 studied, 54% had activity 21% showed...
Cytomegalovirus (CMV) urinary shedding in pregnant women infected with human immunodeficiency virus (HIV) was evaluated to determine whether it poses an increased risk for congenital CMV infection (cCMV).A subset of mother-infant pairs enrolled the perinatal NICHD HPTN 040 study (distinguished by no antiretroviral use before labor) evaluated. Maternal and infant urines were tested qualitative real-time polymerase chain reaction (RT-PCR) DNA quantitative RT-PCR performed on positive...
Background: HIV-exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed enrolled the NICHD HPTN 040/PACTG 1043 trial. Methods: Infectious morbidity, undernutrition were within cohort of 1000 between April 2004 2010 Brazil (n = 766) South Africa 234) as part NICHD/HPTN 040 trial 3 different antiretroviral regimens to decrease intrapartum HIV vertical transmission. Results: Twenty-three percent had...
To examine how the time from HIV testing to care referral and linkage influenced engagement for newly diagnosed HIV-infected adolescents.We evaluated Care Initiative, a program adolescents in 15 US clinics. We analyzed client-level factors, provider type, intervals as predictors of engagement. Engagement was defined second HIV-related medical visit within 16 weeks initial (linkage).At 32 months, 2143 youth had been referred. Of these, 866 were linked through Initiative 42 days thus eligible...
The relationship betweenhumanimmunodeficiencyvirus(HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA CMV DNA found the CVL specimens, which also were tested for cytokine levels. Women with detectable more likely to have higher interleukin (IL)-1β IL-8 levels than women undetectable specimens. More strain of detected 2 patients. These results suggest mechanisms by...
A simplified version of the HIVNET prototype HIV vaccine process was developed for adolescents at risk by:(1) reducing reading level; (2) reorganizing; (3) adding illustrations; and (4) obtaining focus group feedback. Then (N = 187) in three cities were randomly assigned to standard or version. Adolescents receiving had significantly higher comprehension scores (80% correct vs. 72% correct), with 37% items more likely be answered correctly. They also recall study benefits procedures....