A5061780217- Enzyme Catalysis and Immobilization
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Enzyme Production and Characterization
- Pharmacological Effects of Natural Compounds
- Amino Acid Enzymes and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Protein Hydrolysis and Bioactive Peptides
- Genomics, phytochemicals, and oxidative stress
- Microbial Metabolites in Food Biotechnology
- Meat and Animal Product Quality
- Glycosylation and Glycoproteins Research
- Medicinal plant effects and applications
- Biochemical effects in animals
- Monoclonal and Polyclonal Antibodies Research
- Listeria monocytogenes in Food Safety
- Microbial Inactivation Methods
- Tryptophan and brain disorders
- Carbohydrate Chemistry and Synthesis
- Hepatitis C virus research
- Protein Structure and Dynamics
- Biochemical Acid Research Studies
- Fungal Biology and Applications
State Key Laboratory of Food Science and Technology
2024-2025
Jiangnan University
2024-2025
Food Research Institute
2025
Shaoguan University
2024
Vertex Pharmaceuticals (United States)
1997
Hepatitis C virus encodes a large polyprotein precursor that is proteolytically processed into at least 10 distinct products, in the order NH2-C-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B -COOH. A serine proteinase encoded N-terminal 181 residues of NS3 nonstructural protein responsible for cleavage four sites (3/4A, 4A/4B, 4B/5A, and 5A/5B) region. NS4A, 54-residue which forms stable complex with proteinase, required as cofactor 3/4A 4B/5A enhances processing 4A/4B 5A/5B sites. Recently reported...
Loop dynamics redesign is an important strategy to manipulate protein function. Cellobiose 2-epimerase (CE) and other members of its superfamily are widely used for diverse industrial applications. The structural feature the loops connecting barrel helices contributes greatly differences in their functional characteristics. Inspired by in-silico mutation with molecular (MD) simulation analysis, we propose a identifying disulfide bond candidates based on prediction flexibility residue–residue...
Insulin resistance (IR) is a complex metabolic disorder characterized by diminished insulin sensitivity, leading to impaired glucose uptake and potential progression hyperglycemia diabetes. While lifestyle modifications are essential, the limitations of current pharmacological interventions highlight need for natural products with therapeutic benefits. This study introduces two novel dihydroquercetin (DHQ) derivatives, 8-hydroxy-dihydroquercetin (H-DHQ)...