A5089959321- Renal and related cancers
- Air Quality and Health Impacts
- Pesticide Exposure and Toxicity
- Congenital Diaphragmatic Hernia Studies
- Air Quality Monitoring and Forecasting
- Biomarkers in Disease Mechanisms
- Neonatal Respiratory Health Research
Cincinnati Children's Hospital Medical Center
2024
University of Cincinnati
2024
Rutgers, The State University of New Jersey
2022-2023
Summary To investigate the co-development of vasculature, mesenchyme, and epithelium crucial for organogenesis acquisition organ-specific characteristics, we constructed a human pluripotent stem cell-derived organoid system comprising lung or intestinal surrounded by organotypic mesenchyme vasculature. We demonstrated pivotal role co-differentiating mesoderm endoderm via precise BMP regulation in generating multilineage organoids gut tube patterning. Single-cell RNA-seq analysis revealed...