Liat Fellus-Alyagor
A5005733032- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Protein Degradation and Inhibitors
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Birth, Development, and Health
- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Macrophage Migration Inhibitory Factor
- Pancreatitis Pathology and Treatment
- Pregnancy and preeclampsia studies
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Advanced Fluorescence Microscopy Techniques
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- interferon and immune responses
Weizmann Institute of Science
2015-2025
Hebrew University of Jerusalem
2024
Abstract The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory cycle. Maturation of ovarian follicle, release oocyte in course ovulation as well formation and degradation corpus luteum involve tightly controlled extracellular matrix vasculature. Ovarian tumors, regardless their tissue origin, dynamically interact with microenvironment. Their activity encompasses recruitment host stroma immune cells, attachment tumor cells to mesothelial layer, cell...
Abstract Multiple studies have identified metabolic changes within the tumor and its microenvironment during carcinogenesis. Yet, mechanisms by which tumors affect host metabolism are unclear. We find that systemic inflammation induced cancer leads to liver infiltration of myeloid cells at early extrahepatic The infiltrating immune via IL6–pSTAT3 immune–hepatocyte cross-talk cause depletion a master regulator, HNF4α, consequently leading promote breast pancreatic proliferation worse outcome....
Reconstructing gene expression atlases for human tissues is challenging due to limited access healthy samples from live donors. Neurologically deceased donors often show ischemic changes, while near diseased regions may have altered expression. The liver, with its unique regenerative capacity, allows analysis (LHDs). Using spatial transcriptomics (Visum, Visium HD and MERFISH), we analyzed 16 liver samples: eight young LHDs patients pathology, sampling adjacent normal tissue. LHD livers...
<p>Differential expression analysis of rejected vs. non-rejected tumor cells.</p>
<p>Supplementary data linked to the in vivo CRISPR screen.</p>
<p>Cell types from scRNA-seq of tumors mice inoculated with rejected or non-rejected SCCs.</p>
<p>Evaluation of Mif expression in stromal cells, and its effect on patient survival.</p>
<p>Analysis of tissue microarray biopsies from cancer patients.</p>
<p>CyTOF analysis comparing tumors derived from Mif WT and KO validating the scRNAseq findings.</p>
<p>Highest Mif expression was found in tumor cells, compared to other cell types.</p>
<p>Immunopeptidomics and TCR sequencing analyses showed similar results for the rejected non-rejected SCCs.</p>