A5043453579- Diet and metabolism studies
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acupuncture Treatment Research Studies
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Gastrointestinal motility and disorders
- Acute Lymphoblastic Leukemia research
- Pain Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Platelet Disorders and Treatments
- Complementary and Alternative Medicine Studies
- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
Inserm
2022-2025
Université de Tours
2022-2025
Queen's University
2020-2023
University of Balamand
2017-2018
West Virginia University Hospitals
2011
West Virginia University
2009-2011
Medical College of Wisconsin
2009
Objective Dietary therapies for irritable bowel syndrome (IBS) have received increasing interest but predicting which patients will benefit remains a challenge due to lack of mechanistic insight. We recently found evidence role the microbiota in dietary modulation pain signalling humanised mouse model IBS. This randomised cross-over study aimed test hypothesis that relief following reduced consumption fermentable carbohydrates is result changes luminal neuroactive metabolites. Design IBS...
Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons. The pathophysiology of ALS not well understood but TDP-43 proteinopathy (aggregation and mislocalization) one major phenomena described. Several factors can influence behavior such as mild pH alterations that induce conformational changes in recombinant TDP-43, increasing its propensity to aggregate. However our knowledge, no studies have been conducted yet a cellular setting, context...
Abstract Background In recent years, there has been growing awareness of metabolic dysfunction-associated steatotic liver disease (MASLD) linked to hypothyroidism. However, insufficient data exists on how levothyroxine (LT4) replacement therapy impacts MASLD. We aimed assess the effects LT4 treatment dyslipidemia and MASLD in patients with subclinical hypothyroidism (SCH). Methods a randomized, controlled study, 230 were screened for SCH, 182 diagnosed SCH. Of these, 30 had significant SCH...
TDP-43 proteinopathies are a set of neurological disorders characterized by the abnormal accumulation and mislocalization in cytoplasm, leading to disruption normal function protein. In most cases, it is wildtype (wt) form protein that involved. An untargeted high-throughput screen single-chain variable fragment (scFv) library was performed using phage display against human full-length wt TDP-43. Two scFvs (B1 D7) were retained following cellular expression (then termed intrabodies)...
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Objective Over the past years, interest in role of gut microbiota neurodegenerative diseases has emerged. Despite numerous publications over decade, both human and pre-clinical studies, there is no clear consensus on microbiota's or involvement ALS. Few studies mouse models ALS highlighted a correlation between specific bacteria species prognostic severity disease. Still these results lack reproducibility remain controverted. In this article we present study fecal SOD1G93A model associated...
Introduction. This study evaluates the secondary cancer risks associated with low-dose ionizing radiation from pelvic cone beam computed tomography (CBCT) imaging protocols in context of image-guided radiotherapy (IGRT). Methods. The research identifies that effective dose varies significantly protocol choice and field size; larger fields result higher doses, emphasizing need for optimization to balance diagnostic accuracy safety. Results. Protocols such as Pelvis Fast, characterized by...
Background: Interleukin (IL)-37, a novel anti-inflammatory cytokine previously known as interleukin-1 family member 7 before it was renamed, has pivotal role in the suppression of immune responses.Objective: The present study aimed to investigate expression IL-37 and its potential pathogenesis thrombocytopenia (ITP).Patients Methods: carried out Zagazig University Hospital, Pediatric Department.The total sample size 60 participants divided into 4 groups.They were 45 patients (15 with newly...
Abstract Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons. The pathophysiology of ALS not well understood but TDP-43 proteinopathy (aggregation and mislocalization) one major phenomena described. Several factors can influence behavior such as mild pH alterations that induce conformational changes in recombinant TDP-43, increasing its propensity to aggregate. However our knowledge, no studies have been conducted yet a cellular setting,...
In vivo TCD is commonly employed to prevent graft rejection and GVHD in patients undergoing AHCT. Published (but controversial) data suggest possible benefit with the setting of unrelated donor (URD), HLA-mismatched We report here outcomes for who received transplant conditioning (TCD group) compare them T-cell replete allografts (non-TCD group). The study cohort consists 150 consecutive underwent AHCT between 2003 2009. All peripheral blood allografts. consisted alemtuzumab (20mg on days -4...
e11611 Background: Fluorine-18-FDG positron emission tomography (FDG-PET) role in the follow up care of non-metastatic breast cancer is not defined. Methods: We retrospectively analyzed 177 patients with stage I-III between November 2004 and June 2006. IRB approval was obtained for this study. Patients were divided into two groups. Group A consisted who had one or more FDG-PET scans as part their clinical (N=68), B did (N=109). Clinical, radiological pathology data from patients’ records....
Abstract Background Visceral pain is a primary symptom of many gastrointestinal diseases. One feature visceral its vague localization. We hypothesized that overlap in the receptive fields spinal afferent neurons innervate gut may contribute to this Many studies have confirmed proximal and distal colon are mainly innervated by with cell bodies thoraco-lumbar lumbo-sacral dorsal root ganglia (DRG), respectively. However, no murine examined whether individual DRG simultaneously both colon. Aims...
Activation of the RET receptor tyrosine kinase stimulates signaling pathways associated with cell proliferation, growth, differentiation, and survival. Changes in expression this its ligands have been linked to tumorigenesis several tumor types, including pancreatic cancer. It has established that cells can migrate towards invade nervous system, a process called perineural invasion is metastasis reduced Given play important roles spinal afferent neuronal development morphology, we...
Abstract Background Abdominal pain is commonly described in chronic disorders such as irritable bowel syndrome (IBS), but the underlying mechanisms are currently unclear. The stool metabolomic and microbiota profiles of IBS healthy patients have shown distinct differences. Additionally, supernatants previously been demonstrated to induce hypersensitivity nociceptive nerves ex vivo mouse colon, suggesting that mediators can sensitize nociceptors. However, effects control (HC) or patient on...