A5102738082- Metabolomics and Mass Spectrometry Studies
- Amyotrophic Lateral Sclerosis Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Metabolism and Genetic Disorders
- Spectroscopy and Chemometric Analyses
- Neurogenetic and Muscular Disorders Research
- Mass Spectrometry Techniques and Applications
- Folate and B Vitamins Research
- Neonatal Health and Biochemistry
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Acid Research Studies
- Neuroendocrine Tumor Research Advances
- Genetics and Neurodevelopmental Disorders
- Biosimilars and Bioanalytical Methods
- Parkinson's Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Respiratory viral infections research
- RNA Research and Splicing
- Advanced Chemical Sensor Technologies
- Safe Handling of Antineoplastic Drugs
- Poisoning and overdose treatments
- Bee Products Chemical Analysis
- Prion Diseases and Protein Misfolding
- Analytical Chemistry and Chromatography
- Blood transfusion and management
Centre Hospitalier Universitaire de Tours
2016-2025
Thion Medical (France)
2024
Université de Tours
2015-2022
Inserm
2016-2022
Laboratoire de Microbiologie et Génétique Moléculaires
2019
Nanomed (Brazil)
2019
Hôpital Bretonneau
2016
Imagerie et Cerveau
2016
Centre National de la Recherche Scientifique
2015
This study explores the suitability of Raman spectroscopy as a bioanalytical tool, when coupled with ultra-filtration and multivariate analysis, to detect imbalances in both high molecular weight (total protein content, γ globulins albumin) low (urea glucose) fractions same samples human patient serum, native liquid form. Ultracentrifugation was employed separate concentrate serum. Initially, aqueous solutions respective species, covering physiologically relevant concentration ranges, were...
Analysis of biomarkers present in the blood stream can potentially deliver crucial information on patient health and indicate presence numerous pathologies. The potential vibrational spectroscopic analysis human serum for diagnostic purposes has been widely investigated and, recent times, infrared absorption spectroscopy, coupled with ultra-filtration multivariate techniques, attracted increasing attention, both clinical commercial. However, such methods commonly employ a drying step, which...
Objectives Autism spectrum disorders and intellectual disability present a challenge for therapeutic dietary management. We performed re-analysis of plasma amino acid chromatography children with autism ( n = 22) or 29) to search metabolic signature that can distinguish individuals these from controls 30). Methods univariate multivariate analyses using different machine learning strategies, the raw data chromatography. Finally, we analysed pathways associated discriminant biomarkers. Results...
Diverse biomarkers and pathological alterations have been found in muscle of patients with Amyotrophic lateral sclerosis (ALS), but the relation between such dysfunction energetic metabolism remains to be investigated. We established metabolome serum ALS correlated these findings clinical status observed muscle. obtained data from 20 controls 17 (disease duration: 9.4 ± 6.8 months). Multivariate metabolomics analysis identified a distinct for compared (p-CV-ANOVA < 0.035) revealed an...
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. The immunosuppressive functions of regulatory T lymphocytes (Tregs) are impaired in ALS, and correlate to disease progression. phase 2a IMODALS trial reported an increase Treg number ALS patients following the administration low-dose (ld) interleukin-2 (IL-2). We propose pharmacometabolomics approach decipher metabolic modifications occurring treated with ld-IL-2 its relationship response. Blood metabolomic profiles...
Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs available for ALS treatment, and their modest effect prompts researchers to search new therapeutic options. represents one the most promising targets intervention, but reliable reproducible in vitro protocols TDP-43-mediated toxicity lacking. Here, we used HEK293T cells transfected with increasing concentrations TDP-43-expressing plasmid evaluate different parameters alterations...
Cytotoxics are usually prepared in a centralized pharmacy unit controlled hospital environment. Despite the rigorous operating procedures used for such preparations, contamination is theoretically possible – example due to vial switches. Therefore products ought be checked order determine whether quality control measures adequate. Numerous strategies have been applied locally ensure safety of both patients and operators but efficacy these methodologies has not previously examined. The aim...
Homocysteine (Hcy) is monitored in a growing number of diseases and requires rapid reliable method to measure its concentration routine practice. We validated new mass spectrometry plasma Hcy determinate our own targeted concentrations according COFRAC (French accreditation committee) recommendations. collected the measured laboratory from 2014 2015 we compared values between different clinical groups. obtained excellent performances reproducibility, sensitivity (coefficient variation <10%)....
plaquettaire et du 5-HIAA urinaire pour le diagnostic des tumeurs neuroendocrines digestives ?