A5103186650- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- PARP inhibition in cancer therapy
- Bacterial Genetics and Biotechnology
- Neuroendocrine regulation and behavior
- CRISPR and Genetic Engineering
- Stress Responses and Cortisol
- Plant Genetic and Mutation Studies
- Tryptophan and brain disorders
- Integrated Circuits and Semiconductor Failure Analysis
- Gender Diversity and Inequality
- Genomics and Chromatin Dynamics
- Work-Family Balance Challenges
- Job Satisfaction and Organizational Behavior
Northeastern University
2024
Emory University
2014
Temple University
2006-2008
Sidney Kimmel Cancer Center
2003-2005
Poly(ADP-ribose)polymerase 1 (PARP-1) recognizes DNA strand interruptions in vivo and triggers its own modification as well that of other proteins by the sequential addition ADP-ribose to form polymers. This causes a release PARP-1 from ends initiates variety responses including repair. While has been firmly implicated base excision single break repair, role repair double breaks (DSBs) remains unclear. Here, we show PARP-1, probably together with ligase III, operates an alternative pathway...
Abstract Biochemical and genetic studies support the view that majority of DNA double-strand breaks induced in genome higher eukaryotes by ionizing radiation are removed two pathways nonhomologous end joining (NHEJ) termed D-NHEJ B-NHEJ. Whereas depends on activities DNA-dependent protein kinase ligase IV/XRCC4, components B-NHEJ have not been identified. Using extract fractionation, we show activity extracts HeLa cells derives from III. III fractionates through columns with maximum its...
Cells of higher eukaryotes process within minutes double strand breaks (DSBs) in their genome using a non-homologous end joining (NHEJ) apparatus that engages DNA-PKcs, Ku, DNA ligase IV, XRCC4 and other as yet unidentified factors. Although chemical inhibition, or mutation, any these factors delays processing, cells ultimately remove the majority DSBs an alternative pathway operating with order magnitude slower kinetics. This is active mutants deficient genes RAD52 epistasis group...
In cells of higher eukaryotes double strand breaks (DSBs) induced in the DNA after exposure to ionizing radiation (IR) are rapidly rejoined by a pathway non-homologous end joining (NHEJ) that requires dependent protein kinase (DNA-PK) and is therefore termed here D-NHEJ. When this chemically or genetically inactivated, still remove majority DSBs using an alternative, backup operating independently RAD52 epistasis group genes with order magnitude slower kinetics (B-NHEJ). Here, we investigate...
The literature lacks clarity about the influence of family sacrifice behavior, which is considered a pro-family activity, on career aspirations partners. study employed interdependence theory and gender role to examine sample 248 double-working couples in China. hypotheses were tested using three-wave survey administered both parties. main aim investigate differences how employee behavior affects their partner’s aspirations. Furthermore, investigates moderating egalitarianism. Research...