A5043945804- COVID-19 Clinical Research Studies
- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Kawasaki Disease and Coronary Complications
- Respiratory viral infections research
- COVID-19 Impact on Reproduction
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- Infectious Diseases and Tuberculosis
- Dermatological diseases and infestations
- Diagnosis and treatment of tuberculosis
- Infant Nutrition and Health
- Pneumonia and Respiratory Infections
- Peripheral Neuropathies and Disorders
- Bartonella species infections research
- Virology and Viral Diseases
- Rabies epidemiology and control
- Pneumothorax, Barotrauma, Emphysema
- Streptococcal Infections and Treatments
Hospital for Sick Children
2023-2025
Office of Infectious Diseases
2024
University of Toronto
2021-2023
SickKids Foundation
2023
Western University
2018-2022
Western Caspian University
2018
Montreal Children's Hospital
2013-2014
McGill University
2013-2014
<h3>Background:</h3> SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought investigate risk factors for admission the intensive care unit (ICU) and explored changes disease severity over time. <h3>Methods:</h3> obtained data from chart reviews of younger than 18 years with confirmed or probable MIS-C who were admitted 15 hospitals Canada, Iran Costa Rica between Mar. 1, 2020, 7, 2021. Using multivariable analyses, we evaluated whether date other...
To identify risk factors for severe disease in children hospitalised SARS-CoV-2 infection.Multicentre retrospective cohort study.18 hospitals Canada, Iran and Costa Rica from 1 February 2020 to 31 May 2021.Children<18 years of age symptomatic PCR-positive infection, including multisystem inflammatory syndrome (MIS-C).Severity on the WHO COVID-19 Clinical Progression Scale was used ordinal logistic regression analyses.We identified 403 hospitalisations. Median 3.78 (IQR 0.53-10.77). At least...
Abstract Background Acute otitis media (AOM) and community-acquired pneumonia (CAP) are common reasons for antibiotic prescriptions in children. As a result, antimicrobial stewardship efforts ensuring evidence-informed may be impactful. The objective of this study was to assess whether AOM CAP pediatric emergency department (ED) consistent with current guidelines, identify opportunities improvement. Duration antibiotics prescribed acute Bar graph depicting durations therapy media,...
Abstract Background Recent evidence-based pediatric guidelines recommend a 5-day course of amoxicillin as first-line therapy for uncomplicated acute otitis media (AOM) in children 2 years and older community-acquired pneumonia (CAP). The objective this study was to assess the guideline consistency antibiotic prescriptions AOM CAP Canadian quaternary care emergency department (ED) identify opportunities improve prescribing. Methods We retrospectively reviewed patients 0 18 old discharged from...
Bartonella quintana is a rare but important cause of culture-negative endocarditis, classically associated with body lice infestation. We report the first known pediatric case endocarditis head lice. The importance sending targeted testing for this organism in at-risk patients, ideally on tissue specimens, emphasized.
Abstract BACKGROUND SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We investigated risk factors for severe disease and explored changes severity over time. METHODS Children up 17 years of age admitted March 1, 2020 through 7 th , 2021 15 hospitals Canada, Iran Costa Rica with confirmed or probable MIS-C were included. Descriptive analysis comparison by diagnostic criteria, country, admission date was performed. Adjusted absolute average risks (AR)...
Introduction: Vaccine-associated measles is generally not considered to be transmissible, as opposed wild-type measles, which one of the most highly contagious diseases. Data on contact and exposure management vaccine-associated limited, with varied approaches such cases described in literature. Methods: We report case a 2-year-old immunosuppressed child who developed febrile exanthem mild conjunctivitis 18 days after receiving measles-mumps-rubella-varicella vaccine. Results: Given...
Abstract Late-onset sepsis (LOS) in the neonatal intensive care unit (NICU) causes significant morbidity and mortality, yet guidance on empiric management is limited. We surveyed NICUs across Canada United States regarding their antimicrobial regimens for LOS, thereby identifying large practice variations high rates of vancomycin use.
Abstract Background The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or predictors unfavorable outcome. Methods In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network Infections Canada identified < 90 days age with infection proven be due enterovirus (EV) herpes simplex virus (HSV)...
A 15-year-old, previously healthy, Syrian-born girl, who had immigrated from Turkey 3 months previously, presented to the emergency department with a 6-month history of cervical swelling, weight loss and intermittent fevers; 1-month cough; acute onset night sweats. On
SARS-CoV-2 seroprevalence reflects the efficacy of pandemic infection prevention and control measures. We performed anti-spike IgG serological testing on residual sera children 1-11 years old at a tertiary care referral center between October November 2021. Immunocompromised patients had highest seroprevalence, 40.5%, compared to 19.3% in non-immunocompromised patients. Targeted public health interventions are warranted for pediatric immunocompromised future pandemics.
[Voir la version anglaise de l’article ici : www.cmaj.ca/lookup/doi/10.1503/cmaj.230700][1] Une jeune fille 15 ans d’origine syrienne et ayant immigré Turquie 3 mois plus tôt, jusqu’alors en santé, s’est présentée au service des urgences avec une enflure cervicale, perte
In the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy long-term prophylaxis improve outcomes, clinicians need to be able clinically detect young infants most likely have facilitate early initiation of therapy. Limited data exist on outcomes who require prolonged those completing prophylaxis. The objective this study identify clinical laboratory features disease describe following Infants <90 days old a...
Journal Article 44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity Get access Dara Petel, Petel Department Pediatrics, University Western Ontario, London, Canada Search for other works by this author on: Oxford Academic Google Scholar Michelle Barton, Barton Christian Renaud, Renaud Montreal, Quebec, Lynda Ouchenir, Ouchenir Jason Brophy, Brophy Ottawa, Jennifer Bowes, Bowes Children’s Hospital Eastern...
Abstract: Reye syndrome is seldom considered in the older child presenting with acute encephalopathy. The paucity of literature on past 30 years highlights importance sharing new observations this less-commonly disease. This case details an atypical presentation adolescent girl whose course was unexpectedly complicated by dialysis disequilibrium syndrome, occurring as a result rapid metabolic shifts setting urgent hemodialysis. A 14-year-old, previously healthy born to non-consanguineous...
Abstract Background The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or predictors unfavorable outcome. Methods In this cross-sectional study, the Pediatric Investigators Collaborative Network Infections Canada identified <90 days age with infection proven be due viruses. Results Of 174 causes accounted for 111 (64%) including enterovirus...
Abstract Background The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or predictors unfavorable outcome. Methods In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network Infections Canada identified <90 days age with infection proven be due enterovirus (EV) herpes simplex virus (HSV)...
Abstract Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or predictors unfavorable outcome. Methods: In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network Infections Canada identified <90 days age with infection proven be due enterovirus (EV) herpes simplex virus (HSV)...
Abstract Background The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or predictors unfavorable outcome. Methods In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network Infections Canada identified <90 days age with infection proven be due enterovirus (EV) herpes simplex virus (HSV)...