A5100821319- Tryptophan and brain disorders
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Genetic Associations and Epidemiology
- Gut microbiota and health
- CAR-T cell therapy research
- Diet and metabolism studies
- Fibroblast Growth Factor Research
- COVID-19 Clinical Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dendrimers and Hyperbranched Polymers
- Curcumin's Biomedical Applications
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Caveolin-1 and cellular processes
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Probiotics and Fermented Foods
Sun Yat-sen University
2011-2025
Chinese People's Liberation Army
2024-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Chengdu Military General Hospital
2023-2025
Northwest A&F University
2024-2025
Fudan University
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Respiratory Disease
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Abstract The heterogeneity of triple‐negative breast cancers (TNBC) remains challenging for various treatments. Ferroptosis, a recently identified form cell death resulting from the unrestrained peroxidation phospholipids, represents potential vulnerability in TNBC. In this study, high intensity focused ultrasound (HIFU)‐driven nanomotor is developed effective therapy TNBC through induction ferroptosis. Through bioinformatics analysis typical ferroptosis‐associated genes FUSCCTNBC dataset,...
Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a global pandemic. The Omicron variant (B.1.1.529) was first discovered in November 2021 specimens collected from Botswana, South Africa. become dominant worldwide, and several sublineages or subvariants have been identified recently. Compared to those of other mutants, most highly expressed amino acid mutations, with almost 60 mutations throughout genome, are...
Targeted synbiotic therapy mitigates cognitive impairment in Alzheimer's disease, emphasizing its potential for addressing neurodegenerative diseases.
Abstract We previously reported that RNF148 was involved in the ubiquitination-mediated degradation of CHAC2. However, its molecular mechanism not determined. In this study, we investigated role and progression colorectal cancer (CRC), especially process Our results revealed upregulated most CRC tissues, expression significantly correlated with 3-year overall survival rate clinicopathological parameters patients. Furthermore, served as an independent prognostic biomarker promoted cell...
The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind (FGF) ligands and block the activation FGF-signaling pathway. In this study, sFGFR2c inhibited lung fibrosis dramatically in vitro vivo. upregulation α-smooth muscle actin (α-SMA) fibroblasts by transforming factor-β1 (TGF-β1) an important step process fibrosis, which FGF-2, released TGF-β1, involved. α-SMA induction TGF-β1 via both extracellular signal-regulated kinase 1/2 (ERK1/2) Smad3 pathways...
Abstract Asthma is a common allergic disease characterized by airway hypersensitivity and remodeling. Ferroptosis regulated death marked iron accumulation lipid peroxidation. Several environmental pollutants allergens have been shown to cause ferroptosis in epithelial cells, but the relationship between birch pollinosis asthma poorly defined. Here, for first time, we identified of type II alveolar cells mice with Bet v 1-induced asthma. Further analysis revealed that treatment ferrostatin-1...
Adequate sleep is of paramount importance for relieving stress and restoring mental vigor. However, the adverse physiological pathological responses resulting from insufficiency or deprivation (SD) are becoming increasingly prevalent. Currently, impact deficiency on gut microbiota microbiota-associated human diseases, especially cardiac remains controversial. Here, we employed following methods: constructed an experimental sleep-deprivation model in mice; conducted 16S rRNA sequencing to...
Objective: Previous research suggests a potential link between unsaturated fatty acids (UFAs) and ADHD, but the causal relationship remains uncertain. This study aims to investigate association ADHD UFAs using Mendelian randomization (MR) analysis. Methods: Summary data from genome-wide studies were used estimate concentration of circulating UFAs, including Monounsaturated Fatty Acids (MUFAs), Polyunsaturated (PUFAs), Omega-3 PUFAs, Omega-6 Linoleic Acid (LA), Docosahexaenoic (DHA). Data...
Objectives T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) are highly malignant and aggressive hematologic tumors for which there is no standard first-line treatment. Chidamide, a novel histone deacetylase inhibitor, shows great promise. We assessed the efficacy safety of an irradiation-containing conditioning regimen allogeneic hematopoietic stem cell transplantation (allo-HSCT) post-transplantation chidamide maintenance in patients with T-ALL/LBL.
Abstract The fibroblast growth factor (FGF) signaling pathway is a recognized target of cancer therapy. We have developed strong inhibitor (S252W mutant soluble ectodomain FGF recptor-2 IIIc, msFGFR2) that binds FGFs and blocks the activation FGFRs. Thermodynamic binding studies indicated msFGFR2 bound FGF-2 16.9 times as strongly wild-type FGFR2IIIc (wsFGFR2). It successfully suppressed growth, angiogenesis, metastasis two tumor cell lines in vitro vivo, it potently inhibited proliferation...
Nobiletin is a natural product with multiple physiological activities and the main ingredient of Pericarpium Citri Reticulatae. We successfully discovered that nobiletin exhibits aggregation induced emission enhancement (AIEE) properties it has significant advantages such as large Stokes shift, good stability excellent biocompatibility. The increase in methoxy groups endows greater fat-solubility, bioavailability transport rate than corresponding unmethoxylated flavones. Ulteriorly, cells...
Abstract Objective Previous research suggests a potential link between unsaturated fatty acids (UFAs) and attention-deficit/hyperactivity disorder (ADHD), but the causal relationship remains uncertain. This study aims to investigate association ADHD UFAs using Mendelian randomization (MR) analysis. Methods Summary data from genome-wide studies were used estimate levels, including Monounsaturated Fatty Acids (MUFAs), Polyunsaturated (PUFAs), Omega-3 PUFAs, Omega-6 Linoleic Acid (LA),...
Cell-in-cell (CIC) structures have been suggested to mediate intracellular substance transport between cells and found widely in inflammatory lung tissue of asthma. The aim this study was investigate the significance CIC progress related pathways were analyzed asthmatic normal mouse model. In vitro, activation by CIC-mediated intercellular communication RNA-Seq verified Western blotting immunofluorescence. Results showed that lymphocytes alveolar epithelial mediated (such as mitochondria)...
Backgroud Li-Fraumeni syndrome is a hereditary tumor characterized by an elevated risk of malignancy, particularly acute lymphoblastic leukemia (ALL), which can be caused the heterozygous germline mutation. TP53 gene mutation considered potential factor and crucial prognostic parameter for development diagnosis, but rarely occurs in adults, its specific pathogenic significance unclear.
Topic: 2. Acute lymphoblastic leukemia - Clinical Background: T-cell acute leukemia/lymphoma (T-ALL/LBL) is a highly aggressive type of hematological cancer with poor prognosis. Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) currently one the most effective treatment strategies, however, post-transplantation relapse still important factor influencing Here we explore effect Chidamide, novel antineoplastic drug, in maintenance therapy after Allo-HSCT T-ALL/LBL. Aims: To...
Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has cured many patients with malignant hematologic diseases such as mixed phenotype acute leukemia (MPAL), while those relapsing after allo-HSCT still exhibit high mortality, poor prognosis, and no standard treatment modalities. It is necessary to explore more therapeutic modalities for post-transplant relapse obtain a better prognosis. Case presentation In this case report, young male MPAL received reaching complete...