A5101909427- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Proteoglycans and glycosaminoglycans research
- Pharmacological Effects of Natural Compounds
- Functional Brain Connectivity Studies
- Liver physiology and pathology
- Dementia and Cognitive Impairment Research
- Fibroblast Growth Factor Research
- Chromatography in Natural Products
- Brain Tumor Detection and Classification
- Neural dynamics and brain function
- Gas Sensing Nanomaterials and Sensors
- Thyroid Cancer Diagnosis and Treatment
- ZnO doping and properties
- Ginseng Biological Effects and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Radiomics and Machine Learning in Medical Imaging
- Advanced Drug Delivery Systems
- Phytochemistry and biological activity of medicinal plants
- Traffic Prediction and Management Techniques
- AI in cancer detection
- Time Series Analysis and Forecasting
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Non-Destructive Testing Techniques
Ocean University of China
2013-2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Qingdao National Laboratory for Marine Science and Technology
2018-2024
Yangzhou University
2023-2024
Guangzhou Medical University
2020-2024
University of Macau
2023-2024
Sun Yat-sen University
2019-2024
Jiangxi Normal University
2023
Tianjin Medical University General Hospital
2013-2023
The salience network (SN) serves to identify salient stimuli and switch between the central executive (CEN) default-mode (DMN), both of which are impaired in Alzheimer's disease (AD)=amnestic mild cognitive impairment (aMCI).We hypothesized that structural functional organization SN interactions CEN=DMN altered normal aging AD=aMCI.Gray matter volume (GMV) restingstate connectivity (FC) were analyzed from healthy younger (HYC) older controls (HOC) HOC aMCI AD patients.All components showed...
Sulfated polysaccharides from marine algae have high potential as promising candidates for drug development. In this study, a homogeneous sulfated polysaccharide the green alga Monostroma nitidum, designated MS-1, was isolated using water extraction and anion-exchange size-exclusion chromatography. Results of chemical spectroscopic analyses showed that MS-1 mainly consisted →3)-α-l-Rhap-(1→ →2)-α-l-Rhap-(1→ residues, with additional branches consisting 4-linked β-d-xylose, 4-/6-linked...
Great diversity and metabolite complexity of seaweeds offer a unique exclusive source renewable drug molecules. Polysaccharide from seaweed has potential as promising candidate for marine development. In the present study, polysaccharide (SPm) was isolated Monostroma angicava, polymeric repeat units anticoagulant property in vitro vivo SPm were investigated. sulfated which mainly constituted by 3-linked, 2-linked-α-l-rhamnose residues with partially sulfate groups at C-2 3-linked...
Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate structural changes within each RSN between RSNs aMCI/AD patients. Eight were identified from MRI data 35 AD, 18 aMCI 21 normal control subjects using independent component analysis. We compared connectivity (FC) found...
Abstract Working memory is a basic human cognitive function. However, the genetic signatures and their biological pathway remain poorly understood. In present study, we tried to clarify this issue by exploring potential associations pathways among variants, brain morphometry working performance. We first carried out association analyses between 2‐back accuracy 212 image‐derived phenotypes from 1141 Human Connectome Project (HCP) subjects using linear mixed model (LMM). found significantly...
The active sulfated polysaccharide from seaweed possesses important pharmaceutical and biomedical potential. In the study, Monostroma (MSP) was obtained angicava, low-molecular-weight fragments of MSP (MSP-Fs: MSP-F1–MSP-F6) were prepared by controlled acid degradation. molecular weights MSP-F1–MSP-F6 335 kDa, 240 90 40 24 12 6.8 respectively. polysaccharides rhamnans that consisted →3)-α-l-Rhap-(1→ →2)-α-l-Rhap-(1→ units with partial sulfation at C-2 C-3 →2)-α-l-Rhap-(1→. Anticoagulant...
The leaf of the lotus (Nelumbo nucifera) is a kind natural plant resource used as both food and herb medicine (He-Ye) in China. Alkaloids are considered major bioactive compounds exhibit various biological activities, including anti-hyperlipidemia, anti-obesity, anti-inflammatory anti-hyperuricemic effects. Nuciferine (NF) N-nuciferine (N-NF) two alkaloids herb. In present work, plasma brain pharmacokinetics were investigated after oral intravenous (i.v.) administration alkaloid fraction to...
Abstract Background and Objective Clinical studies found high levels of hepatocyte growth factor (HGF) expression in patients with periodontitis. Studies suggest that HGF plays an important role periodontitis, is involved inflammation, modulates alveolar bone integrity This study aims to investigate the effects mechanisms progression experimental Methods We used silk thread ligation induce periodontitis HGF‐overexpressing transgenic (HGF‐Tg) wild‐type C57BL/6J mice. The overexpression on...
The herb of lotus (<italic>Nelumbo nucifera</italic>) leaves is the traditional Chinese medicine He Ye, which commonly used to treat sunstroke, assuage thirst, and cure both diarrhea fever in China.